Depression and Transcranial Direct Current Stimulation (tDCS)
The Treatment of Depression Using Transcranial Direct Current Stimulation (tDCS): a Pilot Study.
1 other identifier
interventional
20
1 country
1
Brief Summary
Transcranial direct current stimulation (tDCS)is a non invasive technique which uses a very weak current to change excitability in targeted regions of the brain. Early studies suggest that it has antidepressant properties. This study will test the safety and efficacy of tDCS as a treatment for depression.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_1 depression
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 17, 2005
CompletedFirst Posted
Study publicly available on registry
November 21, 2005
CompletedStudy Start
First participant enrolled
February 1, 2006
CompletedJuly 10, 2006
July 1, 2006
November 17, 2005
July 6, 2006
Conditions
Keywords
Outcome Measures
Primary Outcomes (6)
All measures at baseline and after each 5 treatments:
Montgomery& Asberg Depression Rating Scale
Hamilton Psychiatric Rating Scale for Depression
Clinical Global Impression-Severity
Beck Depression Inventory
Patient Global Impression-Severity
Secondary Outcomes (5)
Neuropsychological assessment at baseline and after each 5 treatments:
Rey Auditory Verbal Learning Task
Digit span
Trail Making Test
Controlled Oral Word Association
Interventions
Eligibility Criteria
You may qualify if:
- DSM-IV Major Depressive Episode of less than or equal to 3 years
- Montgomery-Asberg Depression Rating Scale score of 25 or more
- Aged 18-65
- May or may not be taking antidepressant medication
You may not qualify if:
- Not able to give written informed consent
- Failure to respond to ECT in current or past episodes of depression
- On antipsychotic, anticonvulsant or benzodiazepine medication which cannot be withdrawn.
- Significant other Axis I psychiatric disorder e.g schizophrenia, bipolar
- In imminent physical or psychological danger and needs a rapid clinical response due to inanition, psychosis or high suicidality
- Drug or alcohol dependence or abuse currently or in the last 12 months
- History of neurological illness e.g epilepsy; neurosurgical procedure
- Metal in the cranium, pacemaker, cochlear implant, medication or other electronic device in the body
- Woman of child-bearing age in whom pregnancy cannot be ruled out by B HCG
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Black Dog Institute Building, School of Psychiatry, University of NSW
Sydney, New South Wales, 2031, Australia
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Perminder P Sachdev, FRANZCP PhD
University of NSW
- PRINCIPAL INVESTIGATOR
Colleen K Loo, FRANZCP, MD
University of NSW
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
November 17, 2005
First Posted
November 21, 2005
Study Start
February 1, 2006
Last Updated
July 10, 2006
Record last verified: 2006-07