NCT00340834

Brief Summary

This study assessed the safety, tolerability, and efficacy of 2 doses of oral fingolimod versus interferon β-1a to reduce the frequency of relapses in patients with relapsing-remitting multiple sclerosis.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
1,292

participants targeted

Target at P75+ for phase_3 multiple-sclerosis

Timeline
Completed

Started May 2006

Typical duration for phase_3 multiple-sclerosis

Geographic Reach
17 countries

163 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2006

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

June 19, 2006

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 21, 2006

Completed
4.9 years until next milestone

Results Posted

Study results publicly available

May 16, 2011

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2011

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2011

Completed
Last Updated

September 21, 2017

Status Verified

August 1, 2017

Enrollment Period

5.2 years

First QC Date

June 19, 2006

Results QC Date

January 4, 2011

Last Update Submit

August 18, 2017

Conditions

Keywords

FTY720InterferonRRMSMultiple SclerosisEfficacy

Outcome Measures

Primary Outcomes (1)

  • Estimated Annualized Aggregate Relapse Rate (ARR) in the Core Phase of the Study

    The ARR is defined as the number of confirmed relapses in a year. A relapse is defined as the appearance of a new or worsening of a previously stable or improving pre existing neurological abnormality, separated by at least 30 days from onset of a preceding relapse. The abnormality must be present for at least 24 hours and occur in the absence of fever or infection. The annualized ARR for each treatment group was calculated using negative binomial regression adjusted by treatment, country, number of relapses in the previous 2 years, and the baseline Expanded Disability Status Scale score.

    Baseline to Month 12

Secondary Outcomes (5)

  • Number of New or Newly Enlarged T2 Lesions in Comparison With Baseline in the Core Phase of the Study

    Baseline to Month 12

  • Percentage of Participants Free of 3-month Disability Progression Assessed With the Expanded Disability Status Scale (EDSS) at the End of the Core Phase of the Study

    Baseline to Month 12

  • Estimated Annualized Aggregate Relapse Rate (ARR) in the Core and Extension Phases of the Study

    Month 0 to end of study (up to approximately 4.5 years)

  • Number of New or Newly Enlarged T2 Lesions in the Extension Phase of the Study

    Month 12 to end of study (up to approximately 3.5 years)

  • Percentage of Participants Free of 3-month and 6-month Disability Progression Assessed With the Expanded Disability Status Scale (EDSS) at the End of the Extension Phase of the Study

    Baseline to end of study (up to approximately 4.5 years)

Study Arms (3)

Fingolimod 1.25 mg

EXPERIMENTAL
Drug: Fingolimod 1.25 mg

Fingolimod 0.5 mg

EXPERIMENTAL
Drug: Fingolimod 0.5 mg

Interferon β-1a 30 µg

ACTIVE COMPARATOR
Drug: Interferon β-1a 30 µg

Interventions

Core: Patients self-administered fingolimod 1.25 mg capsules orally once daily. In addition, they self-administered an interferon β-1a placebo intramuscular (im) injection once weekly. Extension: Patients self-administered fingolimod 1.25 mg capsules orally once daily until switched to 0.5 mg capsules upon study protocol amendment.

Also known as: FTY720
Fingolimod 1.25 mg

Core: Patients self-administered fingolimod 0.5 mg capsules orally once daily. In addition, they self-administered an interferon β-1a placebo intramuscular (im) injection once weekly. Extension: Patients self-administered fingolimod 0.5 mg capsules orally once daily.

Also known as: FTY720
Fingolimod 0.5 mg

Core: Patients self-administered interferon β-1a 30 μg in an intramuscular (im) injection once weekly. In addition, they self-administered a fingolimod placebo capsule orally once daily. Extension: Patients self-administered either fingolimod 1.25 mg or 0.5 mg capsules orally once daily until switched to 0.5 mg capsules upon study protocol amendment.

