NCT00006496|Active Not Recruiting
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Sponsor study identifier
Secondary identifiers
NIH
observational
4,000
1 country
1
Study Start
February 2000
Actual (reported)Primary Completion
August 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
To examine the possible relationship between genetic factors and the acute respiratory distress syndrome (ARDS).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 2000
Actual (reported)November 16, 2000
Actual (reported)November 17, 2000
Actual (reported)August 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Risk of ARDS
From admission to ICU
Mortality
From admission to ICU to 60 days
Multi-organ Failure
From admission to ICU
All patients admitted to ICU with risk factors for ARDS
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
Gong MN, Wei Z, Xu LL, Miller DP, Thompson BT, Christiani DC. Polymorphism in the surfactant protein-B gene, gender, and the risk of direct pulmonary injury and ARDS. Chest. 2004 Jan;125(1):203-11. doi: 10.1378/chest.125.1.203.
Gong MN, Thompson BT, Williams P, Pothier L, Boyce PD, Christiani DC. Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Crit Care Med. 2005 Jun;33(6):1191-8. doi: 10.1097/01.ccm.0000165566.82925.14.
Blood will be collected for DNA extraction and plasma cytokine measurements
David Christiani, MD
Harvard University School of Public Health
First Submitted
November 16, 2000
First Posted
November 17, 2000
Study Start
February 2000
Actual (reported)Primary Completion
August 2028
EstimatedStudy of the Economics of Pulmonary Artery Catheter Use in Patients With Acute Respiratory Distress Syndrome (ARDS)
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Cao S, Li H, Xin J, Jin Z, Zhang Z, Li J, Zhu Y, Su L, Huang P, Jiang L, Du M, Christiani DC. Identification of genetic profile and biomarkers involved in acute respiratory distress syndrome. Intensive Care Med. 2024 Jan;50(1):46-55. doi: 10.1007/s00134-023-07248-9. Epub 2023 Nov 3.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 7, 2026
Record last verified: 2026-10
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Source: ClinicalTrials.gov.
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