Treatment Effects From Aerobic Endurance Training and Maximal Strength Training in Patients Suffering From Schizophrenia

NCT00286299 | Completed

• 1 other identifier: 4.2005.1507
• Study Type: interventional
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates treatment effects from aerobic endurance training, maximal strength training and computer game on aerobic capacity, work efficiency and psychiatric symptoms in patients suffering from schizophrenia. The study is a controlled trial. The aim is to describe the population in respect to aerobic capacity and muscular strength. Low aerobic capacity and muscular strength are important risk factors for cardiovascular disease (CVD). The study also aim to evaluate physical and psychiatric effects from physical training. Effects from participation in physical training or computer game on symptoms, depression and quality of life will be investigated. Data will be collected between October 2005 and August 2007.

Conditions

Schizophrenia; Cardiovascular Disease

Keywords

Schizophrenia; Cardiovascular disease; Aerobic capacity; Mortality; Exercise

Outcome Measures

Primary Outcomes (1)

• peak aerobic capacity (VO2peak)

  Pre- and Posttest

Secondary Outcomes (6)

• Positive and Negative Syndrome Scale (PANSS)

  Pre- and Posttest

• Calgary Depression Scale for Schizophrenia (CDSS)

  Pre- and Posttest

• The 36-item short form (SF-36)

  Pre- and Posttest

• 60 Watt walking efficiency, Net efficiency

  Pre- and Posttest

• Maximal strength, measured as one repetition maximum (1RM) in a incline leg press machine (Technogym)

  Pre- and Post test

Study Arms (3)

Aerobic interval training (AIT)

EXPERIMENTAL

AIT is 4x4 minutes interval training on a treadmill at 85 to 95 % HRpeak interspersed with 3 min of active resting periods at a work load corresponding to 70 % HRpeak between each interval. Patients performed the intervals walking or running with a minimum of 5 % inclination.

Other: Aerobic high-intensity interval training (AIT)

Computer game training (CG)

ACTIVE COMPARATOR

36 minutes playing supervised computer games, Tetris, Xbox

Other: Computer game training (CG)

Maximal strength training (MST)

EXPERIMENTAL

MST is performed in a leg press machine. The weight is lowered in a controlled manner in the eccentric phase until the patient reached 90 degrees in the knee joint. Then the patients has a short stop (\~0.5 second) before the weight is moved as rapidly as possible to complete extension. The training volume is 4 sets of 4RM (i.e. 85-90 % 1RM). The training load is increased with 2.5-5 kg each time patients managed to perform 4 sets with the determined load or each training session.

Other: Maximal strength training

Interventions

Aerobic high-intensity interval training (AIT) OTHER

The AIT group trains 4x4 minute interval training on a treadmill at 85-95 % HRpeak interspersed with 3 minutes of active resting periods at a work load corresponding to 70% HRpeak between each interval. All training sessions are monitored and start with a 6 minute warm-up and end with a 5 minute cool-down period at a work load corresponding to 70% HRpeak. Intervals are performed walking or running on a treadmill with a minimum of 5% inclination, 3 times per week for 8 weeks.

Also known as: 4x4 interval

Aerobic interval training (AIT)

Computer game training (CG) OTHER

The CG spend the same amount of time (36 minutes), training to improve their ability in the computer game, Tetris. Tetris is a game where small shapes called Tetraminoes fall from the top of the Playfield to the bottom. Players must rotate the Tetraminoes as they fall and fit them together to complete lines. When the player fills an entire line with blocks, that line is removed from the screen. If the player cannot complete lines, the blocks will eventually rise past the top of the screen, and the game ends.

Also known as: Tetris THQ Inc., Xbox, Microsoft

Computer game training (CG)

Maximal strength training OTHER

Training starts with a 10 minute warm-up on the treadmill. Maximal strength training is then performed in an inclined leg press machine. The subject lifts 4 maximal repetitions that are repeated 4 times after a 2 minute rest period. Subjects are instructed to lift the weight with an intention of maximal mobilization of force. Training load is increased each time the subject manage to perform 4x4 maximal repetitions. Training is carried out 3 times per week in 8 weeks.

Also known as: Leg press machine (Technogym), Olympic weights (Eleiko)

Maximal strength training (MST)

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

Sponsors & Collaborators

• Norwegian University of Science and Technology: lead
• St. Olavs Hospital: collaborator
• Helse Nord-Trøndelag HF: collaborator

Study Sites (1)

St. Olavs Hospital, Department of Psychiatry

Trondheim, 7041, Norway

Location

Related Publications (1)

• Heggelund J, Nilsberg GE, Hoff J, Morken G, Helgerud J. Effects of high aerobic intensity training in patients with schizophrenia: a controlled trial. Nord J Psychiatry. 2011 Sep;65(4):269-75. doi: 10.3109/08039488.2011.560278. Epub 2011 Feb 18.

  PMID: 21332297 RESULT

MeSH Terms

Conditions

Schizophrenia; Cardiovascular Diseases; Motor Activity

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Behavior

Study Officials

• Geir Nilsberg, M.D.

  Norwegian University og Science and Technology

  STUDY CHAIR

• Jørn Heggelund, M.Sc.

  Norwegian University of Science and Technology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 2, 2006
• First Posted: February 3, 2006
• Study Start: October 1, 2005
• Primary Completion: July 1, 2008
• Study Completion: July 1, 2008
• Last Updated: March 29, 2017

Record last verified: 2017-03

Locations

NO (1)