Interferon β-1a 30 µg

Eligibility Criteria

Age18 Years - 55 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Male and female patients between ages 18-55 with a diagnosis of multiple sclerosis (MS)
  • Patients with a relapsing-remitting disease course
  • Patients with Expanded Disability Status Scale (EDSS) score of 0-5.5

You may not qualify if:

  • Patients with other chronic disease of the immune system, malignancies, acute pulmonary disease, cardiac failure, etc
  • Pregnant or nursing women
  • Patients who cannot tolerate treatment with an interferon

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (170)

North Central Neurology Associates, PC, 1809 Kress Street

Cullman, Alabama, 35058, United States

Location

Barrow Neurological Institute

Phoenix, Arizona, 85013, United States

Location

The Neurology Center, 3907 Waring Road, Suite 3

Oceanside, California, 92056, United States

Location

Associated Neurologists, PC, 69 Sand Pit Road, Suite 300

Danbury, Connecticut, 06810, United States

Location

Associated Neurologists of Southern CT, PC, 75 Kings Highway Cutoff

Fairfield, Connecticut, 06824, United States

Location

Yale University Multiple Sclerosis Center

New Haven, Connecticut, 06510, United States

Location

University of Florida Health Science Center

Jacksonville, Florida, 32209, United States

Location

Neurology Associates, PA, 301 N. Maitland Avenue, Suite A1

Maitland, Florida, 32751, United States

Location

University of Miami, Department of Neurology

Miami, Florida, 33136, United States

Location

Neurological Associates

Pompano Beach, Florida, 33060, United States

Location

Roskamp Institute, 2040 Whitfield Ave.

Sarasota, Florida, 34243, United States

Location

AMO Corporation

Tallahassee, Florida, 32308, United States

Location

Axiom Clinical Research of Florida, 2919 Swann Avenue, Suite 401

Tampa, Florida, 33609, United States

Location

University of South Florida, Department of Neurology

Tampa, Florida, 33612, United States

Location

The MS Center of Vero Beach

Vero Beach, Florida, 32960, United States

Location

University of Kansas Medical Center

Kansas City, Kansas, 66160, United States

Location

Mid America Neuroscience Institute, 8550 Marshall Drive, Suite 100

Lenexa, Kansas, 66214, United States

Location

University Physician Group, #1 Barnes-Jewish Hospital Plaza, Suite 16304

St Louis, Missouri, 63110, United States

Location

Neuroscience and Spine Center

Charlotte, North Carolina, 28207, United States

Location

Raleigh Neurology Associates, 1540 Sunday Drive

Raleigh, North Carolina, 27607, United States

Location

Neurology & Neuroscience Associates, Inc

Akron, Ohio, 44302, United States

Location

Northern Ohio Neuroscience, LLC

Bellevue, Ohio, 44811, United States

Location

Cleveland Clinic

Cleveland, Ohio, 44195, United States

Location

Oregon Neurology

Tualatin, Oregon, 97062, United States

Location

University of Pittsburgh, Department of Neurology

Pittsburgh, Pennsylvania, 15213, United States

Location

Absher Neurology, 274-A Commonwealth Drive

Greenville, South Carolina, 29615, United States

Location

Mountain Empire Neurological Associates, PC, 3183 West State Street, Suite 1201

Bristol, Tennessee, 37620, United States

Location

Advanced Neurosciences Institute

Franklin, Tennessee, 37064, United States

Location

Baylor College of Medicine

Houston, Texas, 77030, United States

Location

Private Practice, 3815 23rd Street

Lubbock, Texas, 79410, United States

Location

Integra Clinical Research, 4242 Medical Drive, Suite 6100

San Antonio, Texas, 78229, United States

Location

Swedish Neuroscience Institute

Seattle, Washington, 98122, United States

Location

Rockwood Clinic, P.S.

Spokane, Washington, 99202, United States

Location

West Virginia University Health Associates

Morgantown, West Virginia, 26506, United States

Location

Center for Neurological Disorders - Aurora St. Luke's Med Center

Milwaukee, Wisconsin, 53215, United States

Location

Ineba

Guarda Vieja 4435, Capital Federal, Buenos Aires, 1428, Argentina

Location

Fundacion Rosarina de Neurorehabilitacion

Rosario, Santa Fe Province, 2000, Argentina

Location

Instituto de Neurociencias de Rosario

Rosario, Santa Fe Province, 2000, Argentina

Location

Hospital Italiano de Buenos Aires

Buenos Aires, C118ACK, Argentina

Location

Fundacion Lenox Cordoba

Córdoba, 5000, Argentina

Location

Hospital J. M. Ramos Mejia

General Urquiza 609, Buenos Aires, C1221ADC, Argentina

Location

FLENI

Montaneses 2325, Buenos Aires, C1428AQK, Argentina

Location

Strategic Health Evaluators

Chatswood, New South Wales, 2067, Australia

Location

Royal Prince Alfred Hospital

Department of Medicine, Level, Missenden R, Camperdown, New South Wales, 2050, Australia

