Iron Supplementation in Schistosomiasis and Soil Transmitted Helminths Control Programmes in Zambia

NCT00276224 | Completed

• 1 other identifier: SRP-ZM-VM-04
• Study Type: interventional
• Target: 480
• Locations: 1 country
• Sites: 1

Brief Summary

The objectives of this study is:

• to establish the coverage rate of weekly iron supplementation in children in intervention schools over a period of nine months
• document any side effects of weeekly iron supplementation among children in intervention schools over a period of nine months asses the feasibility of incorporating the weekly iron supplementation programme into the normal school activity in intervention schools determine the extent of acceptability and support for the iron supplementation programme by staff at the health centre nearest to the intervention schools
• compare the praziquantel efficacy and schistosomiasis reinfection in children in intervention schools with that of children in control schools following the introduction of weekely iron supplementation over a period of nine months
• determine the impact of weekly iron supplementation on haemoglobin levels of children in intervention schools and compare with children in control schools over a period of nine months

Conditions

Schistosomiasis; Helminthiases; Anaemia

Keywords

iron deficiency schistosomiasis soil transmitted helminths

Outcome Measures

Primary Outcomes (3)

• Urine samples examined for schistsoma haematobium at month 0, 3. 6 and 9

• Stool samples examined for schistsoma mansoni at mont 0, 3, 6 and 9

• Blood samples examined for haemoglobin level mont 0 and month 9

Secondary Outcomes (8)

• Any side effects to iron supplementation, measured every week for the first foru weeks after treatment start. Mesured on:

• - headache

• nausea

• vomiting

• body weakness

Interventions

ferrous sulphate (drug) DRUG

Eligibility Criteria

• Age: 9 Years - 15 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

Sponsors & Collaborators

• DBL -Institute for Health Research and Development: lead

Study Sites (1)

Kenani and Chandwe School

Kenani, Nchelenge district, Zambia

Location

Related Publications (1)

• Mwanakasale V, Siziya S, Mwansa J, Koukounari A, Fenwick A. Impact of iron supplementation on schistosomiasis control in Zambian school children in a highly endemic area. Malawi Med J. 2009 Mar;21(1):12-8. doi: 10.4314/mmj.v21i1.10982.

  PMID: 19780472 DERIVED

MeSH Terms

Conditions

Schistosomiasis; Helminthiasis; Anemia

Interventions

ferrous sulfate; Pharmaceutical Preparations

Condition Hierarchy (Ancestors)

Trematode Infections; Parasitic Diseases; Infections; Vector Borne Diseases; Hematologic Diseases; Hemic and Lymphatic Diseases

Study Officials

• Victor Mwanakasale, Ph.d.,M.Sc.

  Tropical Disease Research Centre, Ndola, Zambia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 12, 2006
• First Posted: January 13, 2006
• Study Start: September 1, 2005
• Study Completion: April 1, 2006
• Last Updated: October 31, 2007

Record last verified: 2007-10

Locations

ZA (1)