NCT00408824

Brief Summary

The metabolic syndrome is a highly prevalent disorder, which causes atherosclerotic cardiovascular disease and is closely associated with insulin resistance. The alteration of the secretion of adipocytokines from accumulated visceral adipose tissue in the obese induces insulin resistance. The purpose of this study is to identify gene polymorphisms that confer susceptibility to the metabolic syndrome and to make up a new health guidance program based on genetic risk assessment. About 25% of male employees over 45 years old in a certain company are diagnosed with the metabolic syndrome in medical examination. We, the researchers at Nagoya University, will analyze gene polymorphism and various biomarkers of over 3500 company employees.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
4,000

participants targeted

Target at P75+ for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2006

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

December 6, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

December 7, 2006

Completed
Last Updated

September 20, 2007

Status Verified

September 1, 2007

First QC Date

December 6, 2006

Last Update Submit

September 19, 2007

Conditions

HealthyMetabolic Syndrome XHyperlipidemiaHypertensionDiabetes Mellitus

Keywords

insulin resistanceadipocytokineMetabolic syndromeDiabetes

Eligibility Criteria

Age20 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Healthy subjects who work for a certain company

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Bio-information Analysis, Research Institute of Environmental Medicine, Nagoya University

Nagoya, Aichi-ken, 464-8601, Japan

RECRUITING

Related Publications (1)

  • Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M. Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. Eur J Hum Genet. 2011 Mar;19(3):262-9. doi: 10.1038/ejhg.2010.201. Epub 2010 Dec 8.

    PMID: 21150884DERIVED

MeSH Terms

Conditions

Metabolic SyndromeHyperlipidemiasHypertensionDiabetes MellitusInsulin Resistance

Condition Hierarchy (Ancestors)

HyperinsulinismGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesDyslipidemiasLipid Metabolism DisordersVascular DiseasesCardiovascular DiseasesEndocrine System Diseases

Study Officials

  • Kenji Yasui, MD, PhD

    Department of Bio-information Analysis, Research Institute of Environmental Medicine, Nagoya University

    STUDY CHAIR

Central Study Contacts

Kenji Yasui, MD, PhD

CONTACT

+81-52-788-6211kenji@riem.nagoya-u.ac.jp

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
OTHER
Sponsor Type
OTHER

Study Record Dates

First Submitted

December 6, 2006

First Posted

December 7, 2006

Study Start

September 1, 2006

Last Updated

September 20, 2007

Record last verified: 2007-09

Locations

JP(1)