Early Markers of Alzheimer's Disease: Structural and Functional Brain Changes

NCT01867372 | Terminated

• 2 other identifiers: 99990332803-AG-N328
• Study Type: observational
• Target: 213
• Locations: 1 country
• Sites: 3

Brief Summary

Background: \- Participants in the Baltimore Longitudinal Study of Aging are being studied to examine changes in brain structure and function over time, and to determine if these changes can predict the likelihood that an individual will develop thinking and memory impairments such as Alzheimer s disease later in life. Imaging studies and neuropsychological testing have been conducted on current participants, and new participants are being recruited to the study. To develop better treatments and therapies for aging-related memory loss and other disorders, researchers are interested in determining whether early prediction of thinking and memory impairments are accurate and in evaluating factors that affect these predictions. Objectives: \- To use imaging studies and tests of thinking and memory to determine early markers of Alzheimer s disease and other cognitive impairments. Eligibility: \- Current participants and new recruits to the Baltimore Longitudinal Study of Aging. Design:

• Participants will be screened with a full medical history and physical examination, as well as blood and urine tests.
• Participants will have testing visits as directed by the study researchers. All participants will have tests as part of their an initial enrollment in the study, and may be asked to return yearly, 2 years later, or 4 years later for repeated tests.
• At each visit, participants will have brain imaging scans (including magnetic resonance imaging and/or magnetic resonance spectroscopy to measure brain structure and function, and positron emission tomography to study blood flow in the brain) to evaluate brain structure and function. Participants will also take tests of memory and problem-solving skills.
• Treatment will not be provided as part of this protocol.

Conditions

Alzheimer's Disease

Keywords

Alzheimer's Disease

Outcome Measures

Primary Outcomes (2)

• Accelerated preclinical changes in brain structure and function in specific regions will predict which individuals develop cognitive impairment and Alzheimer s disease

  Ongoing

• Changes in brain structure are predictors of cognitive decline and impairment though neuroimaging assessments

  Ongoing

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• Miscellaneous: Body weight \> 300 pounds, history of significant radiation exposure.
• Participants with pacemakers, implanted electronic hearing devices, aneurysm clips, shrapnel, unallowed prosthetic or any other metallic device in their bodies.
• Pre-existing CNS disease or severe cardiovascular disease (MI, CABG, angioplasty).

Sponsors & Collaborators

• National Institute on Aging (NIA): lead
• Johns Hopkins University: collaborator

Study Sites (3)

Johns Hopkins University

Baltimore, Maryland, 21205, United States

Location

Kennedy Krieger Institute

Baltimore, Maryland, 21205, United States

Location

National Institute of Aging, Clinical Research Unit

Baltimore, Maryland, 21224, United States

Location

MeSH Terms

Conditions

Alzheimer Disease

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Susan M Resnick, Ph.D.

  National Institute on Aging (NIA)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: OTHER
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 30, 2013
• First Posted: June 4, 2013
• Study Start: March 10, 2003
• Primary Completion: September 22, 2014
• Study Completion: September 22, 2014
• Last Updated: December 12, 2019

Record last verified: 2014-09-22

Locations

US (3)