Location

Liverpool Hospital, Neurology Department, Health Services Building, 4th Floor, Goulburn and Campbell Street

Liverpool, New South Wales, 2170, Australia

Location

Gosford Private Hospital

North Gosford, New South Wales, 2250, Australia

Location

St George Private Hospital

Suite 7E, Level 5, South Street, Kogarah, New South Wales, 2217, Australia

Location

Box Hill Hopsital, Level 3, 16 Arnold Street

Box Hill, Victoria, 3128, Australia

Location

Royal Melbourne Hospital

Suite 30, Grattan St., Parkbville, Victoria, 3050, Australia

Location

Landesklinikum St. Poelten, Probst-Ruehrer-Str. 4

Sankt Pölten, Sankt Poelten, 3100, Austria

Location

Landes-Narvenklinik Wagner-Jauregg

Abteilung Fuer Neurologie, Linz, A-4020, Austria

Location

Universitätsklinik f. Neurologie Innsbruck

Anichstrasse 35, Innsbruck, 6020, Austria

Location

Landes-Nervenklinik Christian Doppler Klinik

Ignaz Harrerstr. 79 , Salzburg, A-5020, Austria

Location

Evangel.Krankenh./Wien-Waehring Außenstelle

Vienna, 1010, Austria

Location

Univ.-Klinik fuer Neurologie AKH

Vienna, 1090, Austria

Location

Cliniques Universitaires Saint Luc

Avenue Hippocrate 10, Bruxelles, 1200, Belgium

Location

UZ Brussel

Laarbeeklaan 101, Brussels, 1090, Belgium

Location

Nationaal Multiple Sclerose Centrum v.z.w

Melsbroek, 1820, Belgium

Location

Regionaal Ziekenhuis Sint-Trudo - Campus Sint-Jozef

Sint-Truiden, 3800, Belgium

Location

Hospital Sao Rafael

Salvador, Estado de Bahia, 41256 900, Brazil

Location

Hospital das Clincas - UNICAMP

Campinas, São Paulo, 13083-970, Brazil

Location

Hospital das Clinicas da FMRPUSP

Ribeirão Preto, São Paulo, 48000-900, Brazil

Location

Irmandade da Santa Casa de Misericordia de Porto Alegre

Porto Alegre, RS 90020-090, Brazil

Location

Hospital dos Servidores do Estado

Rio de Janeiro, RJ 20221-903, Brazil

Location

Hospital Universitario Gaffree e Guinle

Rio de Janeiro, RJ 20270-004, Brazil

Location

Fraser Health MS Clinic, Burnaby Hospital, 3935 Kincaid Street

Vancouver, British Columbia, V56 2X6, Canada

Location

UBC MS Research, 2211 Westbrook Mall

Vancouver, British Columbia, V6T 2B5, Canada

Location

Nepean Medical Centre, 1 Centrepointe Drive, Suite 407

Ottawa, Ontario, K2G 6E2, Canada

Location

St. Michael's Hospital, Chief, Division of Neurology, 30 Bond Street,Suite 3007 - Shuter Wing

Toronto, Ontario, M5B 1W8, Canada

Location

Centre Hospitalier Universitaire de Sherbrooke, 3001 12th Avenue North

Fleurimont, Quebec, J1H 5N4, Canada

Location

Charles Lemoyne Hospital

Greenfield Park, Quebec, J4V 2H1, Canada

Location

CHUM - Hopital Notre-Dame

Montreal, Quebec, H2L 4M1, Canada

Location

Montreal Neurological Institute, 3801 University Street

Montreal, Quebec, H3A 2B4, Canada

Location

The Ottawa General Hospital, 501 Smyth Rd.

Ottawa, K1H 8L6, Canada

Location

Private Clinic, 48 Sidi Gaber St.

