Investigation of Genetic Risk of Cardiovascular Disease in Prospective Cohort Study

NCT00262691 | Unknown

• 1 other identifier: NU-05-G-0001
• Study Type: observational
• Target: 7,000
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiovascular disease is a complex multifactorial and polygenic disorder that is thought to result from an interaction between a person's genetic make up and various environmental factors. Although many studies have revealed that several genetic variants increase the risk of cardiovascular disease, the results of these studies remain controversial. The purpose of this study is to identify polymorphisms that confer susceptibility to cardiovascular disease and to clarify the adequacy of reported susceptibility gene polymorphisms. To complete this purpose, we will prospectively study over 5,000 local residents in whom relationship between these polymorphisms and occurrence of cardiovascular disease over 5 years.

Conditions

Healthy; Coronary Disease; Myocardial Infarction; Cerebral Infarction

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy subjects who undergo community-based annual health check in Kitanagoya city

Sponsors & Collaborators

• Nagoya University: lead
• Aichi Gakuin University: collaborator

Study Sites (1)

Department of Genome Science, School of Dentistry, Aichi-Gakuin University

Nagoya, Aichi-ken, 464-8651, Japan

RECRUITING

Related Publications (5)

• Ohashi Y, Ichihara S, Yamamoto K, Kitamura Y, Matsubara T, Beppo R, Kinoshita F, Kato TS, Toyoda Y, Kawamura Y, Matsuo H, Ichida K, Yokota M, Nakatochi M. Proteomic footprint of serum urate concentration and urate transporter ABCG2 dysfunctional polymorphism: a cross-sectional study. RMD Open. 2026 Jan 27;12(1):e006414. doi: 10.1136/rmdopen-2025-006414.

  PMID: 41592914 DERIVED

• Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, Matsubara T, Yokota M. Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease. Clin Epigenetics. 2017 May 15;9:54. doi: 10.1186/s13148-017-0353-3. eCollection 2017.

  PMID: 28515798 DERIVED

• Nakatochi M, Miyata S, Tanimura D, Izawa H, Asano H, Murase Y, Kato R, Ichihara S, Naruse K, Matsubara T, Honda H, Yokota M. The ratio of adiponectin to homeostasis model assessment of insulin resistance is a powerful index of each component of metabolic syndrome in an aged Japanese population: results from the KING Study. Diabetes Res Clin Pract. 2011 Jun;92(3):e61-5. doi: 10.1016/j.diabres.2011.02.029. Epub 2011 Mar 31.

  PMID: 21458098 DERIVED

• Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M. Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. Eur J Hum Genet. 2011 Mar;19(3):262-9. doi: 10.1038/ejhg.2010.201. Epub 2010 Dec 8.

  PMID: 21150884 DERIVED

• Asano H, Izawa H, Nagata K, Nakatochi M, Kobayashi M, Hirashiki A, Shintani S, Nishizawa T, Tanimura D, Naruse K, Matsubara T, Murohara T, Yokota M. Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population. Diabetologia. 2010 Feb;53(2):234-46. doi: 10.1007/s00125-009-1517-2. Epub 2009 Sep 1.

  PMID: 19727657 DERIVED

MeSH Terms

Conditions

Coronary Disease; Myocardial Infarction; Cerebral Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Brain Infarction; Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Stroke

Study Officials

• Mitsuhiro Yokota, MD, PhD

  Department of Genome Science, School o Dentistry, Aichi-Gakuin University

  STUDY CHAIR

Central Study Contacts

Mitsuhiro Yokota, MD, PhD

CONTACT

+81-52-759-2111; myokota@dpc.aichi-gakuin.ac.jp

Mitsuhiro Yokota, MD, PhD

CONTACT

+81-52-744-5515; mitsuhiro.yokota@theranos-inst.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 6, 2005
• First Posted: December 7, 2005
• Study Start: May 1, 2005
• Last Updated: September 21, 2007

Record last verified: 2007-09

Locations

JP (1)