Diagnostic Innovations in Glaucoma Study

NCT00221897 | Recruiting

• 2 other identifiers: EY08208; EY11008, EY027510R01EY027510
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

The overarching goal of our research study is to evaluate changes in visual function and optic nerve topography (the structure of the back of the eye) in patients with glaucoma (increased susceptibility to pressure inside the eye that can cause loss of vision) or those with an increased risk of developing the disease. The purpose of this study is to determine the best methods for detecting the presence or progression (worsening over time) of glaucoma in patients with and without myopia and its effects on daily and visual function and quality of life. With several sources of NIH and foundation funding over the last twenty years we have designed a robust research protocol to address the most challenging aspects of glaucoma management. The most recent focus of this research is 1) to improve our ability to detect open angle glaucoma in individuals with myopia and in individuals of European and African descent, 2) to determine whether monitoring of the retinal vasculature with new optical imaging instruments can improve glaucoma management and elucidate the pathophysiology of the disease, and 3) to differentiate between age-related changes and glaucomatous progression. The grants supporting this project include 3 NIH funded studies, 1) the University of California, San Diego UCSD -based "Diagnostic Innovations in Glaucoma Study" (DIGS funded since 1995): 2) the "African Descent and Glaucoma Evaluation Study" (ADAGES funded since 2002), 3) the Brightfocus Foundation National Glaucoma Research Program and 4) the UCSD-based "Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography Angiography" (funded since 2018). The ADAGES is a multi-center study with data collection also conducted at 2 other academic sites, the University of Alabama at Birmingham, and Columbia University. Enrolled healthy participants, glaucoma suspects and glaucoma patients are generally asked to return for two or more visits a year for several years. We then analyze whether the glaucoma patients are progressing and what factors influence their glaucoma status compared to healthy subjects and individuals suspected of having glaucoma.

Conditions

Primary Open Angle Glaucoma; Myopia

Keywords

Primary open angle glaucoma; Glaucoma/pathology; Glaucoma/physiopathology; Nerve Fibers/pathology; Risk factors glaucoma

Study Arms (2)

Healthy individuals

healthy controls with or without myopia

Persons at risk for or with primary open angle glaucoma

with or without myopia with a diagnosis of glaucoma, glaucoma suspect and ocular hypertension

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults

You may qualify if:

• Subjects are healthy controls with or without myopia, and patients with or without myopia with a diagnosis of glaucoma, glaucoma suspect and ocular hypertension
• They will be considered if they are above 18 years old.
• There is no upper age limit
• Subject are not restricted by gender, race or ethnicity.

You may not qualify if:

• Participants with other ocular or systemic conditions and treatment, which may affect visual function, are excluded.

Sponsors & Collaborators

• University of California, San Diego: lead
• National Eye Institute (NEI): collaborator

Study Sites (1)

UCSD, Hamilton Glaucoma Center

La Jolla, California, 92093-0946, United States

RECRUITING

Related Publications (60)

• Sample PA, Weinreb RN, Boynton RM. Acquired dyschromatopsia in glaucoma. Surv Ophthalmol. 1986 Jul-Aug;31(1):54-64. doi: 10.1016/0039-6257(86)90051-2.

  PMID: 3529468 RESULT

• Weinreb R.N. and Greve E.L. (Eds.). (2004). Glaucoma diagnosis. Structure and function. The Hague, The Netherlands: Kugler Publications.

  RESULT

• Anderson DR. Standard perimetry. Ophthalmol Clin North Am. 2003 Jun;16(2):205-12, vi. doi: 10.1016/s0896-1549(03)00005-1.

  PMID: 12809158 RESULT

• Anderson AJ, Johnson CA. Frequency-doubling technology perimetry. Ophthalmol Clin North Am. 2003 Jun;16(2):213-25. doi: 10.1016/s0896-1549(03)00011-7.

  PMID: 12809159 RESULT

• Racette L, Sample PA. Short-wavelength automated perimetry. Ophthalmol Clin North Am. 2003 Jun;16(2):227-36, vi-vii. doi: 10.1016/s0896-1549(03)00010-5.

  PMID: 12809160 RESULT

• Zangwill LM, Abunto T, Bowd C, Angeles R, Schanzlin DJ, Weinreb RN. Scanning laser polarimetry retinal nerve fiber layer thickness measurements after LASIK. Ophthalmology. 2005 Feb;112(2):200-7. doi: 10.1016/j.ophtha.2004.08.019.