Alexandria, Egypt

Location

35, Dokki St., Apt. 4

Cairo, Egypt

Location

Al Azhar University, 11 Talaat Harb St, Fourth Floor, Apt 18

Cairo, Egypt

Location

Private Clinic, 35 Dokki St., Apt. 4

Cairo, Egypt

Location

Private Clinic, 7 Batal Ahmed Abdelaziz St Abdeen

Cairo, Egypt

Location

Hopital La Timone Cpcet, Rue Jean Moulin

Marseille, 13385, France

Location

Hopital Central, 29 Avenue du Marechal de Lattre de Tassigny

Nancy, 54035, France

Location

Hôpital Pellegrin

Place Amélie Raba Léon, Bordeaux Cedex, 33076, France

Location

Hopital De Purpan

Place Du Dr. Baylac, Toulouse Cedex, 31059, France

Location

Centre Hospitalier de Poissy, 10 rue du Champ Gaillard

Poissy, 78303, France

Location

Hoppital Pasteur, Archet II, 30 avenue de la Voie

Romaine, 06602, France

Location

Investigational Site

Bamberg, 96049, Germany

Location

Investigational Site

Berlin, 10713, Germany

Location

Investigational Site

Berlin, 13439, Germany

Location

Investigational Site

Bremen, 28177, Germany

Location

Investigational Site

Buchholz, 21244, Germany

Location

Investigational Site

Cologne, 51109, Germany

Location

Investigational Site

Dresden, 01307, Germany

Location

Investigational Site

Düsseldorf, 40225, Germany

Location

Investigational Site

Erbach/Odenwald, 64711, Germany

Location

Investigational Site

Essen, 45122, Germany

Location

Investigational Site

Freiburg im Breisgau, 79106, Germany

Location

Investigational Site

Greifswald, 17475, Germany

Location

Investigational Site

Hamburg, 66421, Germany

Location

Investigational Site

Hanover, 30623, Germany

Location

Investigational Site

Heidelberg, 69120, Germany

Location

Investigational Site

Hennigsdorf, 16761, Germany

Location

Investigational Site

Lengerich, 49525, Germany

Location

Investigational Site

Mainz, 55131, Germany

Location

Investigational Site

München, 80331, Germany

Location

Investigational Site

München, 81675, Germany

Location

Investigational Site

Potsdam, 14471, Germany

Location

Investigational Site

Teupitz, 15755, Germany

Location

Investigational Site

Trier, 54292, Germany

Location

Investigational Site

Tübingen, 72076, Germany

Location

Investigational Site

Ulm, 89073, Germany

Location

Investigational Site

Ulm, 89075, Germany

Location

Investigational Site

Wermsdorf, 04779, Germany

Location

Investigational Site

Würzburg, 97070, Germany

Location

Univ. Hospital of Heraklion

Voutes, Heraklion, Crete, GR 71001, Greece

Location

Errikos Dinan General Hospital, 107 Mesogion Ave.

Athens, 11526, Greece

Location

General Hospital of Athens G. Gennimatas, 154 Mesogeion Ave.

Athens, G-156 69, Greece

Location

Metropolitan Hospital, Ethnarchou Makariou 6 & Eleftheriou Venizelou 1

Athens, GR 18547, Greece

Location

General University Hospital of Patra-RIO

Patra - RIO, GR- 26500, Greece

Location

Ahepa University General Hospital of Thessaloniki, 1 Stilp. Kyriakidi Str.

Thessaloniki, GR 54636, Greece

Location

Debreceni Egyetem Orvos es Egszstd. Centr.

