NCT03187366

Brief Summary

Schistosomiasis is a flatworm transmitted from freshwater snails to humans in the tropics. In addition to this infectious disease, tropical developing countries are faced with malnutrition. We propose to alter pesticide and compost use to reduce schistosomiasis and maintain or even improve crop production.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
1,477

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2017

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 2, 2017

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

June 12, 2017

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 14, 2017

Completed
8.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2025

Completed
Last Updated

March 22, 2023

Status Verified

March 1, 2023

Enrollment Period

8.7 years

First QC Date

June 12, 2017

Last Update Submit

March 21, 2023

Conditions

Schistosomiasis

Outcome Measures

Primary Outcomes (1)

  • Schistosomiasis reinfection rate

    Schistosomiasis reinfection rate

    One year

Secondary Outcomes (1)

  • Crop yields

    One year

Study Arms (3)

Status quo

NO INTERVENTION

Status quo pesticide use

Low risk

ACTIVE COMPARATOR

Villages shifted to low risk pesticides that don't kill prawns

Other: Bottom-up intervention

No agrochemicals

EXPERIMENTAL

Villages that eliminate agrochemicals

Other: Bottom-up intervention

Interventions

Bottom-up interventionOTHER

Some interventions are bottom-up, where we manipulate the resources of snails and some are top-down, where we manipulate the predators of snails.

Also known as: Top-down intervention
Low riskNo agrochemicals

Eligibility Criteria

Age5 Years - 17 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • School age children

You may not qualify if:

  • Non-school age children

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Espoir Pour La Santé (EPLS)

Saint-Louis, Senegal

Location

Related Publications (1)

  • Rohr JR, Sack A, Bakhoum S, Barrett CB, Lopez-Carr D, Chamberlin AJ, Civitello DJ, Diatta C, Doruska MJ, De Leo GA, Haggerty CJE, Jones IJ, Jouanard N, Lund AJ, Ly AT, Ndione RA, Remais JV, Riveau G, Schacht AM, Seck M, Senghor S, Sokolow SH, Wolfe C. A planetary health innovation for disease, food and water challenges in Africa. Nature. 2023 Jul;619(7971):782-787. doi: 10.1038/s41586-023-06313-z. Epub 2023 Jul 12.

    PMID: 37438520DERIVED

MeSH Terms

Conditions

Schistosomiasis

Condition Hierarchy (Ancestors)

Trematode InfectionsHelminthiasisParasitic DiseasesInfectionsVector Borne Diseases

Study Officials

  • Jason R Rohr, PhD

    University of South Florida, Department of Integrative Biology

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 12, 2017

First Posted

June 14, 2017

Study Start

January 2, 2017

Primary Completion

September 1, 2025

Study Completion

September 1, 2025

Last Updated

March 22, 2023

Record last verified: 2023-03

Locations

SE(1)