Skeletal Muscle Oxygenation in Critically Ill

NCT00384644 | Unknown DMC

• 1 other identifier: NIRS-1
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

It is possible to measure skeletal muscle tissue oxygenation (StO2) using near infrared spectroscopy(NIRS). It is performed non invasively. We want to compare usually used invasive methods for assessing adequacy of flow to StO2 in critically ill. Aim is to faster and non invasively estimate adequacy of flow to make therapeutic algorithms efficient.

Conditions

Heart Failure; Sepsis; Septic Shock; Cardiogenic Shock

Keywords

heart failure; sepsis; septic shock; cardiogenic shock

Study Arms (2)

1

sepsis, septic shock ptients

Device: NiRS measurment of tissue oxygenation

2

cardiogenic shock patients

Device: NiRS measurment of tissue oxygenation

Interventions

NiRS measurment of tissue oxygenation DEVICE

NiRS measurment of tissue oxygenation

1; 2

Eligibility Criteria

• Age: 18 Years - 95 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Intensive care patients

You may qualify if:

• all typs of shock (cardiogenic, septic, hypovolemic, obstractive)

You may not qualify if:

• patients/relatives refuse to participate in study

Sponsors & Collaborators

• University Medical Centre Ljubljana: lead

Study Sites (1)

Clinical Center Ljubljana

Ljubljana, 1000, Slovenia

RECRUITING

Related Publications (3)

• Pareznik R, Knezevic R, Voga G, Podbregar M. Changes in muscle tissue oxygenation during stagnant ischemia in septic patients. Intensive Care Med. 2006 Jan;32(1):87-92. doi: 10.1007/s00134-005-2841-8. Epub 2005 Nov 1.

  PMID: 16261341 BACKGROUND

• Mozina H, Podbregar M. Near-infrared spectroscopy during stagnant ischemia estimates central venous oxygen saturation and mixed venous oxygen saturation discrepancy in patients with severe left heart failure and additional sepsis/septic shock. Crit Care. 2010;14(2):R42. doi: 10.1186/cc8929. Epub 2010 Mar 23.

  PMID: 20331856 DERIVED

• Podbregar M, Mozina H. Skeletal muscle oxygen saturation does not estimate mixed venous oxygen saturation in patients with severe left heart failure and additional severe sepsis or septic shock. Crit Care. 2007;11(1):R6. doi: 10.1186/cc5153.

  PMID: 17227587 DERIVED

MeSH Terms

Conditions

Heart Failure; Sepsis; Shock, Septic; Shock, Cardiogenic

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock; Myocardial Infarction; Myocardial Ischemia; Vascular Diseases; Infarction; Ischemia; Necrosis

Study Officials

• Matej Podbregar, MD PhD

  Medical Faculty, University of Ljubljana

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Matej Podbregar, MD PhD

CONTACT

+386 40 215960; matej.podbegar@guest.arnes.si

Hugon Mozina, MD

CONTACT

+386 41 779078; hugo.mozina@kclj.si

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: October 4, 2006
• First Posted: October 6, 2006
• Study Start: April 1, 2004
• Primary Completion: January 1, 2009
• Study Completion: December 1, 2010
• Last Updated: June 5, 2008

Record last verified: 2008-06

Locations

SL (1)