An fMRI Study of Self-regulation in Adolescents With Bulimia Nervosa

NCT00345943 | Completed Results DMC

• 3 other identifiers: #5606R/6679RR01MH090062DDTR M2-MBB
• Study Type: observational
• Target: 71
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this project is to use both multimodal MRI and behavioral measures to investigate how changes in frontostriatal neural systems contribute to the development and persistence of Bulimia Nervosa (BN). Findings from this study will have wide-ranging importance for our understanding of the development and treatment of BN.

Conditions

Eating Disorders

Keywords

Eating Disorders; Bulimia Nervosa; Bulimia; fMRI; Magnetic Resonance Imaging

Outcome Measures

Primary Outcomes (1)

• Magnetic Resonance Imaging Scans

  This study will use magnetic resonance imaging (MRI) to assess the structure (cortical thickness) of neural circuit regions involved in Bulimia Nervosa (BN).

  Baseline

Secondary Outcomes (3)

• Conners Continuous Performance Test-II (CPT-II)

  Baseline

• Stroop Word-Color Interference

  Baseline

• Weather Prediction Task

  Baseline

Study Arms (2)

Adolescents with Bulimia Nervosa or subclinical BN

Adolescents with Bulimia Nervosa or subclinical Bulimia Nervosa

Other: MRI; Behavioral: Neuropsychological Testing

Healthy control adolescents

Healthy control adolescents

Other: MRI; Behavioral: Neuropsychological Testing

Interventions

MRI OTHER

Magnetic Resonance Imaging scans

Also known as: GE 3T scanner, Anatomical Images, DTI, and MRS

Adolescents with Bulimia Nervosa or subclinical BN; Healthy control adolescents

Neuropsychological Testing BEHAVIORAL

Neuropsychological tests

Also known as: Wechsler Abbreviated Scale of Intelligence (WASI), Continuous Performance Task, Stroop Word-Color Interference, Weather Prediction Task

Adolescents with Bulimia Nervosa or subclinical BN; Healthy control adolescents

Eligibility Criteria

• Age: 12 Years - 17 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Adolescents (ages 12-17 years) with bulimia nervosa and age, gender, and weight-matched controls

You may qualify if:

• Current or prior DSM IV diagnosis of Bulimia Nervosa or Sub-threshold Bulimia Nervosa (those who meet all DSM-IV criteria for BN, but engage in subjective binge-eating episodes and binge/purge at a frequency of at least once per week for 3 months, whereas meeting full DSM-IV criteria for BN requires binge eating and purging twice per week for 3 months)
• Major Depression
• For control adolescents, no current or past history of an eating disorder

You may not qualify if:

• Ferromagnetic implants (e.g., pacemaker)
• Metal braces or retainers
• IQ less than 80
• Any other current major Axis I disorder, other than major depressive disorder (MDD)
• History of concussion, seizure disorder, or other neurological illness
• Claustrophobia
• Pregnant

Sponsors & Collaborators

• New York State Psychiatric Institute: lead
• National Institute of Mental Health (NIMH): collaborator

Study Sites (1)

New York State Psychiatric Institute at Columbia University Medical Center

New York, New York, 10032, United States

Location

Related Publications (3)

• Berner LA, Wang Z, Stefan M, Lee S, Huo Z, Cyr M, Marsh R. Subcortical Shape Abnormalities in Bulimia Nervosa. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Dec;4(12):1070-1079. doi: 10.1016/j.bpsc.2018.12.011. Epub 2019 Jan 4.

  PMID: 30846367 DERIVED

• Cyr M, Wang Z, Tau GZ, Zhao G, Friedl E, Stefan M, Terranova K, Marsh R. Reward-Based Spatial Learning in Teens With Bulimia Nervosa. J Am Acad Child Adolesc Psychiatry. 2016 Nov;55(11):962-971.e3. doi: 10.1016/j.jaac.2016.07.778. Epub 2016 Sep 8.

  PMID: 27806864 DERIVED

• Marsh R, Maia TV, Peterson BS. Functional disturbances within frontostriatal circuits across multiple childhood psychopathologies. Am J Psychiatry. 2009 Jun;166(6):664-74. doi: 10.1176/appi.ajp.2009.08091354. Epub 2009 May 15.

  PMID: 19448188 DERIVED

MeSH Terms

Conditions

Feeding and Eating Disorders; Bulimia Nervosa; Bulimia

Interventions

Diffusion Tensor Imaging; Neuropsychological Tests

Condition Hierarchy (Ancestors)

Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders; Hyperphagia

Intervention Hierarchy (Ancestors)

Neuroimaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Diffusion Magnetic Resonance Imaging; Magnetic Resonance Imaging; Tomography; Diagnostic Techniques, Neurological; Investigative Techniques; Psychological Tests; Behavioral Disciplines and Activities

Results Point of Contact

• Title: Dr. Rachel Marsh
• Organization: New York State Psychiatric Institute

rachel.marsh@nyspi.columbia.edu

6467745774

Study Officials

• Rachel Marsh, PhD

  Columbia University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Scientist

Study Record Dates

• First Submitted: June 28, 2006
• First Posted: June 29, 2006
• Study Start: October 1, 2004
• Primary Completion: September 1, 2016
• Study Completion: August 1, 2021
• Last Updated: December 2, 2021
• Results First Posted: December 2, 2021

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will share

Locations

US (1)