Study Stopped
Study drug no longer available resulting in lack of study drug for participants.
Cisplatin and Radiation Therapy With or Without Tirapazamine in Treating Patients With Cervical Cancer
A Phase III, Randomized Trial of Weekly Cisplatin and Radiation Versus Cisplatin and Tirapazamine and Radiation in Stage IB2, IIA, IIIB and IVA Cervical Carcinoma Limited to the Pelvis
5 other identifiers
interventional
402
2 countries
282
Brief Summary
This randomized phase III trial is studying cisplatin, radiation therapy, and tirapazamine to see how well they work compared to cisplatin and radiation therapy in treating patients with cervical cancer. Drugs used in chemotherapy, such as cisplatin and tirapazamine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Internal radiation uses radioactive material placed directly into or near a tumor to kill tumor cells. Cisplatin and tirapazamine may make tumor cells more sensitive to radiation therapy. It is not yet known whether giving cisplatin together with radiation therapy is more effective with or without tirapazamine in treating cervical cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_3
Started Feb 2006
Typical duration for phase_3
282 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 6, 2005
CompletedFirst Posted
Study publicly available on registry
December 7, 2005
CompletedStudy Start
First participant enrolled
February 1, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2010
CompletedResults Posted
Study results publicly available
July 2, 2017
CompletedJuly 23, 2019
July 1, 2019
4.5 years
December 6, 2005
October 9, 2015
July 19, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Progression-free Survival - Percentage of Patients Alive and Progression Free
Patients' progression status based on clinical, radiological or pathological (histological) evidence of disease after study therapy. Progression includes any death without evidence of disease progression. Progression-free Survival (PFS) is defined as time in month from study enrollment to disease progression, death or date of last contact.
From study entry until first disease progression, death or date of last contact, up to 6 years
Secondary Outcomes (2)
Overall Survival
From study entry to death or last contact, up to 6 years
Adverse Events (Grade 3 or Higher) During Treatment Period
All Adverse Events (AEs) occuring during treatment and up to 30 days after stopping the study treatment are reported
Study Arms (2)
Arm I (cisplatin)
ACTIVE COMPARATORPatients receive cisplatin IV on days 1, 8, 15, 22, 29, and 36 (weeks 1-6).
Arm II (cisplatin, tirapazamine)
EXPERIMENTALPatients receive tirapazamine IV over 2 hours on days 1, 8, 10, 12, 15, 22, 24, 26, and 29 and cisplatin IV over 1 hour on days 1, 15, and 29.
Interventions
Given IV
Eligibility Criteria
You may qualify if:
- Histologically confirmed invasive squamous cell carcinoma, adenocarcinoma, or adenosquamous cell carcinoma of the uterine cervix
- Stage IB2, IIA, IIB, IIIB, or IVA disease
- Stage IIA tumors must be \> 4 cm
- Primary, untreated disease
- Negative, non-suspicious para-aortic nodes by lymphangiogram, CT scan, MRI, or lymphadenectomy
- Must have been adequately clinically staged
- Suitable for treatment with radical intent using concurrent chemotherapy and pelvic radiotherapy
- No disease involvement of the lower third of the vagina regardless of stage (all stage IIIA, IIIB and IVA with lower one-third involvement)
- No carcinoma of the cervical stump
- Performance status - GOG 0-3
- Absolute neutrophil count ≥ 1,500/mm\^3
- Platelet count ≥ 100,000/mm\^3
- Bilirubin ≤ 1.5 times upper limit of normal (ULN)
- SGOT ≤ 3 times ULN
- Alkaline phosphatase ≤ 3 times ULN
- +15 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- National Cancer Institute (NCI)lead
- NCIC Clinical Trials Groupcollaborator
- Gynecologic Oncology Groupcollaborator
Study Sites (282)
University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
