NCT00276354

Brief Summary

The main purpose of this study is to evaluate the tolerance of long term repeated doses of Forlax® 10g versus lactulose in elderly ambulatory or institutionalized patients, paying special attention to digestive and nutritional status.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
246

participants targeted

Target at P75+ for phase_4

Timeline
Completed

Started Dec 1999

Geographic Reach
1 country

146 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 1999

Completed
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

November 20, 2001

Completed
4.1 years until next milestone

First Submitted

Initial submission to the registry

January 12, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

January 13, 2006

Completed
Last Updated

July 26, 2019

Status Verified

July 1, 2019

First QC Date

January 12, 2006

Last Update Submit

July 24, 2019

Conditions

Outcome Measures

Primary Outcomes (5)

  • Clinical and biological tolerance with special attention to digestive and nutritional status. Clinical tolerance will be assessed by digestive symptomatology collected on a daily basis

  • Digestive examination assessed at screening wash-out period and each month

  • Nutritional status assessed at screening wash-out period, month 3 and month 6

  • Vital signs assessed at screening wash-out period, month 3 and month 6. Biological tolerance will be assessed by nutritional markers, malabsorption markers and routine laboratory tests assessed at screening wash-out period and month 3 and 6.

  • Drug interaction assessment assessed at screening wash-out period and month 3 and 6.

Secondary Outcomes (2)

  • Long term efficacy based on daily nurse diary

  • Healthcare cost analysis.

Interventions

Eligibility Criteria

Age70 Years+
Sexall
Healthy VolunteersNo
Age GroupsOlder Adult (65+)

You may qualify if:

  • Institutionalized patients (in a medical care ward) for at least 3 months, or ambulatory patients
  • Suffering from chronic constipation defined as:
  • either less than 3 stools per week for at least 3 months and no or partial efficacy of dietary advices, OR
  • patient has less than 3 stools during 7 consecutive days of the screening wash-out period

You may not qualify if:

  • known organic intestinal disease
  • having had intestinal surgery
  • abdominal or pelvic radiation, carcinoma, obstructive disease, malabsorption disease
  • fecal mass in the rectum which cannot be completely evacuated during the screening wash-out period

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (146)