Debrecen, 4012, Hungary

Location

Petz Aladár Megyei Oktató Kórház

Győr, 9024, Hungary

Location

Veszprem Megyei Csolnoky Ferenc Korhaz

Korhaz U. 1, Veszprem, H-8200, Hungary

Location

Pecsi Tudomanyegyetem Neurologiai Klinika

Pécs, 7623, Hungary

Location

Peterfy Sandor u. Hospital, Neurology

U. 8-20m, Budapest, 1076, Hungary

Location

Uzsoki korhaz

Uzsoki U. 29., Budapest, 1145, Hungary

Location

Azienda Sanitaria Osp. S. Luigi

Gonzaga, Orbassano, TO 10043, Italy

Location

Ospedale S. Antonio Abate

Via Pastori, 4, Gallarate, VA, 21013, Italy

Location

Presidio Ospedaliero Roberto Binaghi

Cagliari, CA 09126, Italy

Location

Azienda Ospedaliera Universitaria Arcispedale Sant'Anna

Ferrara, FE 44100, Italy

Location

Presidio Ospedaliero di Vaio Fidenza

Fidenza, PR 43036, Italy

Location

Osp. Magg. Pol. Mangiagalli e Regina Elena - Fond. IRCCS

Milan, MI 20122, Italy

Location

Az. Osp. Niguarda Ca' Granda

Milan, MI 20162, Italy

Location

Presidio Ospedaliero di Montichiari

Montichiari, BS 25018, Italy

Location

IRCCS Neurologico C. Mondino

Pavia, PV 27100, Italy

Location

Az. Osp. Ospedale Consorziale e Policlinico

Piazza Giulio Cesare, 11 Bari, 70124, Italy

Location

Az. Osp. Ospedale S. Martino - Università degli Studi

Via Antonio de Toni, 5, Genova, 16132, Italy

Location

Ist. Neurol. Mediterraneo Neuromed

Via Atinense, 18, Pozzilli, 86077, Italy

Location

Ospedali Riuniti Umberto I - GM Lancisi - G.Salesi

Via Conca, 71, Torrette Di Ancona, 60020, Italy

Location

Osp. Clinicizzato Colle dell'Ara - Università G. D'Annunzio

Via Dei Vestini, 5 Chieti, 66100, Italy

Location

Azienda Ospedaliera Sant'Andrea - Università La Sapienza

Via Di Grottarossa, 1035/1039, Roma, 00189, Italy

Location

Azienda Ospedaliera di Padova - Università degli Studi

Via Giustiniani, 2, Padova, 35128, Italy

Location

Az. Osp. Universitaria Policlinico Tor Vergata

Via Montpellier, 1, Roma, 00133, Italy

Location

Ospedale San Raffaele - IRCCS

Via Olgettina, 48/60, Milano, 20132, Italy

Location

Policlinico - Università degli Studi Federico II

Via Pansini, 5, Napoli, 80131, Italy

Location

Istituto di Scienze Neurologiche Università di Catania

Via Santa Sofia, 78, Catania, 95123, Italy

Location

Ospedale Bellaria Maggiore

Via Toscana Nazionale, 17/19, Bologna, 40139, Italy

Location

Azienda Ospedaliera Careggi - Università degli Studi

Viale Giovan Battista Morgagni, 85, Firenze, 50134, Italy

Location

Hospital Fernando Fonseca

Amadora, 2720-276, Portugal

Location

Hospitais da Universidade de Coimbra

Av. Dr. Bissaya Barreto, Coimbra, 3000-075, Portugal

Location

Hospital Sto. António dos

Capuchos, Portugal

Location

Hospital de São João

Porto, 4200-319, Portugal

Location

Hospital de S. Bernardo

Rua Camilo Castelo Branco, Setubal, 2910-446, Portugal

Location

National Cancer Center, 809 Madu 1-dong, Ilsan-gu

Kyunggi, Goyang, 411-764, South Korea

Location

Samsung Medical Center

Seoul, Korea, 135-710, South Korea

Location

Yonsei Univ. Med. Center,Severance Hospital, 134 Shinchon-dong, Suedaemoon-ku

Seoul, 135-230, South Korea

Location

Kyung Pook National University Hospital

Taegu, 700-721, South Korea

Location

Complejo Hospitalario Carlos Haya

Avda. Carlos Haya, S/n, Málaga, 29010, Spain

Location

Hospital Universitario Virgen Macarena

Avenida Dr. Fedriani, 3, Sevilla, 41009, Spain

Location

Ciutat Sanitaria I, Universitaria De Bellvitge, c/o Feixa Llarga, Hospitalet de Llobregat

Barcelona, 08907, Spain

Location

Hospital de Basurto

Bilbao, 48013, Spain

Location

Hospital Clinico San Carlos

C/ Dr. Martin Lagos, S/n, Madrid, 28040, Spain

Location

Unitat de Neuroimmunologia Clinica, Hospital Vall d'Hebron

EUI-planta 2, Pg. Vall d'Hebron 119-29, Barcelona, 08035, Spain

Location

Puerta de Huerro Univeristy Hospital

San Martin de Porres, 4, Madrid, 28035, Spain

Location

Hospital Universitario La Fe.

