Psychosocial Impact of Cancer-Related Female Infertility

NCT00386217 | Completed

• 1 other identifier: 2003-0568
• Study Type: observational
• Target: 239
• Locations: 1 country
• Sites: 1

Brief Summary

The success of cancer treatment combined with the trend to delay childbearing is increasing the numbers of women survivors whose childbearing has been interrupted by cancer. For some, treatment has resulted in infertility. Others have been advised to delay pregnancy until a certain follow-up interval or have new fears that pregnancy could be a risk to maternal health. Not least is the concern that children born after a mother's cancer would face increased risks for birth defects or cancer. The specific aims of this project are as follows:

1. 1.To measure the impact of cancer-related interruption of childbearing on women's long-term emotional well-being and health-related quality of life, over and above other demographic and cancer-related factors
2. 2.To find out if becoming a biological or social mother after cancer treatment decreases the long-term psychosocial impact of interrupted childbearing compared to remaining childless
3. 3.To refine the psychometric properties of questionnaires for female cancer survivors measuring Distress about Cancer-Related Childbearing Issues and Attitudes towards Parenthood after Cancer
4. 4.To define targets for a future intervention to improve female survivors' knowledge about childbearing after cancer, decrease distress associated with interrupted childbearing, and promote peer support.

Conditions

Hodgkin's Disease; Cervical Cancer; Breast Cancer; Lymphoma

Keywords

Cervical Cancer; Breast Cancer; Hodgkin's Disease; Non-Hodgkin's Lymphoma; Female Infertility; Telephone Survey

Outcome Measures

Primary Outcomes (1)

• Emotional Impact of Cancer Treatment on Childbearing: Female Cancer Survivor Response to Telephone Survey

  Single telphone survey lasting about 90 minutes, 4 Years to collect complete surveys

Study Arms (1)

Telephone Survey

90 minute Telephone survey of female cancer survivors

Behavioral: Telephone Survey

Interventions

Telephone Survey BEHAVIORAL

Telephone interview, about 90 minutes, covering demographic information, medical information, health-related quality of life, emotional distress, and stress related to interrupted childbearing.

Also known as: Questionnaire

Telephone Survey

Eligibility Criteria

• Age: 14 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Female survivors of breast cancer, cervical cancer, Hodgkin's Disease, or non-Hodgkin's lymphoma, age 14 years and older, who were diagnosed before the age of 41 during the period of 1993-1998.

You may qualify if:

• Women must be survivors of breast cancer, cervical cancer, Hodgkin's Disease, or non-Hodgkin's lymphoma. (We have chosen these three sites because they are the most common malignancies in women of reproductive age that have reasonable rates of long-term survival. In addition, many of the standard treatments for these malignancies impair fertility.)
• Women must have been diagnosed before the age of 41, i.e., of childbearing age at the time of diagnosis and/or beyond.
• Women must be at least age 14 currently to participate, because of the concern that younger girls may not be emotionally mature enough to have considered the emotional aspects of infertility, and may also not have full knowledge about reproduction.
• Women must must have been diagnosed between the years of 1993-1998, making them, roughly 5- to 10-year survivors.
• We are not going to exclude women based on cancer stage or treatment status, as long as they have survived for 5 to 10 years.

You may not qualify if:

• \. Women's fluency in English must be adequate to complete the interview (approximately 6th grade level).

Sponsors & Collaborators

• M.D. Anderson Cancer Center: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

U.T.M.D. Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Related Links

• UT MD Anderson Cancer Center website

MeSH Terms

Conditions

Hodgkin Disease; Uterine Cervical Neoplasms; Breast Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Infertility, Female

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Neoplasms by Histologic Type; Neoplasms; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases; Uterine Neoplasms; Genital Neoplasms, Female; Urogenital Neoplasms; Neoplasms by Site; Uterine Cervical Diseases; Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Infertility

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Leslie R. Schover, PhD

  M.D. Anderson Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 9, 2006
• First Posted: October 11, 2006
• Study Start: December 1, 2004
• Primary Completion: November 1, 2008
• Study Completion: November 1, 2008
• Last Updated: August 1, 2012

Record last verified: 2012-07

Locations

US (1)