Written Exposure Therapy for Posttraumatic Stress Disorder
WET
2 other identifiers
interventional
192
1 country
1
Brief Summary
Although evidence-based treatments for PTSD exist, a significant minority of individuals do not benefit from these treatments and many individuals to not seek treatment, citing barriers such as time commitment and expense of treatment. The goal of the proposed study is to establish an alternative PTSD treatment that is efficacious and efficient.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Mar 2013
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 15, 2013
CompletedFirst Posted
Study publicly available on registry
February 28, 2013
CompletedStudy Start
First participant enrolled
March 9, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 10, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
April 30, 2018
CompletedJanuary 15, 2019
January 1, 2019
4.8 years
February 15, 2013
January 14, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Clinician Administered PTSD Scale (CAPS)
Total score on the CAPS will be used to assess change in PTSD symptom severity from baseline (pre-treatment) until 36- weeks post first treatment session.
change from baseline PTSD symptom severity at 36 weeks post first treatment session
Secondary Outcomes (1)
treatment dropout
course of treatment
Study Arms (2)
Written Exposure Therapy
EXPERIMENTALWritten exposure treatment is a 5 session treatment in which participants write about their trauma event in a specified manner.
Cognitive Processing Therapy
ACTIVE COMPARATORcognitive processing therapy will be included as the evidence-based treatment for PTSD in this study.
Interventions
Written exposure therapy is a 5 session, weekly treatment in which individuals write about their trauma event in a specified manner.
Cognitive Processing Therapy (CPT) is an evidence-based treatment for PTSD. CPT consists of 12, weekly sessions.
Eligibility Criteria
You may qualify if:
- PTSD diagnosis
- if taking psychotropic medication, on stable dose for 2 months
- Ability to read and write in English
You may not qualify if:
- not currently engaged in active PTSD treatment
- no current diagnosis of substance dependence
- no current diagnosis of psychosis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Boston Universitylead
- National Institute of Mental Health (NIMH)collaborator
Study Sites (1)
National Center for PTSD at VA Boston Healthcare System
Boston, Massachusetts, 02130, United States
Related Publications (1)
Sloan DM, Marx BP, Lee DJ, Resick PA. A Brief Exposure-Based Treatment vs Cognitive Processing Therapy for Posttraumatic Stress Disorder: A Randomized Noninferiority Clinical Trial. JAMA Psychiatry. 2018 Mar 1;75(3):233-239. doi: 10.1001/jamapsychiatry.2017.4249.
PMID: 29344631RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Denise M. Sloan, Ph.D.
Boston University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 15, 2013
First Posted
February 28, 2013
Study Start
March 9, 2013
Primary Completion
January 10, 2018
Study Completion
April 30, 2018
Last Updated
January 15, 2019
Record last verified: 2019-01