NCT00353925|Completed
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Sponsor study identifier
Secondary identifiers
observational
1,000
1 country
1
Study Start
October 5, 1999
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
December 10, 2007
Date type not reportedThis date has not been verified as actual or estimated.
The purpose of this study is to learn if kinase, a protein found in the heart, contributes to thickening of the heart muscle in people with high blood pressure. A protein called myosin causes the heart to contract and relax. It is thought that kinase changes myosin to make it work better at different heart rates. This study will try to determine if, in some people with high blood pressure, the different forms of this protein cause changes in the heart. If the protein affects the size of the heart, it might be possible to use it to improve heart function after an injury, such as a heart attack. African-Americans with high blood pressure will be eligible for this study. Current data show that of almost 900 multi-ethnic individuals, the particular form of kinase under study in this project is found exclusively in the African-American population. Study participants will have two tubes of blood drawn for DNA testing to determine what form of kinase is present. An electrocardiogram will also be done if a recent one is not available. Some people may also have an echocardiogram, an ultrasound test to image the heart.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 10, 2007
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 5, 1999
Date type not reportedThis date has not been verified as actual or estimated.
July 18, 2006
Actual (reported)July 19, 2006
Actual (reported)December 10, 2007
Date type not reportedThis date has not been verified as actual or estimated.
University of Maryland, Baltimore
Baltimore, Maryland, 21201-1595, United States
Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978 Dec;58(6):1072-83. doi: 10.1161/01.cir.58.6.1072.
First Submitted
July 18, 2006
First Posted
July 19, 2006
Study Start
October 5, 1999
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
December 10, 2007
Date type not reportedThis date has not been verified as actual or estimated.
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)
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Last Updated
July 2, 2017
Record last verified: 2007-12-10
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Source: ClinicalTrials.gov.
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