Fluid Shifts During Resuscitation: Impacts on Macrocirculation and Microcirculation

NCT00326729 | Unknown

• 1 other identifier: HD06-004
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Fluid resuscitation in burn patients is associated with major macrocirculatory and microcirculatory disturbances that have been poorly described. When done according to expert opinions, it is now rare to encounter the death of a patient due to an inadequate fluid resuscitation. Fluid resuscitation in burn patients is more opinion-based than evidence-based. Although burn admission to an intensive care facility is relatively rare, the burn patient is well suited to answer questions in the fluid resuscitation field because, as opposed to other critically ill patients:

1. 1.investigators do have a time 'zero' for burn patients; they know exactly when the insult occurred;
2. 2.apart from fluid resuscitation, the management of burn patients is uniform in the investigators' unit and is done according to various protocols;
3. 3.the burn population is more uniform than the septic population making confounders and background noises less likely; and
4. 4.as basic as it might sound, studying fluid resuscitation implies accomplishing a significant one; burn patients are the category of critically ill patients receiving the most important fluid resuscitation.
5. 5.fluid accumulation during the initial phase; and
6. 6.short term effects of colloids on macrocirculatory and microcirculatory parameters.
7. 7.At defined time points: a set of data (see below) will be collected by the research team at baseline, 6, 12, 18, 24, 36, 48 and 72 hours after burn injury. Baseline values will be the ones obtained immediately after consent.
8. 8.Fluid challenges: Burn patients often require additional fluid bolus to maintain hemodynamic stability because of the following reasons: hypotension; decreased urine output (less than 0.5 ml/kg/hour); uncorrected metabolic acidosis; rhabdomyolysis; increasing hematocrit; or any other clinical reason according to the attending physician.

Conditions

Burns

Keywords

burns; thermal injury; hemodynamics; microcirculation

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Major thermal, electrical, or chemical burns
• Admission to the burn unit within 6 hours after burn
• Burned surface area over 20% or equivalent
• Signed consent by the patient or relative
• Commitment to full maximal support

You may not qualify if:

• Patient under 18 years old
• Patient over 80 years old
• Pregnancy
• Chronic renal failure requiring dialysis

Sponsors & Collaborators

• Montreal Burn Centre: lead
• Bristol-Myers Squibb: collaborator
• Canadian Anesthesiologists' Society: collaborator

Study Sites (1)

Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2W1T8, Canada

RECRUITING

MeSH Terms

Conditions

Burns

Condition Hierarchy (Ancestors)

Wounds and Injuries

Study Officials

• David Bracco, MD

  Centre Hospitalier de l'Universite de Montreal

  PRINCIPAL INVESTIGATOR

• Marc-Jacques Dubois, MD

  Centre Hospitalier de l'Universite de Montreal

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Patrice Deroy

CONTACT

514-890-8000; patrice.deroy.chum@ssss.gouv.qc.ca

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 15, 2006
• First Posted: May 17, 2006
• Study Start: May 1, 2006
• Last Updated: June 16, 2006

Record last verified: 2006-05

Locations

CA (1)