  PMID: 15691551 RESULT

• Medeiros FA, Zangwill LM, Bowd C, Vessani RM, Susanna R Jr, Weinreb RN. Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography. Am J Ophthalmol. 2005 Jan;139(1):44-55. doi: 10.1016/j.ajo.2004.08.069.

  PMID: 15652827 RESULT

• Zangwill LM, Chan K, Bowd C, Hao J, Lee TW, Weinreb RN, Sejnowski TJ, Goldbaum MH. Heidelberg retina tomograph measurements of the optic disc and parapapillary retina for detecting glaucoma analyzed by machine learning classifiers. Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3144-51. doi: 10.1167/iovs.04-0202.

  PMID: 15326133 RESULT

• Bowd C, Zangwill LM, Medeiros FA, Hao J, Chan K, Lee TW, Sejnowski TJ, Goldbaum MH, Sample PA, Crowston JG, Weinreb RN. Confocal scanning laser ophthalmoscopy classifiers and stereophotograph evaluation for prediction of visual field abnormalities in glaucoma-suspect eyes. Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2255-62. doi: 10.1167/iovs.03-1087.

  PMID: 15223803 RESULT

• Sample PA, Chan K, Boden C, Lee TW, Blumenthal EZ, Weinreb RN, Bernd A, Pascual J, Hao J, Sejnowski T, Goldbaum MH. Using unsupervised learning with variational bayesian mixture of factor analysis to identify patterns of glaucomatous visual field defects. Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2596-605. doi: 10.1167/iovs.03-0343.

  PMID: 15277482 RESULT

• Medeiros FA, Sample PA, Weinreb RN. Frequency doubling technology perimetry abnormalities as predictors of glaucomatous visual field loss. Am J Ophthalmol. 2004 May;137(5):863-71. doi: 10.1016/j.ajo.2003.12.009.

  PMID: 15126151 RESULT

• Medeiros FA, Zangwill LM, Bowd C, Weinreb RN. Comparison of the GDx VCC scanning laser polarimeter, HRT II confocal scanning laser ophthalmoscope, and stratus OCT optical coherence tomograph for the detection of glaucoma. Arch Ophthalmol. 2004 Jun;122(6):827-37. doi: 10.1001/archopht.122.6.827.

  PMID: 15197057 RESULT

• Mohammadi K, Bowd C, Weinreb RN, Medeiros FA, Sample PA, Zangwill LM. Retinal nerve fiber layer thickness measurements with scanning laser polarimetry predict glaucomatous visual field loss. Am J Ophthalmol. 2004 Oct;138(4):592-601. doi: 10.1016/j.ajo.2004.05.072.

  PMID: 15488786 RESULT

• Belghith A, Medeiros FA, Bowd C, Liebmann JM, Girkin CA, Weinreb RN, Zangwill LM. Structural Change Can Be Detected in Advanced-Glaucoma Eyes. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT511-8. doi: 10.1167/iovs.15-18929.

  PMID: 27454660 RESULT

• Diniz-Filho A, Abe RY, Zangwill LM, Gracitelli CP, Weinreb RN, Girkin CA, Liebmann JM, Medeiros FA. Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography. Ophthalmology. 2016 Oct;123(10):2058-65. doi: 10.1016/j.ophtha.2016.07.006. Epub 2016 Aug 20.

  PMID: 27554036 RESULT

• Gracitelli CP, Tatham AJ, Zangwill LM, Weinreb RN, Abe RY, Diniz-Filho A, Paranhos A Jr, Baig S, Medeiros FA. Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma. Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1738-46. doi: 10.1167/iovs.15-18079.

  PMID: 27064394 RESULT

• Hammel N, Belghith A, Bowd C, Medeiros FA, Sharpsten L, Mendoza N, Tatham AJ, Khachatryan N, Liebmann JM, Girkin CA, Weinreb RN, Zangwill LM. Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes. Ophthalmology. 2016 Apr;123(4):760-70. doi: 10.1016/j.ophtha.2015.11.018. Epub 2015 Dec 30.

  PMID: 26746597 RESULT

• Saunders LJ, Medeiros FA, Weinreb RN, Zangwill LM. What rates of glaucoma progression are clinically significant? Expert Rev Ophthalmol. 2016;11(3):227-234. doi: 10.1080/17469899.2016.1180246. Epub 2016 May 13.

