NCT00279981

Brief Summary

The purpose of this study is to look at the heart rate and rhythm information collected daily in Medtronic implantable pulse generators (IPG), implantable cardioverter defibrillators (ICD) and cardiac resynchronization therapy (CRT) devices. The study will gather this information from many patients to see if heart rate or rhythm data can predict the risk of a patient having a medical condition such as stroke.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
3,100

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2003

Typical duration for all trials

Geographic Reach
3 countries

98 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2003

Completed
2.2 years until next milestone

First Submitted

Initial submission to the registry

January 18, 2006

Completed
2 days until next milestone

First Posted

Study publicly available on registry

January 20, 2006

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2007

Completed
Last Updated

December 11, 2008

Status Verified

December 1, 2008

Enrollment Period

3.6 years

First QC Date

January 18, 2006

Last Update Submit

December 10, 2008

Conditions

Keywords

Atrial fibrillationStrokePacemakerImplantable Cardiac DefibrillatorResynchronization systems

Interventions

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Subject provides written informed consent and privacy/protection authorization.
  • Subjects 65 years of age or older.
  • Subjects with age \>18 and \< 65 years and one of the following stroke risk factors:
  • Prior stroke or TIA
  • Diagnosis of hypertension (HTN)
  • Diagnosis of Diabetes Mellitus (DM)
  • Diagnosis of Congestive Heart Failure (CHF)
  • Subjects who meet the Class I/Class II indications for a dual chamber implantable pulse generator or dual chamber implanted cardioverter defibrillator device
  • Subjects who meet the criteria for indication of a dual chamber resynchronization device with bi-ventricular pacing (moderate to severe CHF symptoms \[NYHA Class III-IV\] despite optimal medical therapy, left ventricular ejection fraction ≤ 35%, and a QRS duration ≥130 ms)13.

You may not qualify if:

  • Subjects who are to receive a replacement IPG, ICD or CRT device.
  • Subjects with chronic (permanent) AT/AF.
  • Subjects with a history of AV nodal dependent arrhythmias.
  • Subjects with a terminal illness who are not expected to survive more than 6 months.
  • Subjects who are unwilling or unable to cooperate or give written informed consent and privacy/protection authorization, or subjects whose legal representatives or legal guardians refuse to give informed consent or privacy/protection authorization.
  • Subjects currently receiving treatment in another drug and/or device study which could affect the outcome of the trial.
  • Subjects who are or will be inaccessible for follow-up at a qualified study center.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (98)

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Mesa, Arizona, United States

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Tucson, Arizona, United States

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Fountain Valley, California, United States

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Mission Viejo, California, United States

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Modesto, California, United States

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National City, California, United States

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Palm Springs, California, United States

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Salinas, California, United States

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San Bernadino, California, United States

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Torrance, California, United States

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Norwalk, Connecticut, United States

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Newark, Delaware, United States

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Washington D.C., District of Columbia, United States

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Fort Lauderdale, Florida, United States

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Hollywood, Florida, United States

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Melbourne, Florida, United States

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Naples, Florida, United States

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Palm Beach Gardens, Florida, United States

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St. Petersburg, Florida, United States

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Atlanta, Georgia, United States

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Boise, Idaho, United States

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Chicago, Illinois, United States

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Indianapolis, Indiana, United States

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Munster, Indiana, United States

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Ames, Iowa, United States

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Wichita, Kansas, United States

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Ashland, Kentucky, United States

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Lexington, Kentucky, United States

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Covington, Louisiana, United States

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Slidell, Louisiana, United States

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Baltimore, Maryland, United States

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Hagerstown, Maryland, United States

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Takoma Park, Maryland, United States

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Boston, Massachusetts, United States

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Brighton, Massachusetts, United States

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Burlington, Massachusetts, United States

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Worcester, Massachusetts, United States

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Grand Blanc, Michigan, United States

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Kalamazoo, Michigan, United States

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Mount Clemens, Michigan, United States

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Saginaw, Michigan, United States

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Duluth, Minnesota, United States

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Minneapolis, Minnesota, United States

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Saint Paul, Minnesota, United States

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Gulfport, Mississippi, United States

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Hattiesburg, Mississippi, United States

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Tupelo, Mississippi, United States

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St Louis, Missouri, United States

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Lincoln, Nebraska, United States

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Omaha, Nebraska, United States

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Lebanon, New Hampshire, United States

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Camden, New Jersey, United States

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Cherry Hill, New Jersey, United States

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Hackensack, New Jersey, United States

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Haddon Heights, New Jersey, United States

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West Orange, New Jersey, United States

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Brooklyn, New York, United States

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New York, New York, United States

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Poughkeepsie, New York, United States

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Syracuse, New York, United States

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Greensboro, North Carolina, United States

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Pinehurst, North Carolina, United States

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Raleigh, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Cleveland, Ohio, United States

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Columbus, Ohio, United States

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Fairview Park, Ohio, United States

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Marion, Ohio, United States

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Toledo, Ohio, United States

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Midwest City, Oklahoma, United States

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Easton, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Charleston, South Carolina, United States

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Columbia, South Carolina, United States

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Greenville, South Carolina, United States

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Chattanooga, Tennessee, United States

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Knoxville, Tennessee, United States

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Memphis, Tennessee, United States

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Nashville, Tennessee, United States

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Austin, Texas, United States

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Corpus Christi, Texas, United States

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Dallas, Texas, United States

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Fort Worth, Texas, United States

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Houston, Texas, United States

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Odessa, Texas, United States

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Tyler, Texas, United States

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Charlottesville, Virginia, United States

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Norfolk, Virginia, United States

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Richmond, Virginia, United States

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Spokane, Washington, United States

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La Crosse, Wisconsin, United States

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Milwaukee, Wisconsin, United States

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Liverpool, New South Wales, Australia

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New Lambton, New South Wales, Australia

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Bedford Park, South Australia, Australia

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Perth-Western Australia, Australia

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Calgary, Alberta, Canada

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London, Ontario, Canada

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Related Publications (2)

  • Yano Y, Greenland P, Lloyd-Jones DM, Daoud EG, Koehler JL, Ziegler PD. Simulation of Daily Snapshot Rhythm Monitoring to Identify Atrial Fibrillation in Continuously Monitored Patients with Stroke Risk Factors. PLoS One. 2016 Feb 16;11(2):e0148914. doi: 10.1371/journal.pone.0148914. eCollection 2016.

  • Glotzer TV, Daoud EG, Wyse DG, Singer DE, Ezekowitz MD, Hilker C, Miller C, Qi D, Ziegler PD. The relationship between daily atrial tachyarrhythmia burden from implantable device diagnostics and stroke risk: the TRENDS study. Circ Arrhythm Electrophysiol. 2009 Oct;2(5):474-80. doi: 10.1161/CIRCEP.109.849638. Epub 2009 Aug 4.

MeSH Terms

Conditions

Atrial FibrillationStrokeHeart Failure

Interventions

Diagnosis

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and SymptomsCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular Diseases

Study Officials

  • Emile Daoud, MD

    Riverside Hospital

    PRINCIPAL INVESTIGATOR
  • Taya Glotzer, MD

    Hackensack Meridian Health

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

January 18, 2006

First Posted

January 20, 2006

Study Start

November 1, 2003

Primary Completion

June 1, 2007

Study Completion

June 1, 2007

Last Updated

December 11, 2008

Record last verified: 2008-12

Locations