Morphofunctional Imaging and Developmental Dyslexia

NCT00254644 | Completed

• 1 other identifier: PHRR04-CH/DYS
• Study Type: observational
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

Developmental dyslexia is a frequent learning disability. The aim of this study is to analyze cortical thickness and phonological treatment in right handed adults with developmental dyslexia. They are compared to control adults paired with age and laterality. To study phonological treatment, the researchers used functional magnetic resonance imaging (fMRI) with a rime judgement task and silent word generation.

Conditions

Developmental Dyslexia

Keywords

phonological treatment; language; fMRI

Outcome Measures

Primary Outcomes (1)

• Cortical thickness

  The average cortical thickness maps of healthy subjects and dyslexic will be compared hemisphere by hemisphere. This will identify whether there are cortical areas including cortical thickness differed significantly between normal and dyslexic.ts of different ages

  2 years

Secondary Outcomes (1)

• Average cortical thickness

  2 years

Study Arms (2)

Dyslexia

adults from 18-35 ans.

Procedure: Morphological and functional MRI

Control

adults from 18-35 ans.

Procedure: Morphological and functional MRI

Interventions

Morphological and functional MRI PROCEDURE

one time

Control; Dyslexia

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

This is a prospective study including 15 right-handed male subjects, aged 18 to 35 years, carrying a developmental dyslexia and 15 control subjects handed the same sex. We chose to include only male subjects to obtain a homogeneous population and to avoid the problem of a functional organization differs according to gender.

You may qualify if:

• Developmental dyslexia according to Critchley.
• Normal performance intelligence quotient (PIQ)
• Age: 18-35 years
• Sex: Male
• Right handed
• No hearing deficit.

You may not qualify if:

• No head injury
• No attention deficit hyperactivity disorder (ADHD)

Sponsors & Collaborators

• University Hospital, Tours: lead

Study Sites (1)

CHU

Tours, 37044, France

Location

MeSH Terms

Conditions

Dyslexia; Language

Condition Hierarchy (Ancestors)

Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Specific Learning Disorder; Learning Disabilities; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurodevelopmental Disorders; Mental Disorders; Communication; Behavior

Study Officials

• Frédérique Bonnet-Brilhault

  CHU Tours

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 15, 2005
• First Posted: November 16, 2005
• Study Start: February 1, 2007
• Primary Completion: February 1, 2008
• Study Completion: February 1, 2008
• Last Updated: January 16, 2017

Record last verified: 2011-05

Locations

FR (1)