NCT00247091

Brief Summary

We conducted a longitudinal study to assess the immunogenicity of standard-titer measles vaccine in HIV-infected and uninfected Zambian children. The study hypothesis was that HIV-infected children would have higher rates of primary and secondary measles vaccine failure compared to uninfected children, contributing to decreased levels of population immunity to measles and facilitating measles virus transmission in regions of high HIV prevalence.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
700

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started May 2000

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2000

Completed
4.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2004

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

October 28, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

November 1, 2005

Completed
Last Updated

November 1, 2005

Status Verified

October 1, 2005

First QC Date

October 28, 2005

Last Update Submit

October 28, 2005

Conditions

HIV InfectionMeaslesChildren

Keywords

HIVmeaslesmeasles vaccinechildrenZambia

Interventions

standard-titer measles vaccineBIOLOGICAL

Eligibility Criteria

Age2 Months - 15 Months
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • children aged 2 to 8 months presenting for well-child care
  • reside within 10 miles of the study clinic
  • parents or caretakers provide signed informed consent

You may not qualify if:

  • children with severe illness

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Chawama Clinic

Lusaka, Zambia

Location

MeSH Terms

Conditions

HIV InfectionsMeasles

Condition Hierarchy (Ancestors)

Blood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralSexually Transmitted DiseasesLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System DiseasesMorbillivirus InfectionsParamyxoviridae InfectionsMononegavirales Infections

Study Officials

  • William J. Moss, MD

    Johns Hopkins University Bloomberg School of Public Health

    PRINCIPAL INVESTIGATOR

  • Felicity Cutts, MD

    London School of Hygiene and Tropical Medicine

    PRINCIPAL INVESTIGATOR

  • Francis Kasolo, MD, PhD

    University of Zambia

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
DEFINED POPULATION
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

October 28, 2005

First Posted

November 1, 2005

Study Start

May 1, 2000

Study Completion

September 1, 2004

Last Updated

November 1, 2005

Record last verified: 2005-10

Locations

ZA(1)