Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion

NCT00313066 | Unknown

• 1 other identifier: 940513/C05092
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Connective tissue growth factor (CTGF) is known to be a fibrogenic cytokine, it could be expressed in various fibrosis diseases. But, recent research showed that CTGF also be considered to be a tumor suppressive gene. The expression of CTGF protein is higher in normal Type I and II alveolar epithelial cells than metastatic tumor cells. CTGF appears to be a suppressor of lung tumor invasion and in metastasis and the decreased CTGF expression in tumor tissues was associated with advanced tumor stage, lymph node metastasis, early postoperative relapse and shorter patient survival. CTGF can be expressed in many human organs such as heart, brain, placenta, liver, muscle, kidney, peritoneal mesothelial cells and lung but did not known in the pleura. The CTGF protein is present in the peritoneal cavity and is increased during peritonitis. Considering pleural cavity comes from the same origin of mesenchyma with peritoneum, pericardium and fallopian tube, we aim to evaluate whether the CTGF expression increase in the pleurisy patients including the parapneumonic effusion and the TB pleurisy. The diagnosis of TB pleurisy depends on the effusion TB culture and pleural biopsy. Unfortunately the sensitivity of TB culture was only 20-30%. So most patients must receive invasive pleural biopsy. Adenosine deaminase(ADA) was developed as a screening test but should not be considered an alternative test to culture and biopsy. The sensitivity of ADA might vary from 32%-100% and the cutoff value also vary from 26 to 70 IU/L. We should develop a method to alternate the culture and biopsy . Therefore, our technologist Jao-Jia chu will develop the CTGF ELISA kit for this specific aim. If CGTF might increase expression in pleuritis but decrease in pleural metastasis, it might be a potential method help to differentiate lymphocytic pleural effusion between TB pleurisy and malignancy.

Conditions

Tuberculosis; Tuberculous Pleurisy; Malignant Pleural Effusion; Empyema

Keywords

CTGF; fibrogenic cytokine; FGF; pleural fibrosis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- patients with pleural effusion

You may not qualify if:

• HIV infection

Sponsors & Collaborators

• Taichung Veterans General Hospital: lead
• Ton General Hospital: collaborator

Study Sites (1)

Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital

Taichung, Taiwan, 407, China

RECRUITING

MeSH Terms

Conditions

Tuberculosis; Tuberculosis, Pleural; Pleural Effusion, Malignant; Empyema

Condition Hierarchy (Ancestors)

Mycobacterium Infections; Actinomycetales Infections; Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Tuberculosis, Extrapulmonary; Respiratory Tract Infections; Pleural Diseases; Respiratory Tract Diseases; Pleural Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Pleural Effusion; Suppuration; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Shen Gwan Han, MD

  Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shen Gwan Han, MD

CONTACT

+886-4-23592525; 911B@vghtc.gov.tw

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 9, 2006
• First Posted: April 11, 2006
• Study Start: November 1, 2005
• Study Completion: November 1, 2006
• Last Updated: April 11, 2006

Record last verified: 2006-04

Locations

CN (1)