NCT00232908

Brief Summary

This study will evaluate patient quality of life and tolerability of a HAART (highly active antiretroviral therapy) regimen containing twice-daily subcutaneous injections of Fuzeon in clinically stable, treatment-experienced patients with HIV-1 infection. All patients will use a 31-gauge thin-walled 8mm needle to administer Fuzeon. The anticipated time on study treatment is 3-12 months, and the target sample size is 100-500 individuals.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
361

participants targeted

Target at P75+ for phase_4 hiv-infections

Timeline
Completed

Started Jun 2004

Shorter than P25 for phase_4 hiv-infections

Geographic Reach
2 countries

106 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2004

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2005

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2005

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

October 4, 2005

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 5, 2005

Completed
Last Updated

November 2, 2016

Status Verified

November 1, 2016

Enrollment Period

1.3 years

First QC Date

October 4, 2005

Last Update Submit

November 1, 2016

Conditions

Outcome Measures

Primary Outcomes (1)

  • QoL (MOS-HIV)\n

    Baseline and Week 12

Secondary Outcomes (2)

  • Change from baseline in HIV-RNA

    Week 12

  • Change from baseline in CD4 count

    Week 12

Study Arms (1)

1

EXPERIMENTAL
Drug: ARV regimenDrug: enfuvirtide [Fuzeon]

Interventions

As prescribed

1

90mg sc bid for 12 weeks

1

Eligibility Criteria

Age16 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • adults or adolescents at least 16 years of age;
  • HIV-1 infection;
  • clinically stable, treatment-experienced;
  • evidence of HIV-1 replication despite ongoing antiretroviral therapy;
  • CD4 + count greater than 50 cells/mm3.

You may not qualify if:

  • previous use of Fuzeon and/or T-1249;
  • active, untreated opportunistic infection;
  • inability to self-inject, unless a reliable caregiver is available to inject.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (106)

Unknown Facility

Phoenix, Arizona, 85012, United States

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Bakersfield, California, 93301, United States

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Berkeley, California, 94705, United States

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Los Angeles, California, 90022, United States

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Los Angeles, California, 90026, United States

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Los Angeles, California, 90073, United States

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Modesto, California, 95350, United States

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Oakland, California, 94609, United States

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Palm Springs, California, 92262, United States

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Rancho Mirage, California, 92270, United States

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San Mateo, California, 94403, United States

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Tarzana, California, 91356, United States

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Washington D.C., District of Columbia, 20017, United States

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Bay Pines, Florida, 33744, United States

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Boynton Beach, Florida, 33426, United States

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Brandon, Florida, 33511, United States

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Daytona Beach, Florida, 32117, United States

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Fort Lauderdale, Florida, 33311, United States

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Fort Lauderdale, Florida, 33316, United States

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Fort Lauderdale, Florida, 33334, United States

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Fort Myers, Florida, 33901, United States

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Jacksonville, Florida, 32204, United States

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Jacksonville, Florida, 32206, United States

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Miami, Florida, 33137, United States

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Miami Beach, Florida, 33139, United States

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Miami Beach, Florida, 33140, United States

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North Palm Beach, Florida, 33408, United States

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Oakland Park, Florida, 33334, United States

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Orlando, Florida, 32806, United States

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Plantation, Florida, 33317, United States

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Pompano Beach, Florida, 33062, United States

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Port Saint Lucie, Florida, 34952, United States

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Sarasota, Florida, 34239, United States

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South Miami, Florida, 33143, United States

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Tallahassee, Florida, 32308, United States

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Tamarac, Florida, 33321, United States

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Tampa, Florida, 33607, United States

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Tampa, Florida, 33614, United States

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Vero Beach, Florida, 32960, United States

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Atlanta, Georgia, 30308, United States

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Atlanta, Georgia, 30309, United States

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Atlanta, Georgia, 30312, United States

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Atlanta, Georgia, 30318, United States

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Atlanta, Georgia, 30327, United States