Mobile Infirmary Medical Center
Mobile, Alabama, 36607, United States
Providence Alaska Medical Center
Anchorage, Alaska, 99508, United States
Banner Good Samaritan Medical Center
Phoenix, Arizona, 85006, United States
Western Regional CCOP
Phoenix, Arizona, 85006, United States
Highlands Oncology Group PA - Fayetteville
Fayetteville, Arkansas, 72703, United States
Washington Regional Medical Center - Fayetteville
Fayetteville, Arkansas, 72703, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
East Bay Radiation Oncology Center
Castro Valley, California, 94546, United States
City of Hope Medical Center
Duarte, California, 91010, United States
Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095, United States
Bay Area Tumor Institute CCOP
Oakland, California, 94609, United States
University of California Medical Center At Irvine-Orange Campus
Orange, California, 92868, United States
Pomona Valley Hospital Medical Center
Pomona, California, 91767, United States
Stanford University Hospitals and Clinics
Stanford, California, 94305, United States
Olive View-University of California Los Angeles Medical Center
Sylmar, California, 91342, United States
Colorado Gynecologic Oncology Group
Aurora, Colorado, 80010, United States
Memorial Hospital Colorado Springs
Colorado Springs, Colorado, 80909, United States
North Colorado Medical Center
Greeley, Colorado, 80631, United States
McKee Medical Center
Loveland, Colorado, 80539, United States
Hartford Hospital
Hartford, Connecticut, 06102, United States
The Hospital of Central Connecticut
New Britain, Connecticut, 06050, United States
Yale University
New Haven, Connecticut, 06520, United States
Beebe Medical Center
Lewes, Delaware, 19958, United States
Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718, United States
Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
Florida Gynecologic Oncology
Fort Myers, Florida, 33905, United States
Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980, United States
UF Cancer Center at Orlando Health
Orlando, Florida, 32806, United States
Piedmont Hospital
Atlanta, Georgia, 30309, United States
Northside Hospital
Atlanta, Georgia, 30342, United States
Saint Joseph's Hospital of Atlanta
Atlanta, Georgia, 30342, United States
Georgia Regents University
Augusta, Georgia, 30912, United States
John B Amos Cancer Center
Columbus, Georgia, 31904, United States
Dekalb Medical Center
Decatur, Georgia, 30033, United States
Wellstar Kennestone Hospital
Marietta, Georgia, 30060, United States
Memorial Health University Medical Center
Savannah, Georgia, 31403, United States
Hawaii Minority Based CCOP
Honolulu, Hawaii, 96813, United States
Queen's Medical Center
Honolulu, Hawaii, 96813, United States
Straub Clinic and Hospital
Honolulu, Hawaii, 96813, United States
University of Hawaii
Honolulu, Hawaii, 96813, United States
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii, 96817, United States
Tripler Army Medical Center
Honolulu, Hawaii, 96859, United States
Maui Memorial Medical Center
Wailuku, Hawaii, 96793, United States
Pali Momi Medical Center
‘Aiea, Hawaii, 96701, United States
Rush - Copley Medical Center
Aurora, Illinois, 60504, United States
Saint Joseph Medical Center
Bloomington, Illinois, 61701, United States
Graham Hospital Association
Canton, Illinois, 61520, United States
Rush University Medical Center
Chicago, Illinois, 60612, United States
University of Illinois
Chicago, Illinois, 60612, United States
University of Chicago
Chicago, Illinois, 60637, United States
Saint Francis Hospital
Evanston, Illinois, 60202, United States
Western Illinois Cancer Treatment Center
Galesburg, Illinois, 61401, United States
Joliet Oncology-Hematology Associates Limited
Joliet, Illinois, 60435, United States
Bromenn Regional Medical Center
Normal, Illinois, 61761, United States
Community Cancer Center Foundation
Normal, Illinois, 61761, United States
Advocate Lutheran General Hospital.
