Fluids and Catheters Treatment Trial (FACTT) - ARDS Clinical Research Network

NCT00281268 | Completed Phase 3

• 1 other identifier: 356
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To assess rapidly innovative treatment methods in patients with adult respiratory distress syndrome as well as those at risk of developing ARDS.

Conditions

Acute Respiratory Distress Syndrome; Lung Diseases

Interventions

pulmonary artery catheter PROCEDURE

central venous catheter PROCEDURE

fluid management PROCEDURE

Eligibility Criteria

• Age: 13 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Men and women, 13 years of age or older, with ARDS or risk factors for ARDS. Patients will be considered at risk if they are critically ill and have trauma, sepsis, shock, pneumonia, inhalation injury, drug overdose, pancreatitis, hypertransfusion.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead
• ARDSNet: collaborator

Related Publications (4)

• Bhatraju P, Hsu C, Mukherjee P, Glavan BJ, Burt A, Mikacenic C, Himmelfarb J, Wurfel M. Associations between single nucleotide polymorphisms in the FAS pathway and acute kidney injury. Crit Care. 2015 Oct 19;19:368. doi: 10.1186/s13054-015-1084-5.

  PMID: 26477820 DERIVED

• Stewart RM, Park PK, Hunt JP, McIntyre RC Jr, McCarthy J, Zarzabal LA, Michalek JE; National Institutes of Health/National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. Less is more: improved outcomes in surgical patients with conservative fluid administration and central venous catheter monitoring. J Am Coll Surg. 2009 May;208(5):725-35; discussion 735-7. doi: 10.1016/j.jamcollsurg.2009.01.026. Epub 2009 Mar 31.

  PMID: 19476825 DERIVED

• National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network; Wheeler AP, Bernard GR, Thompson BT, Schoenfeld D, Wiedemann HP, deBoisblanc B, Connors AF Jr, Hite RD, Harabin AL. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med. 2006 May 25;354(21):2213-24. doi: 10.1056/NEJMoa061895. Epub 2006 May 21.

  PMID: 16714768 DERIVED

• National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network; Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, deBoisblanc B, Connors AF Jr, Hite RD, Harabin AL. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006 Jun 15;354(24):2564-75. doi: 10.1056/NEJMoa062200. Epub 2006 May 21.

  PMID: 16714767 DERIVED

Related Links

• Acute Respiratory Distress Syndrome Clinical Network (ARDSNet)

MeSH Terms

Conditions

Respiratory Distress Syndrome; Lung Diseases

Interventions

Central Venous Catheters

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases; Respiration Disorders

Intervention Hierarchy (Ancestors)

Vascular Access Devices; Catheters; Equipment and Supplies

Study Officials

• Edward Abraham

  University of Colorado, Denver

• Antonio Anzueto

  University of Texas

• Alfred Connors

  University of Virginia

• Bennett deBoisblanc

  Louisiana State University Health Sciences Center in New Orleans

• Michael Donahoe

  University of Pittsburgh

• William Fulkerson

  Duke University

• Kalpalatha Guntupalli

  Baylor College of Medicine

• Robert Hite

  Wake Forest University

• Leonard Hudson

  University of Washington

• Paul Lanken

  University of Pennsylvania

• Michael Matthay

  University of California

• Alan Morris

  Latter Day Saints Hospital

• James Russell

  University of British Columbia

• Gregory Schmidt

  University of Chicago

• David Schoenfeld

  Massachusetts General Hospital

• Henry Silverman

  University of Maryland

• Jay Steingrub

  Baystate Medical Center

• Galen Toews

  University of Michigan

• Arthur Wheeler

  Vanderbilt University

• Herbert Wiedemann

  The Cleveland Clinic

Study Design

• Study Type: interventional
• Phase: phase 3
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: NIH

Study Record Dates

• First Submitted: January 20, 2006
• First Posted: January 24, 2006
• Primary Completion: October 1, 2005
• Study Completion: October 1, 2005
• Last Updated: January 21, 2008

Record last verified: 2008-01