Invasive Prenatal Testing Decisions in Pregnancy After Infertility

NCT00341822 | Completed

• 2 other identifiers: 99990613206-HG-N132
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This study will explore the decision-making experiences of women who are currently pregnant following a period of infertility on whether or not to undergo an invasive prenatal test (IPT) procedure, such as amniocentesis or chorionic villus sampling. Women who become pregnant after infertility often experience heightened anxiety regarding the outcome of the pregnancy. When choosing whether or not to have IPT they are faced with a complex decision, set in the unique context of a pregnancy that they often perceive as exceptionally precarious. Women who are pregnant with their first child after a period of infertility and have made a decision regarding whether or not to undergo IPT may be eligible for this study. Participants complete an online password-protected questionnaire that measures infertility and decision-making variables and explores women's perceptions of the impact of infertility on their IPT decision-making process. The questionnaire covers the following areas:

• Subject's demographic information, such as age, marital status, number of children, education, race, ethnicity
• Subject's infertility history
• Subject's thoughts and feelings about infertility
• Subject's thoughts and concerns about other people's (e.g., husband, doctor, other infertile women) opinions about IPT
• Subject's decision about whether or not to have IPT and her feelings regarding the decision
• The effect of subject's infertility history on her decision to have or not have IPT

Conditions

Pregnancy

Keywords

Amniocentesis; Chorionic Villus Sampling; Fertility; Genetic Counseling; Decisional Conflict; Prenatal Testing; Questionnaire

Eligibility Criteria

• Age: 35 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Women.
• Self-reported history of infertility.
• Currently pregnant.
• First pregnancy after period of infertility.
• Have been offered IPT during current pregnancy for risk of aneuploidy due to maternal age greater than 35 years, abnormal first or second trimester screening or an ultrasound anomaly.
• Have made decision about IPT.
• Ability to read and write English.

You may not qualify if:

• Men, children.

Sponsors & Collaborators

• National Human Genome Research Institute (NHGRI): lead

Study Sites (1)

Johns Hopkins University

Baltimore, Maryland, 21205, United States

Location

Related Publications (1)

• Reading AE, Chang LC, Kerin JF. Attitudes and anxiety levels in women conceiving through in vitro fertilization and gamete intrafallopian transfer. Fertil Steril. 1989 Jul;52(1):95-9. doi: 10.1016/s0015-0282(16)60796-3.

  PMID: 2663553 BACKGROUND

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: June 19, 2006
• First Posted: June 21, 2006
• Study Start: March 29, 2006
• Study Completion: December 28, 2007
• Last Updated: July 2, 2017

Record last verified: 2007-12-28

Locations

US (1)