19 rue Jules Guesde

Abscon, 59215, France

Location

Centre Saint Victor

Amiens, 80054, France

Location

117 ter rue Jean Jaurès

Anzin, 59410, France

Location

8 rue Jean Jaurès

Anzin, 59410, France

Location

26 av. Charles de Gaulle

Aubevoye, 27940, France

Location

89 avenue de Niort

Beauvoir-sur-Niort, 79360, France

Location

11 Place de la République

Blois, 41000, France

Location

39, avenue de France

Blois, 41000, France

Location

30 rue Bayeux

Bretteville-l'Orgueilleuse, 14740, France

Location

30 rue Pasteur

Bruille-lez-Marchiennes, 59490, France

Location

6 avenue du 6 Juin

Caen, 14000, France

Location

98 Boulevard du Maréchal Lyautey

Caen, 14000, France

Location

Rue de l'Hôtel de Ville

Carquefou, 44470, France

Location

La Cerisaie

Castelmaurou, 31180, France

Location

33 rue Gambetta

Château-Renault, 37110, France

Location

94 bis bld de la République

Châtelaillon-Plage, 17340, France

Location

25 avenue de Nantes

Cholet, 49300, France

Location

116 rue Henri Barbusse

Denain, 59220, France

Location

25 Place Gambetta

Denain, 59220, France

Location

6 rue de Ronde

Derval, 44590, France

Location

CHS de la Chartreuse

Dijon, 21000, France

Location

10 rue du Soleil Couchant

Dompierre-sur-Mer, 17139, France

Location

19, avenue de la Gare

Droué, 41270, France

Location

5 route de Paris

Écouis, 27440, France

Location

1 rue du Jardin Botanique

Évreux, 27000, France

Location

6 Centre Commercial les Peupliers

Évreux, 27000, France

Location

8 bis rue du Bout du Pont

Faverolles-sur-Cher, 41400, France

Location

9 rue Cure

Fenioux, 79160, France

Location

15 rue Taffin

Fresnes-sur-Escaut, 59970, France

Location

95 rue Jean-Jaurès

Fresnes-sur-Escaut, 59970, France

Location

14 av. Aristide Briand

Gravigny, 27930, France

Location

CHU Grenoble

Grenoble, 38043, France

Location

Hôpital Charles Foix

Ivry-sur-Seine, 94205, France

Location

Résidence, Grand Maison

L'Union, 31240, France

Location

13 rue Balletant

La Ferté-Imbault, 41300, France

Location

62 rue de Lattre

La Forêt-sur-Sèvre, 79380, France

Location

121 rue M. Delage

La Garde, 83130, France

Location

8 Chemin des Vendéens

La Jubaudière, 49510, France

Location

11 place Sainte Anne

La Riche, 37520, France

Location

194 rue Marius Lacroix

La Rochelle, 17000, France

Location

28 rue du Paradis

La Séguinière, 49280, France

Location

215 route de Bretagne

La Verenne, 44270, France

Location

1, rue de l'Egalité

Lamotte-Beuvron, 41600, France

Location

7 rue de Bel Air

Le Cellier, 44850, France

Location

60 rue de la République

Le Neubourg, 27110, France

Location

Hôpital Saint Julien

Le Petit-Quevilly, 76140, France

Location

Hôpital Saint-Julien

Le Petit-Quevilly, 76140, France

Location

21 Avenue Gabriel Péri

Le Pradet, 83220, France

Location

360 Avenue de la 1ère DFL

Le Pradet, 83220, France

Location

360, avenue de la 1ère DFL

Le Pradet, 83220, France

Location

390 av. de la lère DFL

Le Pradet, 83220, France

Location

46 Place Paul Flamenq

Le Pradet, 83220, France

Location

61 avenue de la lère DFL

Le Pradet, 83220, France

Location

13 rue de la Libération

Les Andelys, 27700, France

Location

Maison de Retrate Saint-Jean

Lille, 59000, France

Location

57 rue Dupont de l'Eure

Louviers, 27400, France

Location

9 rue du Chatel

Louviers, 27400, France

Location

Bd Clémenceau

Louviers, 27400, France

Location

8 rue Saint Venant

Luynes, 37230, France

Location

1 rue Pavée

Mainneville, 27150, France

Location

Centre de Gérontologie, Yvon Lamour

Maniquerville, 76400, France

Location

4 rue de Champagne

Marly, 59770, France

Location

10 rue des Vignes

Ménigoute, 79340, France

Location

94 rue Henri Urbain

Mortagne-du-Nord, 59158, France

Location

25 rue V. Désormeaux

Mûrs-Erigné, 49610, France

Location

181 rue Paul Bellamy

Nantes, 44000, France

Location

101 Boulevard de Doulon

Nantes, 44300, France

Location

63 rue de la Bottière

Nantes, 44300, France

Location

13 av. de la République

Niort, 79000, France

Location

189 Avenue de la Rochelle

Niort, 79000, France

Location

277 av. de la Rochelle

Niort, 79000, France

Location

6 pl. de la Comédie

Niort, 79000, France

Location

24 rue de la Poste

Niort-Souche, 79000, France

Location

30 Boulevard de la Gare

Nort-sur-Erdre, 44390, France

Location

12 place d'Armes

Nueil-sur-Layon, 49560, France

Location

26 Place Pasteur

Onnaing, 59624, France

Location

76 rue des Ormeaux

Oudon, 44521, France

Location

16 rue Aristide Briand

Pacy-sur-Eure, 27120, France

Location

Hôpital Pitié Salpétrière

Paris, 75561, France

Location

Centre Hospitalier Sud Hôpital Xavier Arnozan

Pessac, 33604, France

Location

14 rue de Valencay

Périgny, 17180, France

Location

14 rue de Valençay