Park Ridge, Illinois, 60068, United States
Illinois CancerCare-Peoria
Peoria, Illinois, 61615, United States
OSF Saint Francis Medical Center
Peoria, Illinois, 61637, United States
Valley Radiation Oncology
Peru, Illinois, 61354, United States
Saint Margaret's Hospital
Spring Valley, Illinois, 61362, United States
Memorial Medical Center
Springfield, Illinois, 62781-0001, United States
Carle Cancer Center
Urbana, Illinois, 61801, United States
Carle Clinic-Urbana Main
Urbana, Illinois, 61801, United States
Elkhart General Hospital
Elkhart, Indiana, 46515, United States
Indiana University Medical Center
Indianapolis, Indiana, 46202, United States
Gynecologic Oncology of Indiana
Indianapolis, Indiana, 46237, United States
Community Howard Regional Health
Kokomo, Indiana, 46904, United States
IU Health La Porte Hospital
La Porte, Indiana, 46350, United States
Franciscan Saint Anthony Health-Michigan City
Michigan City, Indiana, 46360, United States
Saint Joseph Regional Medical Center-Mishawaka
Mishawaka, Indiana, 46545-1470, United States
Memorial Hospital of South Bend
South Bend, Indiana, 46601, United States
Northern Indiana Cancer Research Consortium
South Bend, Indiana, 46628, United States
McFarland Clinic PC-William R Bliss Cancer Center
Ames, Iowa, 50010, United States
Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa, 50325, United States
Mercy Capitol
Des Moines, Iowa, 50307, United States
Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
Iowa Oncology Research Association CCOP
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates-Laurel
Des Moines, Iowa, 50314, United States
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314, United States
Iowa Lutheran Hospital
Des Moines, Iowa, 50316, United States
University of Iowa Hospitals and Clinics
Iowa City, Iowa, 52242, United States
Siouxland Hematology Oncology Associates
Sioux City, Iowa, 51101, United States
Hospital District Sixth of Harper County
Anthony, Kansas, 67003, United States
Cancer Center of Kansas - Chanute
Chanute, Kansas, 66720, United States
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, 67801, United States
Cancer Center of Kansas - El Dorado
El Dorado, Kansas, 67042, United States
Cancer Center of Kansas - Fort Scott
Fort Scott, Kansas, 66701, United States
Cancer Center of Kansas-Independence
Independence, Kansas, 67301, United States
Providence Medical Center
Kansas City, Kansas, 66112, United States
University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
Cancer Center of Kansas-Kingman
Kingman, Kansas, 67068, United States
Lawrence Memorial Hospital
Lawrence, Kansas, 66044, United States
Cancer Center of Kansas - Newton
Newton, Kansas, 67114, United States
Radiation Oncology Practice Corporation Southwest
Overland Park, Kansas, 66210, United States
Cancer Center of Kansas - Parsons
Parsons, Kansas, 67357, United States
Cancer Center of Kansas - Pratt
Pratt, Kansas, 67124, United States
Cancer Center of Kansas - Salina
Salina, Kansas, 67401, United States
Cancer Center of Kansas - Wellington
Wellington, Kansas, 67152, United States
Associates In Womens Health
Wichita, Kansas, 67208, United States
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas, 67208, United States
Cancer Center of Kansas - Main Office
Wichita, Kansas, 67214, United States
Via Christi Regional Medical Center
Wichita, Kansas, 67214, United States
Wesley Medical Center
Wichita, Kansas, 67214, United States
Wichita CCOP
Wichita, Kansas, 67214, United States
Cancer Center of Kansas - Winfield
Winfield, Kansas, 67156, United States
Saint Elizabeth Medical Center South
Edgewood, Kentucky, 41017, United States
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, 40202, United States
Tulane University Health Sciences Center
New Orleans, Louisiana, 70112, United States
Louisiana State University Health Sciences Center Shreveport
Shreveport, Louisiana, 71130, United States
Eastern Maine Medical Center
Bangor, Maine, 04401, United States
Maine Medical Center-Bramhall Campus
Portland, Maine, 04102, United States
Union Hospital of Cecil County
Elkton, Maryland, 21921, United States
University of Massachusetts Medical School
Worcester, Massachusetts, 01655, United States
Bronson Battle Creek
Battle Creek, Michigan, 49017, United States
Spectrum Health Big Rapids Hospital
Big Rapids, Michigan, 49307, United States
