NCT00267124

Brief Summary

The purpose of this study is to determine the effects of exercise and cardiorespiratory fitness on age-related brain changes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
172

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Nov 2004

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2004

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

December 16, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

December 20, 2005

Completed
3.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2009

Completed
Last Updated

April 6, 2017

Status Verified

April 1, 2017

Enrollment Period

4.8 years

First QC Date

December 16, 2005

Last Update Submit

April 4, 2017

Conditions

Alzheimer's Disease

Keywords

cognitive declinedementianeuroimaging

Study Arms (2)

1

elderly people who have normal cognition

2

elderly people who have mild to moderate Alzheimer's disease

Eligibility Criteria

Age65 Years+
Sexall
Healthy VolunteersYes
Age GroupsOlder Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

KU memory clinic patients, volunteers from the community, and the states of Kansas and Missouri

You may qualify if:

  • Age 65 years or older
  • Healthy male or female
  • Normal control volunteers and early Alzheimer's disease patients
  • Clinical Dementia Rating of 0, 0.5, or 1.0
  • On stable doses of medications

You may not qualify if:

  • Unstable angina
  • Schizophrenia
  • Clinical signs of depression; major depression; mental health disorder; nervous system disorder
  • Significant visual/auditory impairment
  • Significant system illness; cancer
  • Pacemaker/metal
  • Thyroid problems
  • Kidney dialysis
  • Organ transplant
  • Alcoholism
  • Heart surgery
  • Insulin

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Kansas Medical Center

Kansas City, Kansas, 66160, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples are collected analyzed and banked as whole blood, serum, white blood cells

MeSH Terms

Conditions

Alzheimer DiseaseCognitive DysfunctionDementia

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesTauopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental DisordersCognition Disorders

Study Officials

  • Jeffrey Burns, MD

    University of Kansas Medical Center, Landon Center on Aging

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 16, 2005

First Posted

December 20, 2005

Study Start

November 1, 2004

Primary Completion

August 1, 2009

Study Completion

August 1, 2009

Last Updated

April 6, 2017

Record last verified: 2017-04

Locations

US(1)