Valencia, 46009, Spain

Location

Universitätsspital Zuerich

Neurologische Klinik, Frauenklinikstrasse 26, Zuerich, 8091, Switzerland

Location

Universitätsspital Basel, Neurochirugishen Poliklinik

Petersgraben 4, Basel, 4031, Switzerland

Location

Novartis

Investigational Site, United Kingdom

Location

Charing Cross Hospital

London, W8 6RF, United Kingdom

Location

The Walton Centre for Neurology and Neurosurgery

Lower Lane, Fazakerly, Liverpool, L9 7LJ, United Kingdom

Location

Norfolk & Norwich University Hospital

Norwick, NR4 7UY, United Kingdom

Location

Related Publications (7)

  • Cohen JA, Khatri B, Barkhof F, Comi G, Hartung HP, Montalban X, Pelletier J, Stites T, Ritter S, von Rosenstiel P, Tomic D, Kappos L; TRANSFORMS (TRial Assessing injectable interferoN vS. FTY720 Oral in RRMS) Study Group. Long-term (up to 4.5 years) treatment with fingolimod in multiple sclerosis: results from the extension of the randomised TRANSFORMS study. J Neurol Neurosurg Psychiatry. 2016 May;87(5):468-75. doi: 10.1136/jnnp-2015-310597. Epub 2015 Jun 25.

  • Khatri BO, Pelletier J, Kappos L, Hartung HP, Comi G, Barkhof F, von Rosenstiel P, Meng X, Grinspan A, Hashmonay R, Cohen JA; TRANSFORMS Study Group. Effect of prior treatment status and reasons for discontinuation on the efficacy and safety of fingolimod vs. interferon beta-1a intramuscular: Subgroup analyses of the Trial Assessing Injectable Interferon vs. Fingolimod Oral in Relapsing-Remitting Multiple Sclerosis (TRANSFORMS). Mult Scler Relat Disord. 2014 May;3(3):355-63. doi: 10.1016/j.msard.2013.11.006. Epub 2013 Dec 12.

  • Chinea Martinez AR, Correale J, Coyle PK, Meng X, Tenenbaum N. Efficacy and safety of fingolimod in Hispanic patients with multiple sclerosis: pooled clinical trial analyses. Adv Ther. 2014 Oct;31(10):1072-81. doi: 10.1007/s12325-014-0154-4. Epub 2014 Sep 23.

  • Zarbin MA, Jampol LM, Jager RD, Reder AT, Francis G, Collins W, Tang D, Zhang X. Ophthalmic evaluations in clinical studies of fingolimod (FTY720) in multiple sclerosis. Ophthalmology. 2013 Jul;120(7):1432-9. doi: 10.1016/j.ophtha.2012.12.040. Epub 2013 Mar 24.

  • Khatri B, Barkhof F, Comi G, Hartung HP, Kappos L, Montalban X, Pelletier J, Stites T, Wu S, Holdbrook F, Zhang-Auberson L, Francis G, Cohen JA; TRANSFORMS Study Group. Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study. Lancet Neurol. 2011 Jun;10(6):520-9. doi: 10.1016/S1474-4422(11)70099-0. Epub 2011 May 13.

  • Twiss J, Doward LC, McKenna SP, Eckert B. Interpreting scores on multiple sclerosis-specific patient reported outcome measures (the PRIMUS and U-FIS). Health Qual Life Outcomes. 2010 Oct 11;8:117. doi: 10.1186/1477-7525-8-117.

  • Cohen JA, Barkhof F, Comi G, Hartung HP, Khatri BO, Montalban X, Pelletier J, Capra R, Gallo P, Izquierdo G, Tiel-Wilck K, de Vera A, Jin J, Stites T, Wu S, Aradhye S, Kappos L; TRANSFORMS Study Group. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med. 2010 Feb 4;362(5):402-15. doi: 10.1056/NEJMoa0907839. Epub 2010 Jan 20.

Related Links

MeSH Terms

Conditions

Multiple Sclerosis

Interventions

Fingolimod Hydrochloride

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNSAutoimmune Diseases of the Nervous SystemNervous System DiseasesDemyelinating DiseasesAutoimmune DiseasesImmune System Diseases

Intervention Hierarchy (Ancestors)

SphingosineAmino AlcoholsAlcoholsOrganic ChemicalsPropylene GlycolsGlycolsAmines

Results Point of Contact

Title
Study Director
Organization
Novartis Pharmaceuticals

Study Officials

  • Novartis Pharmaceuticals

    Novartis Pharmacuticals

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 19, 2006

First Posted

June 21, 2006

Study Start

May 1, 2006

Primary Completion

July 1, 2011

Study Completion

July 1, 2011

Last Updated

September 21, 2017

Results First Posted

May 16, 2011

Record last verified: 2017-08

Locations