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Atlanta, Georgia, 30342, United States

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Decatur, Georgia, 30033, United States

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Lawrenceville, Georgia, 30045, United States

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Boise, Idaho, 83704, United States

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Chicago, Illinois, 60612, United States

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Springfield, Illinois, 62703, United States

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Topeka, Kansas, 66606, United States

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Wichita, Kansas, 67214, United States

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Louisville, Kentucky, 40202, United States

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Silver Spring, Maryland, 20910, United States

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Berkley, Michigan, 48072-1550, United States

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Ypsilanti, Michigan, 48197, United States

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Minneapolis, Minnesota, 55404, United States

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Kansas City, Missouri, 64111, United States

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Kansas City, Missouri, 64112, United States

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St Louis, Missouri, 63108, United States

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St Louis, Missouri, 63117, United States

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St Louis, Missouri, 63139, United States

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Butte, Montana, 59701, United States

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Las Vegas, Nevada, 89102, United States

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East Orange, New Jersey, 07018, United States

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Englewood, New Jersey, 07631, United States

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Jersey City, New Jersey, 07302, United States

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Newark, New Jersey, 07102, United States

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Newark, New Jersey, 07103, United States

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Newark, New Jersey, 07112, United States

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Perth Amboy, New Jersey, 08861, United States

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Somers Point, New Jersey, 08244, United States

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West Orange, New Jersey, 07052, United States

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Manhasset, New York, 11030, United States

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Mount Vernon, New York, 10550, United States

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New York, New York, 10011, United States

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New York, New York, 10016, United States

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Rochester, New York, 14604, United States

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Staten Island, New York, 10304, United States

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Stony Brook, New York, 11794-8153, United States

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Winston-Salem, North Carolina, 27103, United States

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Akron, Ohio, 44304, United States

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Cincinnati, Ohio, 45206, United States

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Portland, Oregon, 97209-2534, United States

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Harrisburg, Pennsylvania, 17110, United States

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Philadelphia, Pennsylvania, 19107, United States

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Reading, Pennsylvania, 19601, United States

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West Reading, Pennsylvania, 19611, United States

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Charleston, South Carolina, 29425, United States

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Columbia, South Carolina, 29203, United States

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Austin, Texas, 78705, United States

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Dallas, Texas, 75219, United States

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Dallas, Texas, 75246, United States

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Fort Worth, Texas, 76104, United States

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Galveston, Texas, 77555, United States

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Houston, Texas, 77004, United States

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Houston, Texas, 77027, United States

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Houston, Texas, 77098, United States

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San Antonio, Texas, 78212, United States

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Fairfax, Virginia, 22030, United States

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Hampton, Virginia, 23666, United States

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Seattle, Washington, 98104, United States

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Seattle, Washington, 98109, United States

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Cagaus, 00725, Puerto Rico

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Ponce, 00717-1563, Puerto Rico

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San Juan, 00908, Puerto Rico

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MeSH Terms

Conditions

HIV Infections

Interventions

Enfuvirtide

Condition Hierarchy (Ancestors)

Blood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralSexually Transmitted DiseasesLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System Diseases

Intervention Hierarchy (Ancestors)

Peptide FragmentsPeptidesAmino Acids, Peptides, and ProteinsHIV Envelope Protein gp41Viral Fusion ProteinsMembrane Fusion ProteinsMembrane ProteinsProteinsHIV AntigensAntigens, ViralViral Proteinsenv Gene Products, Human Immunodeficiency VirusGene Products, envRetroviridae ProteinsHuman Immunodeficiency Virus ProteinsViral Envelope ProteinsViral Structural ProteinsAntigensBiological Factors

Study Officials

  • Clinical Trials

    Hoffmann-La Roche

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 4, 2005

First Posted

October 5, 2005

Study Start

June 1, 2004

Primary Completion

October 1, 2005

Study Completion

October 1, 2005

Last Updated

November 2, 2016

Record last verified: 2016-11

Locations