NCT00239772

Brief Summary

This study will evaluate the effectiveness of cognitive processing therapy versus prolonged exposure therapy in treating women with post-traumatic stress disorder (PTSD) brought on by sexual assault.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 1994

Completed
11.5 years until next milestone

First Submitted

Initial submission to the registry

October 13, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 17, 2005

Completed
Last Updated

June 5, 2014

Status Verified

June 1, 2014

First QC Date

October 13, 2005

Last Update Submit

June 4, 2014

Conditions

Post-Traumatic Stress Disorder

Keywords

Cognitive TherapyPTSDFemalesRapeTrauma

Outcome Measures

Primary Outcomes (1)

  • Post-traumatic stress disorder symptoms; measured immediately post-treatment and at 3, 6, and 9 months post-treatment

Secondary Outcomes (2)

  • Feelings of guilt and shame; measured immediately post-treatment and at 3, 6, and 9 months post-treatment

  • Overall perception of self and surroundings; measured immediately post-treatment and at 3, 6, and 9 months post-treatment

Interventions

Cognitive Processing TherapyBEHAVIORAL
Prolonged Exposure TherapyBEHAVIORAL

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • History of at least one incidence of rape
  • Diagnosed with post-traumatic stress disorder

You may not qualify if:

  • Rape occurred before the age of 13 and was committed by a family member
  • Rape was committed by a spouse who is currently living in the same household
  • Psychosis
  • Mental retardation
  • Current pathology that may complicate symptoms of post-traumatic stress disorder
  • Currently suicidal or parasuicidal
  • Currently addicted to drugs or alcohol
  • Illiterate

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Center for Trauma and Recovery, University of Missouri - St. Louis

St Louis, Missouri, 63121-4499, United States

Location

Related Publications (1)

  • Resick PA, Nishith P, Weaver TL, Astin MC, Feuer CA. A comparison of cognitive-processing therapy with prolonged exposure and a waiting condition for the treatment of chronic posttraumatic stress disorder in female rape victims. J Consult Clin Psychol. 2002 Aug;70(4):867-79. doi: 10.1037//0022-006x.70.4.867.

    PMID: 12182270RESULT

MeSH Terms

Conditions

Stress Disorders, Post-TraumaticWounds and Injuries

Condition Hierarchy (Ancestors)

Stress Disorders, TraumaticTrauma and Stressor Related DisordersMental Disorders

Study Officials

  • Patricia A. Resick, PhD

    National Center for PTSD, Women's Health Sciences Division

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

October 13, 2005

First Posted

October 17, 2005

Study Start

May 1, 1994

Last Updated

June 5, 2014

Record last verified: 2014-06

Locations

US(1)