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
Green Bay Oncology - Escanaba
Escanaba, Michigan, 49431, United States
Grand Rapids Clinical Oncology Program
Grand Rapids, Michigan, 49503, United States
Mercy Health Saint Mary's
Grand Rapids, Michigan, 49503, United States
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan, 49503, United States
Spectrum Health-Blodgett Campus
Grand Rapids, Michigan, 49506, United States
Gynecologic Oncology of West Michigan PLLC
Grand Rapids, Michigan, 49546, United States
Green Bay Oncology - Iron Mountain
Iron Mountain, Michigan, 49801, United States
Mercy Health Partners-Hackley Campus
Muskegon, Michigan, 49442, United States
Mercy Health Mercy Campus
Muskegon, Michigan, 49444, United States
William Beaumont Hospital-Royal Oak
Royal Oak, Michigan, 48073, United States
Lakeland Hospital
Saint Joseph, Michigan, 49085, United States
Providence Hospital
Southfield, Michigan, 48075, United States
Munson Medical Center
Traverse City, Michigan, 49684, United States
Metro Health Hospital
Wyoming, Michigan, 49519, United States
Mayo Clinic
Rochester, Minnesota, 55905, United States
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379, United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
University of Missouri - Ellis Fischel
Columbia, Missouri, 65212, United States
Centerpoint Medical Center LLC
Independence, Missouri, 64057, United States
Radiation Oncology Practice Corporation South
Kansas City, Missouri, 64114, United States
Radiation Oncology Practice Corporation - North
Kansas City, Missouri, 64154, United States
Mercy Hospital Springfield
Springfield, Missouri, 65804, United States
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield
Springfield, Missouri, 65804, United States
CoxHealth South Hospital
Springfield, Missouri, 65807, United States
Saint Louis University Hospital
St Louis, Missouri, 63110, United States
Missouri Baptist Medical Center
St Louis, Missouri, 63131, United States
Center for Cancer Care and Research
St Louis, Missouri, 63141, United States
Saint John's Mercy Medical Center
St Louis, Missouri, 63141, United States
Montana Cancer Consortium CCOP
Billings, Montana, 59101, United States
Northern Rockies Radiation Oncology Center
Billings, Montana, 59101, United States
Hematology-Oncology Centers of the Northern Rockies PC
Billings, Montana, 59102, United States
Billings Clinic
Billings, Montana, 59107-7000, United States
Berdeaux, Donald MD (UIA Investigator)
Great Falls, Montana, 59405, United States
Great Falls Clinic
Great Falls, Montana, 59405, United States
Good Samaritan Hospital
Kearney, Nebraska, 68847, United States
Nebraska Methodist Hospital
Omaha, Nebraska, 68114, United States
University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
Center of Hope at Renown Medical Center
Reno, Nevada, 89502, United States
Renown Regional Medical Center
Reno, Nevada, 89502, United States
Cooper Hospital University Medical Center
Camden, New Jersey, 08103, United States
Mountainside Hospital
Montclair, New Jersey, 07042, United States
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County
Mount Holly, New Jersey, 08060, United States
Jersey Shore Medical Center
Neptune City, New Jersey, 07753, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903, United States
UMDNJ - New Jersey Medical School
Newark, New Jersey, 07103, United States
Community Medical Center
Toms River, New Jersey, 08755, United States
Virtua West Jersey Hospital Voorhees
Voorhees Township, New Jersey, 08043, United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106, United States
Women's Cancer Care Associates LLC
Albany, New York, 12208, United States
Island Gynecologic Oncology
Brightwaters, New York, 11718, United States
State University of New York Downstate Medical Center
Brooklyn, New York, 11203, United States
Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
Queens Hospital Center
Jamaica, New York, 11432, United States
North Shore University Hospital
Manhasset, New York, 11030, United States
North Shore-LIJ Health System CCOP
Manhasset, New York, 11030, United States
Orange Regional Medical Center
Middletown, New York, 10940, United States
Long Island Jewish Medical Center
New Hyde Park, New York, 11040, United States
North Shore-LIJ Health System/Center for Advanced Medicine
New Hyde Park, New York, 11040, United States
New York University Langone Medical Center
