Genetic Analysis of African-Americans With High Blood Pressure

NCT00353925 | Completed

• 2 other identifiers: 00000300-H-0003
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to learn if kinase, a protein found in the heart, contributes to thickening of the heart muscle in people with high blood pressure. A protein called myosin causes the heart to contract and relax. It is thought that kinase changes myosin to make it work better at different heart rates. This study will try to determine if, in some people with high blood pressure, the different forms of this protein cause changes in the heart. If the protein affects the size of the heart, it might be possible to use it to improve heart function after an injury, such as a heart attack. African-Americans with high blood pressure will be eligible for this study. Current data show that of almost 900 multi-ethnic individuals, the particular form of kinase under study in this project is found exclusively in the African-American population. Study participants will have two tubes of blood drawn for DNA testing to determine what form of kinase is present. An electrocardiogram will also be done if a recent one is not available. Some people may also have an echocardiogram, an ultrasound test to image the heart.

Conditions

Hypertension

Keywords

Hypertrophy; LVH; Cardiac; Blood Pressure; Papillary Muscle

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Afro-American patients with a history of hypertension
• Age greater than or equal to 21 years old
• Presence of the kinase allele (homo or heterozygous)
• Ability to give informed consent.
• All of the above as well as:
• Left ventricular ejection fraction of less than 35% by any imaging technique.

You may not qualify if:

• For subjects with Kinase Allele:
• For Subjects without the kinase allele and Myopathy Cohort:
• History of myocardial infarction
• History of significant valve disease
• History of primary hyperthropic or infiltrative cardiomyopathy
• History of rheumatic heart disease
• Chronic atrial arrhythmia, bundle branch block intraventricular conduction defect or definite myocardial infarction on EKG
• Inability to perform a metabolic stress test
• Inability to perform a cMRI
• Poor echocardiographic windows precluding accurate analysis

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Study Sites (1)

University of Maryland, Baltimore

Baltimore, Maryland, 21201-1595, United States

Location

Related Publications (1)

• Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978 Dec;58(6):1072-83. doi: 10.1161/01.cir.58.6.1072.

  PMID: 709763 BACKGROUND

MeSH Terms

Conditions

Hypertension; Hypertrophy

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: July 18, 2006
• First Posted: July 19, 2006
• Study Start: October 5, 1999
• Study Completion: December 10, 2007
• Last Updated: July 2, 2017

Record last verified: 2007-12-10

Locations

US (1)