NCT00246987

Brief Summary

To determine the effect on glycemic control and lipid parameters of the 2.5 and 5 mg. doses of BMS-298585 in drug naive subjects with Type 2 diabetes as an adjunct to diet and exercise.

Trial Health

93
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
341

participants targeted

Target at P50-P75 for phase_3

Timeline
Completed

Started Jun 2003

Shorter than P25 for phase_3

Geographic Reach
7 countries

130 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2003

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2004

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

October 28, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

November 1, 2005

Completed
Last Updated

April 27, 2012

Status Verified

April 1, 2012

First QC Date

October 28, 2005

Last Update Submit

April 26, 2012

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in HbA1c from baseline to Week 24

Secondary Outcomes (1)

  • Changes achieved from baseline in FPG after 24 weeks. Changes achieved from baseline in 3 hour post-prandial AUC for glucose and insulin levels after 24 weeks vs. placebo.

Interventions

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Subjects with Type 2 diabetes
  • Drug Naive
  • HbA1c \>= 7.0% and \<= 10.0%
  • Body Mass Index \<= 41 kg/m2
  • Serum TG \<= 600 mg/dL

You may not qualify if:

  • Symptomatic Type 2 diabetes
  • History of bladder cancer
  • History of Myocardial Infarction (MI), coronary angioplasty or bypass grafts, valvular disease or repair, unstable angina pectoris, Transient Ischemic Attach (TIA), or Cerebrovascular Accident (CVA) within 6 months, congestive heart failure (NYHA Class II and IV), uncontrolled hypertension, history of renal disease, peripheral vascular disease (PVD), pulmonary disease, gastrointestinal disease, active liver disease or endocrine disease.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (130)

Local Institution

Anniston, Alabama, United States

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Birmingham, Alabama, United States

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Haleyville, Alabama, United States

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Hoover, Alabama, United States

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Fayetteville, Arizona, United States

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Hot Springs, Arizona, United States

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Mesa, Arizona, United States

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Phoenix, Arizona, United States

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Tucson, Arizona, United States

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Tulsa, Arizona, United States

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Concord, California, United States

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Fountain Valley, California, United States

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Long Beach, California, United States

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Los Gatos, California, United States

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Raleigh, California, United States

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Roseville, California, United States

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San Diego, California, United States

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Spring Valley, California, United States

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Tustin, California, United States

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Colorado Springs, Colorado, United States

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Golden, Colorado, United States

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Littleton, Colorado, United States

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New Britain, Connecticut, United States

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Altamonte Springs, Florida, United States

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Brandon, Florida, United States

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Chipley, Florida, United States

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Coral Gables, Florida, United States

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Kissimmee, Florida, United States

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Longwood, Florida, United States

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Melbourne, Florida, United States

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New Port Richie, Florida, United States

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Ocala, Florida, United States

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Pinellas Park, Florida, United States

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Chicago, Illinois, United States

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Overland Park, Kansas, United States

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Shawnee Mission, Kansas, United States

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Lexington, Kentucky, United States

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Madisonville, Kentucky, United States

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Shreveport, Louisiana, United States

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Gulfport, Mississippi, United States

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Saint Peters, Mississippi, United States

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Chesterfield, Missouri, United States

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Kansas City, Missouri, United States

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Springfield, Missouri, United States

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Elizabeth, New Jersey, United States

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Toms River, New Jersey, United States

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Endwell, New York, United States

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West Seneca, New York, United States

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Charlotte, North Carolina, United States

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High Point, North Carolina, United States

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Morehead City, North Carolina, United States

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Salisbury, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Franklin, Ohio, United States

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Newark, Ohio, United States

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Zanesville, Ohio, United States

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Eugene, Oregon, United States

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Portland, Oregon, United States

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Philadelphia, Pennsylvania, United States

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Reading, Pennsylvania, United States

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Warminster, Pennsylvania, United States

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East Providence, Rhode Island, United States

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Johnston, Rhode Island, United States

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Providence, Rhode Island, United States

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Anderson, South Carolina, United States

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Greer, South Carolina, United States

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Mt. Pleasant, South Carolina, United States

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Knoxville, Tennessee, United States

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Memphis, Tennessee, United States

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Fort Worth, Texas, United States

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Lubbock, Texas, United States

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San Angelo, Texas, United States

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San Antonio, Texas, United States

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Salt Lake City, Utah, United States

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Richmond, Virginia, United States

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Virginia Beach, Virginia, United States

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Edmonds, Washington, United States

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Federal Way, Washington, United States

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Olympia, Washington, United States

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Spokane, Washington, United States

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Vancouver, Washington, United States

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Milwaukee, Wisconsin, United States

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Canberra, New South Wales, Australia

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Sydney, New South Wales, Australia

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Wollongong, New South Wales, Australia

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Kippa-Ring, Queensland, Australia

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Meadowbrook, Queensland, Australia

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Adelaide, South Australia, Australia

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Woodville, South Australia, Australia

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Launceston, Tasmania, Australia

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Tasmania

Melbourne, Victoria, Australia

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Calgary, Alberta, Canada

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Edmonton, Alberta, Canada

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Coquitlam, British Columbia, Canada

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Winnipeg, Manitoba, Canada

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Manuels, Newfoundland and Labrador, Canada

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St. John's, Newfoundland and Labrador, Canada

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Halifax, Nova Scotia, Canada

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Markham, Ontario, Canada

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Oakville, Ontario, Canada

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Ottawa, Ontario, Canada

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Thornhill, Ontario, Canada

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Thunder Bay, Ontario, Canada

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Toronto, Ontario, Canada

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Charlottetown, Prince Edward Island, Canada

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Chicoutimi, Quebec, Canada

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Drummondville, Quebec, Canada

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Granby, Quebec, Canada

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Laval, Quebec, Canada

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Longueuil, Quebec, Canada

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Montreal, Quebec, Canada

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Pointe-Claire, Quebec, Canada

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Saint-Lambert, Quebec, Canada

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Ste-Foy, Quebec, Canada

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Regina, Saskatchewan, Canada

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Saskatoon, Saskatchewan, Canada

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Aguascalientes, Aguascalientes, Mexico

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Durango, Durango, Mexico

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Mexico City, Mexico City, Mexico

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Cuernavaca, Morelos, Mexico

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Krakow, Poland

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Lodz, Poland

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Mroków, Poland

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Warsaw, Poland

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Zabrze, Poland

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Añasco, Puerto Rico

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Ponce, Puerto Rico

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Rio Pieoras, Puerto Rico

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Changhua, Taiwan

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Taichung, Taiwan

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MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Interventions

muraglitazar

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

October 28, 2005

First Posted

November 1, 2005

Study Start

June 1, 2003

Study Completion

April 1, 2004

Last Updated

April 27, 2012

Record last verified: 2012-04

Locations