Transcranial Magnetic Stimulation (TMS) Treatment for Patients With Persistent Auditory Hallucinations
TMS Intervention Development for Auditory Hallucinations
2 other identifiers
interventional
50
1 country
1
Brief Summary
This study will evaluate the long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with auditory hallucinations.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable schizophrenia
Started Jul 2002
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2002
CompletedFirst Submitted
Initial submission to the registry
July 24, 2002
CompletedFirst Posted
Study publicly available on registry
July 26, 2002
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2003
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2004
CompletedAugust 6, 2013
August 1, 2013
1 year
July 24, 2002
August 2, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Hallucination Change Score
2 weeks
Secondary Outcomes (3)
Total AHRS score
2 weeks
CGI
2 weeks
Frequency subscale of AHRS
2 weeks
Interventions
1 Hertz stimulation for 16 minutes per day at 90% motor threshold, 5 sessions each to the two primary cortical targets
Eligibility Criteria
You may qualify if:
- Have persistent auditory hallucinations
You may not qualify if:
- History of neurological disorder
- Serious, unstable medical conditions (persons with hypertension or diabetes mellitus may enroll if these conditions are treated and stable)
- Active drug or alcohol abuse (persons may enroll if they have a history of drug or alcohol abuse provided that they do not use these substances at least 4 weeks prior to study initiation)
- History of seizures unrelated to drug withdrawal
- Estimated IQ less than 80
- Have a sibling or parent with epilepsy
- Disorganized thought process or intellectual impairment that inhibits the ability to give an informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Yale Universitylead
- National Institute of Mental Health (NIMH)collaborator
Study Sites (1)
Yale-New Haven Psychiatric Hospital
New Haven, Connecticut, 06519, United States
Related Publications (3)
Hoffman RE, Boutros NN, Hu S, Berman RM, Krystal JH, Charney DS. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. Lancet. 2000 Mar 25;355(9209):1073-5. doi: 10.1016/S0140-6736(00)02043-2.
PMID: 10744097BACKGROUNDHoffman RE, Hawkins KA, Gueorguieva R, Boutros NN, Rachid F, Carroll K, Krystal JH. Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations. Arch Gen Psychiatry. 2003 Jan;60(1):49-56. doi: 10.1001/archpsyc.60.1.49.
PMID: 12511172BACKGROUNDHoffman RE, Gueorguieva R, Hawkins KA, Varanko M, Boutros NN, Wu YT, Carroll K, Krystal JH. Temporoparietal transcranial magnetic stimulation for auditory hallucinations: safety, efficacy and moderators in a fifty patient sample. Biol Psychiatry. 2005 Jul 15;58(2):97-104. doi: 10.1016/j.biopsych.2005.03.041.
PMID: 15936729RESULT
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
July 24, 2002
First Posted
July 26, 2002
Study Start
July 1, 2002
Primary Completion
July 1, 2003
Study Completion
June 1, 2004
Last Updated
August 6, 2013
Record last verified: 2013-08