Manipulation of L-Ascorbic Acid Level For The Treatment of Selected Cases Of Acute Myeloid Leukemia and Myelodysplastic Syndromes
Sponsor study identifier
interventional
25
1 country
1
Study Start
May 1998
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
August 2005
Date type not reportedThis date has not been verified as actual or estimated.
To document therapeutic gain achieved by cyclic application of L-ascorbic acid (LAA) supplementation and depletion, while confirming safety and avoidance of clinically significant scurvy, in chemorefractory patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2005
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 1998
Date type not reportedThis date has not been verified as actual or estimated.
August 2005
Date type not reportedThis date has not been verified as actual or estimated.
May 22, 2006
Actual (reported)May 24, 2006
Actual (reported)Efficacy
Safety, clinically
Correlative studies between the modulation of the growth of leukemic colony-forming-cells(CFC) by L-ascorbic acid (LAA) in cell-culture and clinical response.
Samsung Medical Center
Seoul, South Korea
Park CH, Kimler BF, Yi SY, Park SH, Kim K, Jung CW, Kim SH, Lee ER, Rha M, Kim S, Park MH, Lee SJ, Park HK, Lee MH, Yoon SS, Min YH, Kim BS, Kim JA, Kim WS. Depletion of L-ascorbic acid alternating with its supplementation in the treatment of patients with acute myeloid leukemia or myelodysplastic syndromes. Eur J Haematol. 2009 Aug;83(2):108-18. doi: 10.1111/j.1600-0609.2009.01252.x. Epub 2009 Mar 5.
Won Seog Kim, MD
Samsung Medical Center
First Submitted
May 22, 2006
First Posted
May 24, 2006
Study Start
May 1998
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
August 2005
Date type not reportedContact the study team to confirm eligibility.
This date has not been verified as actual or estimated.
Last Updated
October 26, 2006
Record last verified: 2006-10
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