Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases

NCT00357071 | Completed

• 2 other identifiers: 03012203-EI-0122
• Study Type: observational
• Target: 219
• Locations: 1 country
• Sites: 1

Brief Summary

This study will collect blood samples from patients with non-infectious eye inflammatory diseases a spectrum of eye disorders that can produce sight-threatening vision loss. The blood will be analyzed for substances that may provide a better understanding of the nature of these disorders, possibly leading to improved treatments. Treatment is not offered under this protocol. Patients 6 years of age and older with an eye inflammatory disease, including non-infectious uveitis, ocular cicatricial pemphigoid, non-infectious scleritis, episcleritis, Stevens Johnson syndrome, Moorens ulcer, peripheral ulcerative keratitis and keratoconjunctivitis sicca, may be eligible for this study. Patients may or may not currently be participating in a treatment trial. Participants will have blood drawn through a needle in an arm vein. More samples may be collected if patients enrolled in another study are scheduled for additional visits. No more than 4 teaspoonfuls of blood will be collected at any one time.

Conditions

Eye Diseases

Keywords

Autoimmunity; Cell Mediated Immunity; S Antigen; Cell Proliferation; Uveitis; Cell Proliferation Assays; Auto-Antibody; Auto-Antigens

Eligibility Criteria

• Age: 6 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Participant is 6 years or older.
• Adult participant is able to understand and sign the informed consent. If the participant is younger than 18 years of age at enrollment, has a parent or legal guardian who is able to understand and sign the consent on their behalf. Children must provide assent.
• Patients must have a diagnosis of an ocular inflammatory disease, AMD or diabetic retinopathy.

You may not qualify if:

• The presence of non-ocular inflammatory disease.
• Unwilling or unable to provide a blood sample.

Sponsors & Collaborators

• National Eye Institute (NEI): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Foster CS, Kenyon KR, Greiner J, Greineder DK, Friedland B, Allansmith MR. The immunopathology of Mooren's ulcer. Am J Ophthalmol. 1979 Aug;88(2):149-59. doi: 10.1016/0002-9394(79)90459-8.

  PMID: 382859 BACKGROUND

• Kriukova ME, Bocharova-Messner OM, Stefanov SB. [Shape factor of myofibril cross sections of functionally different muscles of the cricket Acheta domestica]. Zh Evol Biokhim Fiziol. 1978 Nov-Dec;14(6):571-5. No abstract available. Russian.

  PMID: 735597 BACKGROUND

• Murray PI, Rahi AH. Pathogenesis of Mooren's ulcer: some new concepts. Br J Ophthalmol. 1984 Mar;68(3):182-7. doi: 10.1136/bjo.68.3.182.

  PMID: 6230102 BACKGROUND

MeSH Terms

Conditions

Eye Diseases; Autoimmune Diseases; Hyperplasia; Uveitis

Condition Hierarchy (Ancestors)

Immune System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Uveal Diseases

Study Officials

• Hatice N Sen, M.D.

  National Eye Institute (NEI)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 26, 2006
• First Posted: July 27, 2006
• Study Start: April 7, 2003
• Study Completion: July 24, 2018
• Last Updated: July 26, 2018

Record last verified: 2018-07-24

Locations

US (1)