Combined Behavioral and Pharmacologic Treatment of Polydrug Abuse

NCT00292123 | Completed Phase 1

• 1 other identifier: NIDAIRP 326
• Study Type: interventional
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

The primary goal of this study is to determine how contingency management can best be combined with standard or high doses of methadone to increase simultaneous abstinence from heroin and cocaine.

Conditions

Opioid Dependence; Cocaine Abuse

Interventions

Methadone DRUG

Contingency Management BEHAVIORAL

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Opioid dependence; cocaine use

You may not qualify if:

• Medical or psychiatric conditions that would contraindicate participation in a methadone maintenance study; inability to give informed consent; inability to attend clinic seven days a week

Sponsors & Collaborators

• National Institute on Drug Abuse (NIDA): lead

Related Publications (7)

• Ghitza UE, Epstein DH, Preston KL. Contingency management reduces injection-related HIV risk behaviors in heroin and cocaine using outpatients. Addict Behav. 2008 Apr;33(4):593-604. doi: 10.1016/j.addbeh.2007.11.009. Epub 2007 Nov 17.

  PMID: 18068905 RESULT

• Willner-Reid J, Belendiuk KA, Epstein DH, Schmittner J, Preston KL. Hepatitis C and human immunodeficiency virus risk behaviors in polydrug users on methadone maintenance. J Subst Abuse Treat. 2008 Jul;35(1):78-86. doi: 10.1016/j.jsat.2007.08.011. Epub 2007 Oct 10.

  PMID: 17931826 RESULT

• Ghitza UE, Epstein DH, Schmittner J, Vahabzadeh M, Lin JL, Preston KL. Randomized trial of prize-based reinforcement density for simultaneous abstinence from cocaine and heroin. J Consult Clin Psychol. 2007 Oct;75(5):765-74. doi: 10.1037/0022-006X.75.5.765.

  PMID: 17907858 RESULT

• Ghitza UE, Epstein DH, Preston KL. Psychosocial functioning and cocaine use during treatment: strength of relationship depends on type of urine-testing method. Drug Alcohol Depend. 2007 Dec 1;91(2-3):169-77. doi: 10.1016/j.drugalcdep.2007.05.018. Epub 2007 Jul 10.

  PMID: 17624688 RESULT

• Heinz A, Epstein DH, Preston KL. Spiritual/Religious experiences and in-treatment outcome in an inner-city program for heroin and cocaine dependence. J Psychoactive Drugs. 2007 Mar;39(1):41-9. doi: 10.1080/02791072.2007.10399863.

  PMID: 17523584 RESULT

• Heinz AJ, Epstein DH, Schroeder JR, Singleton EG, Heishman SJ, Preston KL. Heroin and cocaine craving and use during treatment: measurement validation and potential relationships. J Subst Abuse Treat. 2006 Dec;31(4):355-64. doi: 10.1016/j.jsat.2006.05.009. Epub 2006 Aug 1.

  PMID: 17084789 RESULT

• Ghitza UE, Epstein DH, Preston KL. Nonreporting of cannabis use: Predictors and relationship to treatment outcome in methadone maintained patients. Addict Behav. 2007 May;32(5):938-49. doi: 10.1016/j.addbeh.2006.06.034. Epub 2006 Aug 1.

  PMID: 16887281 RESULT

MeSH Terms

Conditions

Opioid-Related Disorders; Cocaine-Related Disorders

Interventions

Methadone

Condition Hierarchy (Ancestors)

Narcotic-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Ketones; Organic Chemicals

Study Officials

• Kenzie Preston, PhD

  NIFA Intramural Research Program

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NIH

Study Record Dates

• First Submitted: February 14, 2006
• First Posted: February 15, 2006
• Study Start: June 1, 1999
• Primary Completion: June 1, 2006
• Study Completion: August 1, 2006
• Last Updated: January 12, 2017

Record last verified: 2007-12