New York, New York, 10016, United States
Memorial Sloan-Kettering Cancer Center
New York, New York, 10065, United States
Stony Brook University Medical Center
Stony Brook, New York, 11794, United States
State University of New York Upstate Medical University
Syracuse, New York, 13210, United States
Montefiore Medical Center-Weiler Division
The Bronx, New York, 10461, United States
Good Samaritan Hospital Medical Center
West Islip, New York, 11795, United States
Hope Women's Cancer Centers-Asheville
Asheville, North Carolina, 28816, United States
University of North Carolina
Chapel Hill, North Carolina, 27599, United States
Duke University Medical Center
Durham, North Carolina, 27710, United States
New Hanover Regional Medical Center
Wilmington, North Carolina, 28401, United States
Wilson Medical Center
Wilson, North Carolina, 27893, United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
Bismarck Cancer Center
Bismarck, North Dakota, 58501, United States
Mid Dakota Clinic
Bismarck, North Dakota, 58501, United States
Saint Alexius Medical Center
Bismarck, North Dakota, 58501, United States
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501, United States
Akron General Medical Center
Akron, Ohio, 44307, United States
Aultman Health Foundation
Canton, Ohio, 44710, United States
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, 45220, United States
Bethesda North Hospital
Cincinnati, Ohio, 45242, United States
University of Cincinnati
Cincinnati, Ohio, 45267, United States
Case Western Reserve University
Cleveland, Ohio, 44106, United States
MetroHealth Medical Center
Cleveland, Ohio, 44109, United States
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
Columbus, Ohio, 43210, United States
Riverside Methodist Hospital
Columbus, Ohio, 43214, United States
Mount Carmel Health Center West
Columbus, Ohio, 43222, United States
Good Samaritan Hospital - Dayton
Dayton, Ohio, 45406, United States
Miami Valley Hospital
Dayton, Ohio, 45409, United States
Samaritan North Health Center
Dayton, Ohio, 45415, United States
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, 44124, United States
Lake University Ireland Cancer Center
Mentor, Ohio, 44060, United States
Wright-Patterson Medical Center
Wright-Patterson Air Force Base, Ohio, 45433-5529, United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
Cancer Care Associates-Midtown
Tulsa, Oklahoma, 74104, United States
Tulsa Cancer Institute
Tulsa, Oklahoma, 74146, United States
Salem Hospital
Salem, Oregon, 97301, United States
Abington Memorial Hospital
Abington, Pennsylvania, 19001, United States
Lehigh Valley Hospital
Allentown, Pennsylvania, 18105, United States
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem, Pennsylvania, 18015, United States
Lancaster General Hospital
Lancaster, Pennsylvania, 17604, United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
Magee-Womens Hospital of UPMC
Pittsburgh, Pennsylvania, 15213, United States
Western Pennsylvania Hospital
Pittsburgh, Pennsylvania, 15224-1791, United States
Mercy Hospital
Scranton, Pennsylvania, 18501, United States
Hematology and Oncology Associates of North East Pennsylvania
Scranton, Pennsylvania, 18508, United States
Scranton Hematology Oncology
Scranton, Pennsylvania, 18510, United States
Reading Hospital
West Reading, Pennsylvania, 19611, United States
Women and Infants Hospital
Providence, Rhode Island, 02905, United States
Medical University of South Carolina
Charleston, South Carolina, 29425, United States
Black Hills Obstetrics and Gynecology
Rapid City, South Dakota, 57701, United States
Chattanooga Gynecological Oncology
Chattanooga, Tennessee, 37403, United States
Chattanooga's Program in Women's Oncology
Chattanooga, Tennessee, 37403, United States
East Tennessee State University
Johnson City, Tennessee, 37614-0054, United States
Meharry Medical College
Nashville, Tennessee, 37208-3599, United States
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232, United States
The Don and Sybil Harrington Cancer Center
Amarillo, Texas, 79106, United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234, United States
University of Texas Medical Branch at Galveston
Galveston, Texas, 77555-0565, United States
M D Anderson Cancer Center
Houston, Texas, 77030, United States
Doctor's Hospital of Laredo
Laredo, Texas, 78041, United States
Texas Tech University Health Sciences Center
