Blood Collection From Individuals With Lung Disease for Genetic Studies

NCT00362739 | Completed DMC

• 1 other identifier: 0508008095
• Study Type: observational
• Target: 3,087
• Locations: 1 country
• Sites: 1

Brief Summary

This is a research study where researchers are collecting blood to evaluate the genetic characteristics of individuals with chronic lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, cystic fibrosis, and lung cancer.

Conditions

Asthma; COPD; Interstitial Lung Disease; Cystic Fibrosis; Lung Cancer

Outcome Measures

Primary Outcomes (1)

• Establish a set of normal ranges for various parameters in healthy individual specimens and compare to specimens from individuals with lung disease to determine parameters resulting in disease susceptibility and severity.

  5 years

Study Arms (2)

1: Lung Disease

Individuals with at least one of the following: (1)symptoms consistent with pulmonary disease; (2) chest X-ray consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; (6) patients with diseases of organs with known association with lung disease; (7) individuals suspected of history of lung diseased based on history and/or physical examination

2: Normal Controls

Individuals without a history of lung disease

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals visiting the Starr-5 Pulmonary, Critical Care Unit, and 5 West floor for standard clinical care will be recruited. Controls will be obtained from volunteers without a history of lung disease.

You may qualify if:

• Must provide informed consent
• Males and females, age 18 years and older
• Lung disease proven by at least one of the following:
• symptoms consistent with pulmonary disease
• chest X-rays consistent with lung disease
• pulmonary function tests consistent with lung disease
• lung biopsy consistent with lung disease
• family history of lung disease
• disease of organs with know associated with lung disease
• individuals suspected of history of lung disease based on history and/or physical examination
• normal controls (individuals without history of lung disease) to be sampled to provide a comparison to the lung disease cohort.

You may not qualify if:

• Drug and/or alcohol abuse within the past six months
• Females who are pregnant or nursing

Sponsors & Collaborators

• Weill Medical College of Cornell University: lead

Study Sites (1)

New York Presbyterian Hospital -- Weill Cornell Medical College of Cornell University

New York, New York, 10021, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

In this study, a small amount of blood for extraction of DNA for the study of the genetic basis of lung disease will be obtained from each subject. The collected blood (cells and serum) will be used for genetic testing in studies relating to the genetic material and/or gene expression, and/or studies of proteins or other substances in serum (the liquid portion of the blood after it has been allowed to clot). Because these latter protein studies will occur at a future date, the serum will be stored for use in these studies.

MeSH Terms

Conditions

Asthma; Pulmonary Disease, Chronic Obstructive; Lung Diseases, Interstitial; Cystic Fibrosis; Lung Neoplasms

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pancreatic Diseases; Digestive System Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infant, Newborn, Diseases; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms

Study Officials

• Ronald G Crystal, MD

  The New York Presbyterian Hospital -- Weill Medical College of Cornell University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 8, 2006
• First Posted: August 10, 2006
• Study Start: September 1, 2005
• Primary Completion: August 1, 2015
• Study Completion: August 1, 2015
• Last Updated: April 29, 2016

Record last verified: 2016-04

Locations

US (1)