Périgny, 17180, France

Location

3 Rue Nouvelle

Pierrefitte-sur-Sauldre, 41300, France

Location

29 rue Blin

Pont-de-l'Arche, 27340, France

Location

35 bis rue du Général de Gaulle

Pont-de-l'Arche, 27340, France

Location

28 bis route de Niort

Prahecq, 79230, France

Location

7 rue Gambetta

Quarouble, 59243, France

Location

271 rue Henri Durre

Raismes, 59590, France

Location

338 rue Henri Durre

Raismes, 59590, France

Location

Hôpital Boisguillaume - CHU de Rouen

Rouen, 76031, France

Location

Hôpital Charles Nicolle - Service de Biochimie Médicale

Rouen, 76031, France

Location

Hôpital Charles Nicolle - Service de Gastroentérologie et Nutrition

Rouen, 76031, France

Location

Centre Hospitalier

Saint-Amand-les-Eaux, 59230, France

Location

30 av. du Gl. de Gaulle

Saint-Avertin, 37550, France

Location

Centre de Long Séjour

Saint-Chamond, 42400, France

Location

Centre Hospitalier St Chamond

Saint-Chamond, 42400, France

Location

5 rue Saint Nicolas

Saint-Germain-de-Marencennes, 17700, France

Location

1 rue Vanneau

Saint-Jean-de-Liversay, 17170, France

Location

Hôpital de Saint Jean de luz

Saint-Jean-de-Luz, 64500, France

Location

34 rue du Poirier

Saint-Macaire-en-Mauges, 49450, France

Location

53 bld du 8 Mai 1945

Saint-Macaire-en-Mauges, 49450, France

Location

Les jardins de Rambam

Saint-Orens-de-Gameville, 31650, France

Location

Maison de retraite

Saint-Orens-de-Gameville, 31650, France

Location

36 Rue Louise Michel

Saint-Ouen, 41100, France

Location

Chemin Vert

Saint-Pierre-des-Échaubrognes, 79700, France

Location

Rue du Petit Montrevault

Saint-Pierre-Montlimart, 49110, France

Location

Chemin de la Choisière

Saint-Rémy-en-Mauges, 49110, France

Location

27 rue Principale

Saint-Romain-sur-Cher, 41140, France

Location

12, rue Jean Cocteau

Saint-Saulve, 59880, France

Location

1 Allée Jean Restout

Saint-Sébastien-de-Morsent, 27180, France

Location

19 rue de la Mairie

Saint-Vincent-des-Landes, 44590, France

Location

116 bis rue du 14 Juillet

Sainte-Marie-de-Ré, 17740, France

Location

31 bis rue de la République

Sainte-Marie-de-Ré, 17740, France

Location

Les Vergers du Château

Solliès-Pont, 83210, France

Location

31 bis rue de la République

Ste Marie En Ré, 17740, France

Location

28 rue Roger Salengro

Thiant, 59224, France

Location

18 rue de la Baronne

Thilouze, 37260, France

Location

1 rue de Bayeux

Tilly-sur-Seulles, 14250, France

Location

121 av. de la Résistance

Toulon, 83000, France

Location

148 Avenue Cuzin

Toulon, 83000, France

Location

355 Avenue Claret

Toulon, 83000, France

Location

535 av. de la Résistance

Toulon, 83000, France

Location

6 bld Noble le Piermone

Toulon, 83000, France

Location

641 rue Sainte Claire Deville

Toulon, 83000, France

Location

641 rue Sainte Deville

Toulon, 83000, France

Location

15 rue Gimelli

Toulon, 83100, France

Location

112 Avenue du Xvème corps

Toulon, 83200, France

Location

2 pl. Martin Bidouré

Toulon, 83200, France

Location

4 pl. Jean Macé

Toulon, 83200, France

Location

Capitole Santé

Toulouse, 31000, France

Location

Hostellerie Languedocienne

Toulouse, 31000, France

Location

Hôpital de la Grave-Casse Lardit

Toulouse, 31052, France

Location

Résidence St Simon

Toulouse, 31500, France

Location

3 rue Maryse Bastié

Tours, 37000, France

Location

81 rue Blaise Pascal

Tours, 37000, France

Location

13 rue Ernest Huard

Tours, 37100, France

Location

Centre de Gériatrie du Comte Henry

Troyes, 10000, France

Location

Centre Hospitalier de Troyes

Troyes, 10000, France

Location

9 rue Beaurepaire

Valanjou, 49670, France

Location

16 rue Anatole France

Valenciennes, 59300, France

Location

Résidence Saly - 2 rue S. Lebourg

Valenciennes, 59300, France

Location

200 rue Jean Jaurès

Vieux-Condé, 59690, France

Location

4 rue Beaurepaire

Vihiers, 49310, France

Location

Hôpital Paul Brousse

Villejuif, 94804, France

Location

4, Place Jules Verne

Vineuil, 41350, France

Location

85 rue Jean Jaurès

Wallers, 59135, France

Location

MeSH Terms

Conditions

Constipation

Interventions

Polyethylene Glycols

Condition Hierarchy (Ancestors)

Signs and Symptoms, DigestiveSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Ethylene GlycolsGlycolsAlcoholsOrganic ChemicalsPolymersMacromolecular SubstancesBiomedical and Dental MaterialsManufactured MaterialsTechnology, Industry, and Agriculture

Study Officials

  • Ipsen Medical Director

    Ipsen

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
SINGLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 12, 2006

First Posted

January 13, 2006

Study Start

December 1, 1999

Study Completion

November 20, 2001

Last Updated

July 26, 2019

Record last verified: 2019-07

Locations