NCT01867346

Brief Summary

Background: \- The Baltimore Longitudinal Study of Aging (BLSA) is a long-term study of human aging. To see how the brain changes with age, researchers will study BLSA participants who are at least 60 years old. In particular, researchers are looking for early markers of possible Alzheimer's disease and other conditions that cause memory loss. To do so, they will give tests of memory and brain function, and stay in close contact with participants. Objectives: \- To study cognitive changes that occur in normal aging and in people who develop memory problems. Eligibility: \- Individuals at least 60 years of age who are participating in the BLSA. Design:

  • There are three parts to this study. These study procedures will be done under the usual BLSA guidelines.
  • Participants will take paper and pencil tests. The tests measure skills such as language, attention, memory, and problem solving. They will also ask questions about emotions and feelings.
  • Participants will give the name and phone number of a person who knows them well and sees them often. Researchers will ask this person to fill out questionnaires on the effects of aging on the participant. These questions will monitor the participant's memory and ability to function independently.
  • Participants will have regular phone calls between study visits. These calls will help to keep their information up to date.
  • Participants will continue on this study for as long as they are able to participate.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,850

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Mar 2003

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 19, 2003

Completed
10.2 years until next milestone

First Submitted

Initial submission to the registry

May 29, 2013

Completed
6 days until next milestone

First Posted

Study publicly available on registry

June 4, 2013

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 16, 2014

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 2, 2015

Completed
Last Updated

April 5, 2018

Status Verified

January 2, 2015

Enrollment Period

11.3 years

First QC Date

May 29, 2013

Last Update Submit

April 4, 2018

Conditions

Alzheimer's Disease

Keywords

CognitionAgingCognitive DeclineDementiaAlzheimer's Disease

Outcome Measures

Primary Outcomes (3)

  • Identifying early makers of cognitive and Alzheimer s disease

    Ongoing

  • Characterizing risk factors which modify progression to these states

    Ongoing

  • Cognitive changes associated with other health factors

    Ongoing

Eligibility Criteria

Age60 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • All BLSA participants 60 years of age and older are included and will receive cognitive evaluations on their BLSA visits.

You may not qualify if:

  • Participants who are younger than 60 years old are excluded. Specialized testing procedures are adopted in the case of hearing or visual impairments

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Institute of Aging, Clinical Research Unit

Baltimore, Maryland, 21224, United States

Location

Related Publications (3)

  • Lindeman RD, Tobin JD, Shock NW. Association between blood pressure and the rate of decline in renal function with age. Kidney Int. 1984 Dec;26(6):861-8. doi: 10.1038/ki.1984.229.

    PMID: 6533397BACKGROUND

  • Zonderman AB, Giambra LM, Arenberg D, Resnick SM, Costa PT Jr, Kawas CH. Changes in immediate visual memory predict cognitive impairment. Arch Clin Neuropsychol. 1995 Mar;10(2):111-23.

    PMID: 14589733BACKGROUND

  • Troncoso JC, Martin LJ, Dal Forno G, Kawas CH. Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging. Neurobiol Aging. 1996 May-Jun;17(3):365-71. doi: 10.1016/0197-4580(96)00028-0.

    PMID: 8725897BACKGROUND

MeSH Terms

Conditions

Alzheimer DiseaseCognitive DysfunctionDementia

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesTauopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental DisordersCognition Disorders

Study Officials

  • Alan B Zonderman, Ph.D.

    National Institute on Aging (NIA)

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Time Perspective
PROSPECTIVE
Sponsor Type
NIH
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 29, 2013

First Posted

June 4, 2013

Study Start

March 19, 2003

Primary Completion

June 16, 2014

Study Completion

January 2, 2015

Last Updated

April 5, 2018

Record last verified: 2015-01-02

Locations

US(1)