Lubbock, Texas, 79430, United States
American Fork Hospital
American Fork, Utah, 84003, United States
Logan Regional Hospital
Logan, Utah, 84321, United States
Cottonwood Hospital Medical Center
Murray, Utah, 84107, United States
McKay-Dee Hospital Center
Ogden, Utah, 84403, United States
Utah Valley Regional Medical Center
Provo, Utah, 84604-3337, United States
Intermountain Health Care
Salt Lake City, Utah, 84103, United States
Utah Cancer Specialists-Salt Lake City
Salt Lake City, Utah, 84106, United States
LDS Hospital
Salt Lake City, Utah, 84143, United States
Dixie Medical Center Regional Cancer Center
St. George, Utah, 84770, United States
Fletcher Allen Health Care-Medical Center
Burlington, Vermont, 05401, United States
Northern Virginia Pelvic Surgery Associates
Annandale, Virginia, 22003, United States
University of Virginia
Charlottesville, Virginia, 22908, United States
Bon Secours Mary Immaculate Hospital
Newport News, Virginia, 23602, United States
Southwest VA Regional Cancer Center
Norton, Virginia, 24273, United States
Virginia Commonwealth University
Richmond, Virginia, 23298, United States
Carilion Clinic Gynecological Oncology
Roanoke, Virginia, 24016, United States
Good Samaritan Community Hospital
Puyallup, Washington, 98372, United States
University of Washington Medical Center
Seattle, Washington, 98195, United States
Northwest CCOP
Tacoma, Washington, 98405, United States
Northwest Medical Specialties PLLC
Tacoma, Washington, 98405, United States
Saint Joseph Medical Center
Tacoma, Washington, 98405, United States
Tacoma General Hospital
Tacoma, Washington, 98405, United States
Multicare Health System
Tacoma, Washington, 98415, United States
Wheeling Hospital
Wheeling, West Virginia, 26003, United States
Green Bay Oncology at Saint Vincent Hospital
Green Bay, Wisconsin, 54301-3526, United States
Saint Vincent Hospital
Green Bay, Wisconsin, 54301, United States
Green Bay Oncology Limited at Saint Mary's Hospital
Green Bay, Wisconsin, 54303, United States
Saint Mary's Hospital
Green Bay, Wisconsin, 54303, United States
Bay Area Medical Center
Marinette, Wisconsin, 54143, United States
Froedtert and the Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
Green Bay Oncology - Oconto Falls
Oconto Falls, Wisconsin, 54154, United States
Green Bay Oncology - Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235, United States
Aurora West Allis Medical Center
West Allis, Wisconsin, 53227, United States
Tom Baker Cancer Centre
Calgary, Alberta, T2N 4N2, Canada
BCCA-Fraser Valley Cancer Centre
Surrey, British Columbia, V3V 1Z2, Canada
BCCA-Vancouver Cancer Centre
Vancouver, British Columbia, V5Z 4E6, Canada
Health Sciences North
Greater Sudbury, Ontario, P3E 5J1, Canada
Thunder Bay Regional Health Science Centre
Thunder Bay, Ontario, P7B 6V4, Canada
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N 3M5, Canada
CHUM - Hopital Notre-Dame
Montreal, Quebec, H2L 4M1, Canada
CHUQ - Pavilion Hotel-Dieu de Quebec
Québec, Quebec, G1R 2J6, Canada
Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1, Canada
Related Publications (1)
DiSilvestro PA, Ali S, Craighead PS, Lucci JA, Lee YC, Cohn DE, Spirtos NM, Tewari KS, Muller C, Gajewski WH, Steinhoff MM, Monk BJ. Phase III randomized trial of weekly cisplatin and irradiation versus cisplatin and tirapazamine and irradiation in stages IB2, IIA, IIB, IIIB, and IVA cervical carcinoma limited to the pelvis: a Gynecologic Oncology Group study. J Clin Oncol. 2014 Feb 10;32(5):458-64. doi: 10.1200/JCO.2013.51.4265. Epub 2014 Jan 6.
PMID: 24395863DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Limitations and Caveats
Premature closure due to lack of study drug leading to small number of subjects analyzed.
Results Point of Contact
- Title
- Angela M. Kuras, Associate Director of Data Management
- Organization
- NRG Oncology Statistics and Data Management Center - Buffalo
Study Officials
- PRINCIPAL INVESTIGATOR
Paul DiSilvestro
Gynecologic Oncology Group
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- LTE60
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- NIH
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 6, 2005
First Posted
December 7, 2005
Study Start
February 1, 2006
Primary Completion
August 1, 2010
Study Completion
August 1, 2010
Last Updated
July 23, 2019
Results First Posted
July 2, 2017
Record last verified: 2019-07