  PMID: 29657575 RESULT

• Silverman AL, Hammel N, Khachatryan N, Sharpsten L, Medeiros FA, Girkin CA, Liebmann JM, Weinreb RN, Zangwill LM. Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes. Ophthalmology. 2016 Feb;123(2):408-414. doi: 10.1016/j.ophtha.2015.09.047. Epub 2015 Oct 31.

  PMID: 26526632 RESULT

• Skaat A, De Moraes CG, Bowd C, Sample PA, Girkin CA, Medeiros FA, Ritch R, Weinreb RN, Zangwill LM, Liebmann JM; Diagnostic Innovations in Glaucoma Study and African Descent and Glaucoma Evaluation Study Groups. African Descent and Glaucoma Evaluation Study (ADAGES): Racial Differences in Optic Disc Hemorrhage and Beta-Zone Parapapillary Atrophy. Ophthalmology. 2016 Jul;123(7):1476-83. doi: 10.1016/j.ophtha.2016.03.025. Epub 2016 Apr 23.

  PMID: 27117781 RESULT

• Suh MH, Zangwill LM, Manalastas PI, Belghith A, Yarmohammadi A, Medeiros FA, Diniz-Filho A, Saunders LJ, Weinreb RN. Deep Retinal Layer Microvasculature Dropout Detected by the Optical Coherence Tomography Angiography in Glaucoma. Ophthalmology. 2016 Dec;123(12):2509-2518. doi: 10.1016/j.ophtha.2016.09.002. Epub 2016 Oct 18.

  PMID: 27769587 RESULT

• Suh MH, Zangwill LM, Manalastas PI, Belghith A, Yarmohammadi A, Medeiros FA, Diniz-Filho A, Saunders LJ, Yousefi S, Weinreb RN. Optical Coherence Tomography Angiography Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects. Ophthalmology. 2016 Nov;123(11):2309-2317. doi: 10.1016/j.ophtha.2016.07.023. Epub 2016 Aug 31.

  PMID: 27592175 RESULT

• Yarmohammadi A, Zangwill LM, Diniz-Filho A, Suh MH, Manalastas PI, Fatehee N, Yousefi S, Belghith A, Saunders LJ, Medeiros FA, Huang D, Weinreb RN. Optical Coherence Tomography Angiography Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT451-9. doi: 10.1167/iovs.15-18944.

  PMID: 27409505 RESULT

• Yarmohammadi A, Zangwill LM, Diniz-Filho A, Suh MH, Yousefi S, Saunders LJ, Belghith A, Manalastas PI, Medeiros FA, Weinreb RN. Relationship between Optical Coherence Tomography Angiography Vessel Density and Severity of Visual Field Loss in Glaucoma. Ophthalmology. 2016 Dec;123(12):2498-2508. doi: 10.1016/j.ophtha.2016.08.041. Epub 2016 Oct 7.

  PMID: 27726964 RESULT

• Yousefi S, Balasubramanian M, Goldbaum MH, Medeiros FA, Zangwill LM, Weinreb RN, Liebmann JM, Girkin CA, Bowd C. Unsupervised Gaussian Mixture-Model With Expectation Maximization for Detecting Glaucomatous Progression in Standard Automated Perimetry Visual Fields. Transl Vis Sci Technol. 2016 May 3;5(3):2. doi: 10.1167/tvst.5.3.2. eCollection 2016 May.

  PMID: 27152250 RESULT

• Zhang C, Tatham AJ, Abe RY, Diniz-Filho A, Zangwill LM, Weinreb RN, Medeiros FA. Corneal Hysteresis and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma. Am J Ophthalmol. 2016 Jun;166:29-36. doi: 10.1016/j.ajo.2016.02.034. Epub 2016 Mar 3.

  PMID: 26949135 RESULT

• Zhang C, Tatham AJ, Abe RY, Hammel N, Belghith A, Weinreb RN, Medeiros FA, Liebmann JM, Girkin CA, Zangwill LM. Macular Ganglion Cell Inner Plexiform Layer Thickness in Glaucomatous Eyes with Localized Retinal Nerve Fiber Layer Defects. PLoS One. 2016 Aug 18;11(8):e0160549. doi: 10.1371/journal.pone.0160549. eCollection 2016.

