Analysis of the Immune Response to the Malaria Parasite in Mali, West Africa

NCT00346346 | Completed

• 2 other identifiers: 99990614706-I-N147
• Study Type: observational
• Target: 237
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine the immune response to the malaria parasite at the cellular level to better understand why people achieve natural immunity to the parasite only after multiple infections and why immunity diminishes rapidly in the absence of ongoing infection. The results of this study may provide insight into whether and how natural immunity can be improved upon by vaccination. Healthy people 2-4 and 18-25 years of age who live in the village of Kambila, Mali, may be eligible for this 1-year study. Participants have a small blood sample collected from a vein in the arm and also from two finger pricks at the beginning of the study, then every 2 months for 6 months and at the end of the study (for a total of five samples). People who become ill with malaria are evaluated and treated by a physician. Those recovering from their first episode of malaria during the study period have another blood sample collection and two finger pricks (bringing to six the total number of samples collected).

Conditions

Malaria

Keywords

Immunity; Memory; ELISPOT; Malaria; Prospective

Eligibility Criteria

• Age: 2 Years - 25 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Males and females ages 2 to 10 years or 18 to 25 years.
• Will be living in Kambila for one year and available for 12 month follow-up.
• Willing to have blood specimens stored.
• Willingness of adult volunteer to participate in the study as evidenced by the completed informed consent document.
• Willingness of parent or guardian to have his or her child participate in the study as evidenced by the completed informed consent document.

You may not qualify if:

• Active bleeding or hematocrit less than or equal to 15 % (for both children and adults).
• Fever greater than 38 degrees C, or systemic illness at enrollment.
• Currently using anti-malarial medications.
• Current pregnancy or a plan to become pregnant during the one year study period. Pregnancy status will be determined at enrollment by urine dipstick, and at subsequent time points by self-report only.
• While on this protocol, if a subject enrolls in another study that requires the administration of experimental therapies (vaccines or medications), he/she may no longer participate in this protocol.

Sponsors & Collaborators

• National Institute of Allergy and Infectious Diseases (NIAID): lead

Study Sites (1)

Malaria Research and Training Center

Bamako, Mali

Location

Related Publications (3)

• Achidi EA, Perlmann H, Salimonu LS, Perlmann P, Walker O, Asuzu MC. A longitudinal study of seroreactivities to Plasmodium falciparum antigens in Nigerian infants during their first year of life. Acta Trop. 1995 May;59(2):173-83. doi: 10.1016/0001-706x(95)00076-q.

  PMID: 7676908 BACKGROUND

• ALLISON AC. Protection afforded by sickle-cell trait against subtertian malareal infection. Br Med J. 1954 Feb 6;1(4857):290-4. doi: 10.1136/bmj.1.4857.290. No abstract available.

  PMID: 13115700 BACKGROUND

• ALLISON AC. Glucose-6-phosphate dehydrogenase deficiency in red blood cells of East Africans. Nature. 1960 May 14;186:531-2. doi: 10.1038/186531a0. No abstract available.

  PMID: 13792821 BACKGROUND

MeSH Terms

Conditions

Malaria

Condition Hierarchy (Ancestors)

Protozoan Infections; Parasitic Diseases; Infections; Mosquito-Borne Diseases; Vector Borne Diseases

Study Officials

• Peter D Crompton, M.D.

  National Institute of Allergy and Infectious Diseases (NIAID)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: June 28, 2006
• First Posted: June 29, 2006
• Study Start: April 17, 2006
• Study Completion: January 23, 2013
• Last Updated: December 5, 2019

Record last verified: 2013-01-23

Locations

MA (1)