Success Metrics

Clinical Success Rate
84.6%

Based on 88 completed trials

Completion Rate
85%(88/104)
Active Trials
19(13%)
Results Posted
41%(36 trials)
Terminated
16(11%)

Phase Distribution

Ph not_applicable
15
10%
Ph phase_1
26
18%
Ph early_phase_1
3
2%
Ph phase_3
28
19%
Ph phase_4
45
31%
Ph phase_2
18
13%

Phase Distribution

29

Early Stage

18

Mid Stage

73

Late Stage

Phase Distribution135 total trials
Early Phase 1First-in-human
3(2.2%)
Phase 1Safety & dosage
26(19.3%)
Phase 2Efficacy & side effects
18(13.3%)
Phase 3Large-scale testing
28(20.7%)
Phase 4Post-market surveillance
45(33.3%)
N/ANon-phased studies
15(11.1%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

79.3%

88 of 111 finished

Non-Completion Rate

20.7%

23 ended early

Currently Active

19

trials recruiting

Total Trials

144

all time

Status Distribution
Active(24)
Completed(88)
Terminated(23)
Other(9)

Detailed Status

Completed88
Recruiting16
Terminated16
unknown9
Withdrawn7
Not yet recruiting4

Development Timeline

Analytics

Development Status

Total Trials
144
Active
19
Success Rate
84.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (2.2%)
Phase 126 (19.3%)
Phase 218 (13.3%)
Phase 328 (20.7%)
Phase 445 (33.3%)
N/A15 (11.1%)

Trials by Status

active_not_recruiting32%
enrolling_by_invitation11%
recruiting1611%
unknown96%
withdrawn75%
terminated1611%
not_yet_recruiting43%
completed8861%

Recent Activity

Clinical Trials (144)

Showing 20 of 144 trialsScroll for more
NCT07528508Phase 1

A Clinical Trial in Healthy Participants to Study the Effect of a Single Dose of MK-8527 on Levels of Methadone (MK-8527-020)

Recruiting
NCT07595263Phase 1

A Study of Ulonivirine (MK-8507) and Methadone in Healthy Volunteers (MK-8507-019)

Not Yet Recruiting
NCT06323824Phase 4

Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

Recruiting
NCT06810336Early Phase 1

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery

Recruiting
NCT06784999Phase 4

Sufentanil Infusion vs Intravenous Methadone for Postoperative Analgesia Following Head and Neck Dissection With Free Flap or Rotational Reconstruction

Recruiting
NCT07546396Phase 4

Methadone Rapid Restart

Not Yet Recruiting
NCT03574792Phase 2

Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy

Completed
NCT07517679Phase 4

Methadone for Post-operative Spine Surgery

Not Yet Recruiting
NCT07485803Phase 4

A RCT Using Methadone in the Management of Post-Operative Pain in Total Knee Replacement

Not Yet Recruiting
NCT05905367Phase 4

Symptom-inhibited Fentanyl Induction

Completed
NCT06525740Phase 4

Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery

Recruiting
NCT07227064Phase 3

Methadone in THA for Post-op Pain and Opioid Reduction

Recruiting
NCT05417100Phase 3

Understanding How Methadone Treatment During Surgery Affects Pain Levels and the Need for Pain Medications After Surgery

Active Not Recruiting
NCT06536517Phase 2

The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.

Recruiting
NCT07222072Phase 4

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

Recruiting
NCT06576830Phase 4

Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia

Recruiting
NCT02025855Phase 4

Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit

Terminated
NCT03726268Phase 4

Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)

Completed
NCT06868589Phase 4

Reducing Pain With Methadone and Ketamine in Liver Transplant

Recruiting
NCT06387303Early Phase 1

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
144