NCT00337701

Brief Summary

This study will evaluate the signs and symptoms associated with Fuzeon injection (90mg sc) using the B2000 needle-free injection device, in HIV-1 positive patients experienced to Fuzeon treatment, but having difficulty tolerating long-term (\>4 weeks) administration of Fuzeon with the standard needle and syringe. Patients will be randomized to the B2000 device or the standard needle and syringe for 4 weeks; all patients will use the B2000 device for the next 4 weeks. The anticipated time on study treatment is \<3 months, and the target sample size is 100-500 individuals.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
326

participants targeted

Target at P75+ for phase_4 hiv-infections

Timeline
Completed

Started Jun 2006

Shorter than P25 for phase_4 hiv-infections

Geographic Reach
2 countries

44 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2006

Completed
14 days until next milestone

First Submitted

Initial submission to the registry

June 15, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

June 16, 2006

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2007

Completed
Last Updated

November 3, 2015

Status Verified

November 1, 2015

Enrollment Period

7 months

First QC Date

June 15, 2006

Last Update Submit

November 2, 2015

Conditions

Outcome Measures

Primary Outcomes (1)

  • Composite endpoint (pain, induration, nodules/cysts)

    Throughout study

Secondary Outcomes (1)

  • AEs and ISRs

    Throughout study

Study Arms (2)

1

EXPERIMENTAL
Drug: enfuvirtide [Fuzeon]

2

EXPERIMENTAL
Drug: enfuvirtide [Fuzeon]

Interventions

90mg sc bid by Biojector 2000 NFID for 8 weeks

1

Eligibility Criteria

Age16 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • adult patients \>=16 years of age;
  • current or former Fuzeon user who may benefit from needle-free administration of Fuzeon;
  • naive to use of the B2000 device;
  • positive test results for human immunodeficiency virus infection.

You may not qualify if:

  • patients naive to Fuzeon;
  • inability to self-inject Fuzeon, or no reliable caregiver to administer injections;
  • evidence of active, untreated, opportunistic infections.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (44)

Unknown Facility

Birmingham, Alabama, 35294-2050, United States

Location

Unknown Facility

Phoenix, Arizona, 85006, United States

Location

Unknown Facility

Phoenix, Arizona, 85012, United States

Location

Unknown Facility

Fountain Valley, California, 92708, United States

Location

Unknown Facility

Hayward, California, 94545, United States

Location

Unknown Facility

Long Beach, California, 90813, United States

Location

Unknown Facility

Los Angeles, California, 90036, United States

Location

Unknown Facility

Palm Springs, California, 92262, United States

Location

Unknown Facility

San Francisco, California, 94115, United States

Location

Unknown Facility

Santa Clara, California, 95051, United States

Location

Unknown Facility

Denver, Colorado, 80220, United States

Location

Unknown Facility

Fort Lauderdale, Florida, 33316, United States

Location

Unknown Facility

Fort Myers, Florida, 33901, United States

Location

Unknown Facility

North Miami Beach, Florida, 33169, United States

Location

Unknown Facility

Orlando, Florida, 32803, United States

Location

Unknown Facility

Plantation, Florida, 33317, United States

Location

Unknown Facility

Port Saint Lucie, Florida, 34952, United States

Location

Unknown Facility

Tampa, Florida, 33614, United States

Location

Unknown Facility

Atlanta, Georgia, 30318, United States

Location

Unknown Facility

Decatur, Georgia, 30033, United States

Location

Unknown Facility

Boise, Idaho, 83704, United States

Location

Unknown Facility

Chicago, Illinois, 60657, United States

Location

Unknown Facility

Baltimore, Maryland, 21201, United States

Location

Unknown Facility

Silver Spring, Maryland, 20910, United States

Location

Unknown Facility

Boston, Massachusetts, 02215-3318, United States

Location

Unknown Facility

Berkley, Michigan, 48072-1550, United States

Location

Unknown Facility

St Louis, Missouri, 63117, United States

Location

Unknown Facility

St Louis, Missouri, 63139, United States

Location

Unknown Facility

Somers Point, New Jersey, 08244, United States

Location

Unknown Facility

Voorhees Township, New Jersey, 08043, United States

Location

Unknown Facility

New York, New York, 10011, United States

Location

Unknown Facility

New York, New York, 10016, United States

Location

Unknown Facility

Rochester, New York, 14604, United States

Location

Unknown Facility

Winston-Salem, North Carolina, 27103, United States

Location

Unknown Facility

Portland, Oregon, 97209-2534, United States

Location

Unknown Facility

Philadelphia, Pennsylvania, 19107, United States

Location

Unknown Facility

Fort Worth, Texas, 76104, United States

Location

Unknown Facility

Galveston, Texas, 77555, United States

Location

Unknown Facility

Houston, Texas, 77027, United States

Location

Unknown Facility

Houston, Texas, 77098, United States

Location

Unknown Facility

Hampton, Virginia, 23666, United States

Location

Unknown Facility

Spokane, Washington, 99204, United States

Location

Unknown Facility

Ponce, 00717-1563, Puerto Rico

Location

Unknown Facility

Santurce, 00909, Puerto Rico

Location

MeSH Terms

Conditions

HIV Infections

Interventions

Enfuvirtide

Condition Hierarchy (Ancestors)

Blood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralSexually Transmitted DiseasesLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System Diseases

Intervention Hierarchy (Ancestors)

Peptide FragmentsPeptidesAmino Acids, Peptides, and ProteinsHIV Envelope Protein gp41Viral Fusion ProteinsMembrane Fusion ProteinsMembrane ProteinsProteinsHIV AntigensAntigens, ViralViral Proteinsenv Gene Products, Human Immunodeficiency VirusGene Products, envRetroviridae ProteinsHuman Immunodeficiency Virus ProteinsViral Envelope ProteinsViral Structural ProteinsAntigensBiological Factors

Study Officials

  • Clinical Trials

    Hoffmann-La Roche

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 15, 2006

First Posted

June 16, 2006

Study Start

June 1, 2006

Primary Completion

January 1, 2007

Study Completion

January 1, 2007

Last Updated

November 3, 2015

Record last verified: 2015-11

Locations