Radiation Induced Atherosclerosis in Breast Cancer Patients

NCT00388713 | Unknown

• 1 other identifier: ASBCO5- HMO-CTIL
• Study Type: observational
• Target: 350
• Locations: 1 country
• Sites: 1

Brief Summary

Radiation induced accelerated atherosclerosis is a well known entity that occurs in different regions, according to the therapy delivered.It is usually begins to be clinically evident several years after the radiation incident, as there is sufficient functional reserve to these vessels.Our proposal is aimed to better characterize this side effect. For that purpose, we have chosen to study women who received radiation to the breast, in which part of the carotid in the irradiated side was in the high energy radiation field. We will use Intima Media Thickening ultrasound to study the pattern of atherosclerosis plaque formation in radiated carotid arteries as compared to non-irradiated carotid arteries in women who are receiving radiation therapy for breast cancer.

Conditions

Abnormalities, Radiation-Induced; Atherosclerosis; Breast Cancer

Keywords

Radiation therapy; Radiation-Induced Atherosclerosis; Carotid Artery Diseases; Breast Cancer; Intima Media thickening Ultrasound

Interventions

carotid intima-media thickening ultrasound PROCEDURE

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• women 18-85 Y.O.
• received or about to receive unilateral breast and supraclavicular radiation therapy
• No evidence of disease

You may not qualify if:

• prisoners

Sponsors & Collaborators

• Hadassah Medical Organization: lead

Study Sites (1)

Hadassah Medical Organization

Jerusalem, 91120, Israel

RECRUITING

Related Publications (3)

• Adams MJ, Hardenbergh PH, Constine LS, Lipshultz SE. Radiation-associated cardiovascular disease. Crit Rev Oncol Hematol. 2003 Jan;45(1):55-75. doi: 10.1016/s1040-8428(01)00227-x.

  PMID: 12482572 BACKGROUND

• Cheng SW, Ting AC, Lam LK, Wei WI. Carotid stenosis after radiotherapy for nasopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 2000 Apr;126(4):517-21. doi: 10.1001/archotol.126.4.517.

  PMID: 10772307 BACKGROUND

• Dorresteijn LD, Kappelle AC, Boogerd W, Klokman WJ, Balm AJ, Keus RB, van Leeuwen FE, Bartelink H. Increased risk of ischemic stroke after radiotherapy on the neck in patients younger than 60 years. J Clin Oncol. 2002 Jan 1;20(1):282-8. doi: 10.1200/JCO.2002.20.1.282.

  PMID: 11773180 BACKGROUND

MeSH Terms

Conditions

Abnormalities, Radiation-Induced; Atherosclerosis; Breast Neoplasms; Carotid Artery Diseases

Condition Hierarchy (Ancestors)

Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Radiation Injuries; Wounds and Injuries; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases; Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Amichay Meirovitz, MD

  Hadassah University Hospital, Jerusalem, Israel

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Arik Tzukert, DMD

CONTACT

00 972 2 6776095; arik@hadassah.org.il

Hadas Lemberg, PhD

CONTACT

00 972 2 6777572; lhadas@hadassah.org.il

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: October 15, 2006
• First Posted: October 17, 2006
• Study Start: October 1, 2006
• Study Completion: January 1, 2010
• Last Updated: May 16, 2007

Record last verified: 2005-12

Locations

IL (1)