Coronary Atherosclerosis Evaluation by Arterial Wall Magnetic Resonance Imaging (MRI)
2 other identifiers
interventional
179
1 country
2
Brief Summary
The overall goal of this study is to use MRI to:
- Examine the relationship between known risk factors for cardiovascular disease and coronary artery wall thickness;
- Examine the relationship between coronary artery wall thickness and other markers of subclinical coronary atherosclerosis, such as carotid wall thickness and coronary calcium scores; and,
- Examine the feasibility of measuring the progression of coronary artery wall thickness over time in a subset of participants.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jul 2005
Typical duration for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2005
CompletedFirst Submitted
Initial submission to the registry
July 18, 2006
CompletedFirst Posted
Study publicly available on registry
July 19, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2008
CompletedResults Posted
Study results publicly available
June 22, 2010
CompletedJune 22, 2010
September 1, 2009
2.9 years
July 18, 2006
August 4, 2009
May 25, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Mean Coronary Wall Thickness
Average thickness of the wall of the left anterior descending, right and left main coronary artery measured by magnetic resonance imaging (MRI).
n/a (cross sectional analysis)
Interventions
Eligibility Criteria
You may qualify if:
- Prior enrollment in the MESA Study at the Hopkins MESA Field Center or the Northwestern University MESA Field Center
- Male or Female adult equal to or older than 45 years of age
- Willing/able to provide informed consent
You may not qualify if:
- Any known contraindications to MRI (i.e. severe claustrophobia, pacemaker, etc.)
- Metal in the eyes
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Johns Hopkins Universitylead
- Northwestern Universitycollaborator
Study Sites (2)
Northwestern University MESA Field Center
Chicago, Illinois, 60611, United States
Johns Hopkins MESA Field Center
Baltimore, Maryland, 21244, United States
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Limitations and Caveats
Cross sectional study
Results Point of Contact
- Title
- David Bluemke
- Organization
- NIH
Study Officials
- PRINCIPAL INVESTIGATOR
David A Bluemke, MD PhD
Johns Hopkins University
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
July 18, 2006
First Posted
July 19, 2006
Study Start
July 1, 2005
Primary Completion
June 1, 2008
Study Completion
June 1, 2008
Last Updated
June 22, 2010
Results First Posted
June 22, 2010
Record last verified: 2009-09