Brain Glucose Metabolism During Transcranial Direct Current Stimulation

NCT02999607 | Completed

• 1 other identifier: 3.0.30.11.16
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

With this study we will be able to dose-dependently measure real-time glucose metabolism changes after non-invasively stimulating superficial parts of the dlPFC, a commonly used target in therapeutic tDCS applications. This will provide further insight if and how tDCS is capable to change one of most reliable parameters of brain metabolism.

Conditions

Depression

Keywords

Transcranial direct current stimulation; Positron emission tomography

Outcome Measures

Primary Outcomes (1)

• FDG-rCMRglu

  regional cerebral metabolic rate of glucose

  70 minutes

Study Arms (2)

active transcranial direct current stimulation

EXPERIMENTAL

Stimulation at three different intensities during FDG-PET scan

Other: transcranial direct current stimulation

Sham tDCS

SHAM COMPARATOR

Comparator to active arm

Other: transcranial direct current stimulation

Interventions

transcranial direct current stimulation OTHER

0.5 mA, 1mA, 2mA for 10 minutes each

Sham tDCS; active transcranial direct current stimulation

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy controls:
• \- Aged 18 to 55 years Somatic and psychiatric health based on medical history, physical examination, ECG, laboratory screening, SCID-I and II Willingness and competence to complete the informed consent process
• Depressed Patients:
• Current major depressive episode during unipolar major depression (MD) according to SCID-I (with HAMD\>17) No other concomitant axis-I disease apart from anxiety disorder, which must be secondary to MD Standard antidepressant medication stable during the last 4 weeks

You may not qualify if:

• Concomitant major medical or neurological illness, including history of seizures Any current substance abuse disorder according to DSM-V (urinary test and history) including current sedative usage in MDD patients ECT, TMS or NMDA-antagonists (ketamine) during the past 6 months. Current augmentation with anti-epileptics, or other drugs affecting seizure threshold Failure to comply with the study protocol or follow the instructions of the investigators Pregnancy Participants with previous total radiation exposure dose of 30mSv over the last 10 years (according to legislation on radiation protection).
• Left-handedness

Sponsors & Collaborators

• Medical University of Vienna: lead

Study Sites (1)

Department of Psychiatry and Psychotherapy, Medical University of Vienna

Vienna, 1090, Austria

Location

MeSH Terms

Conditions

Depression

Interventions

Transcranial Direct Current Stimulation

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof. Priv.-Doz.

Study Record Dates

• First Submitted: December 18, 2016
• First Posted: December 21, 2016
• Study Start: December 1, 2016
• Primary Completion: September 1, 2017
• Study Completion: September 1, 2017
• Last Updated: January 16, 2018

Record last verified: 2018-01

Locations

AU (1)