  PMID: 27537107 RESULT

• Akagi T, Zangwill LM, Saunders LJ, Yarmohammadi A, Manalastas PIC, Suh MH, Girkin CA, Liebmann JM, Weinreb RN. Rates of Local Retinal Nerve Fiber Layer Thinning before and after Disc Hemorrhage in Glaucoma. Ophthalmology. 2017 Sep;124(9):1403-1411. doi: 10.1016/j.ophtha.2017.03.059. Epub 2017 May 9.

  PMID: 28499748 RESULT

• Bowd C, Zangwill LM, Weinreb RN, Medeiros FA, Belghith A. Estimating Optical Coherence Tomography Structural Measurement Floors to Improve Detection of Progression in Advanced Glaucoma. Am J Ophthalmol. 2017 Mar;175:37-44. doi: 10.1016/j.ajo.2016.11.010. Epub 2016 Nov 30.

  PMID: 27914978 RESULT

• De Moraes CG, Hood DC, Thenappan A, Girkin CA, Medeiros FA, Weinreb RN, Zangwill LM, Liebmann JM. 24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma. Ophthalmology. 2017 Oct;124(10):1449-1456. doi: 10.1016/j.ophtha.2017.04.021. Epub 2017 May 24.

  PMID: 28551166 RESULT

• De Moraes CG, Murphy JT, Kaplan CM, Reimann JJ, Skaat A, Blumberg DM, Al-Aswad L, Cioffi GA, Girkin CA, Medeiros FA, Weinreb RN, Zangwill L, Liebmann JM. beta-Zone Parapapillary Atrophy and Rates of Glaucomatous Visual Field Progression: African Descent and Glaucoma Evaluation Study. JAMA Ophthalmol. 2017 Jun 1;135(6):617-623. doi: 10.1001/jamaophthalmol.2017.1082.

  PMID: 28494060 RESULT

• Hammel N, Belghith A, Weinreb RN, Medeiros FA, Mendoza N, Zangwill LM. Comparing the Rates of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Loss in Healthy Eyes and in Glaucoma Eyes. Am J Ophthalmol. 2017 Jun;178:38-50. doi: 10.1016/j.ajo.2017.03.008. Epub 2017 Mar 16.

  PMID: 28315655 RESULT

• Kabbara SW, Zangwill LM, Mundae R, Hammel N, Bowd C, Medeiros FA, Weinreb RN, Belghith A. Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch's membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis. Br J Ophthalmol. 2018 Mar;102(3):344-351. doi: 10.1136/bjophthalmol-2016-310111. Epub 2017 Aug 3.

  PMID: 28774935 RESULT

• Shoji T, Zangwill LM, Akagi T, Saunders LJ, Yarmohammadi A, Manalastas PIC, Penteado RC, Weinreb RN. Progressive Macula Vessel Density Loss in Primary Open-Angle Glaucoma: A Longitudinal Study. Am J Ophthalmol. 2017 Oct;182:107-117. doi: 10.1016/j.ajo.2017.07.011. Epub 2017 Jul 20.

  PMID: 28734815 RESULT

• Wu Z, Saunders LJ, Zangwill LM, Daga FB, Crowston JG, Medeiros FA. Impact of Normal Aging and Progression Definitions on the Specificity of Detecting Retinal Nerve Fiber Layer Thinning. Am J Ophthalmol. 2017 Sep;181:106-113. doi: 10.1016/j.ajo.2017.06.017. Epub 2017 Jun 29.

  PMID: 28669780 RESULT

• Yarmohammadi A, Zangwill LM, Diniz-Filho A, Saunders LJ, Suh MH, Wu Z, Manalastas PIC, Akagi T, Medeiros FA, Weinreb RN. Peripapillary and Macular Vessel Density in Patients with Glaucoma and Single-Hemifield Visual Field Defect. Ophthalmology. 2017 May;124(5):709-719. doi: 10.1016/j.ophtha.2017.01.004. Epub 2017 Feb 10.

  PMID: 28196732 RESULT

• Yarmohammadi A, Zangwill LM, Weinreb RN. Reply. Ophthalmology. 2017 May;124(5):e51. doi: 10.1016/j.ophtha.2016.11.031. No abstract available.

  PMID: 28433140 RESULT

• Mahmoudinezhad G, Moghimi S, Latif K, Brye N, Walker E, Nishida T, Du KH, Gunasegaran G, Wu JH, Liebmann JM, Fazio MA, Girkin CA, Zangwill LM, Weinreb RN. