Success Metrics

Clinical Success Rate
84.6%

Based on 88 completed trials

Completion Rate
85%(88/104)
Active Trials
17(12%)
Results Posted
41%(36 trials)
Terminated
16(11%)

Phase Distribution

Ph phase_2
18
13%
Ph not_applicable
15
11%
Ph early_phase_1
3
2%
Ph phase_1
25
18%
Ph phase_3
28
20%
Ph phase_4
44
31%

Phase Distribution

28

Early Stage

18

Mid Stage

72

Late Stage

Phase Distribution133 total trials
Early Phase 1First-in-human
3(2.3%)
Phase 1Safety & dosage
25(18.8%)
Phase 2Efficacy & side effects
18(13.5%)
Phase 3Large-scale testing
28(21.1%)
Phase 4Post-market surveillance
44(33.1%)
N/ANon-phased studies
15(11.3%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

79.3%

88 of 111 finished

Non-Completion Rate

20.7%

23 ended early

Currently Active

17

trials recruiting

Total Trials

142

all time

Status Distribution
Active(22)
Completed(88)
Terminated(23)
Other(9)

Detailed Status

Completed88
Terminated16
Recruiting14
unknown9
Withdrawn7
Not yet recruiting4

Development Timeline

Analytics

Development Status

Total Trials
142
Active
17
Success Rate
84.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (2.3%)
Phase 125 (18.8%)
Phase 218 (13.5%)
Phase 328 (21.1%)
Phase 444 (33.1%)
N/A15 (11.3%)

Trials by Status

unknown96%
completed8862%
enrolling_by_invitation11%
recruiting1410%
not_yet_recruiting43%
terminated1611%
withdrawn75%
active_not_recruiting32%

Recent Activity

Clinical Trials (142)

Showing 20 of 142 trialsScroll for more
NCT06323824Phase 4

Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

Recruiting
NCT03574792Phase 2

Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy

Completed
NCT07528508Phase 1

A Clinical Trial in Healthy Participants to Study the Effect of a Single Dose of MK-8527 on Levels of Methadone (MK-8527-020)

Not Yet Recruiting
NCT07517679Phase 4

Methadone for Post-operative Spine Surgery

Not Yet Recruiting
NCT07485803Phase 4

A RCT Using Methadone in the Management of Post-Operative Pain in Total Knee Replacement

Not Yet Recruiting
NCT05905367Phase 4

Symptom-inhibited Fentanyl Induction

Completed
NCT06525740Phase 4

Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery

Recruiting
NCT07227064Phase 3

Methadone in THA for Post-op Pain and Opioid Reduction

Recruiting
NCT05417100Phase 3

Understanding How Methadone Treatment During Surgery Affects Pain Levels and the Need for Pain Medications After Surgery

Active Not Recruiting
NCT06536517Phase 2

The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.

Recruiting
NCT07222072Phase 4

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

Recruiting
NCT06576830Phase 4

Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia

Recruiting
NCT02025855Phase 4

Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit

Terminated
NCT03726268Phase 4

Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)

Completed
NCT06868589Phase 4

Reducing Pain With Methadone and Ketamine in Liver Transplant

Recruiting
NCT06387303Early Phase 1

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery

Recruiting
NCT05075265

Methadone in Adults Undergoing Cardiac Surgery

Completed
NCT06784999Phase 4

Sufentanil Infusion vs Intravenous Methadone for Postoperative Analgesia Following Head and Neck Dissection With Free Flap or Rotational Reconstruction

Recruiting
NCT05913284Phase 3

Intravenous Methadone in Perioperative Acute and Chronic Management in Chinese Adult Cardiac Surgical Patients

Active Not Recruiting
NCT05786599Phase 2

Methadone to Treat Painful Chemotherapy Induced Peripheral Neuropathy

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
142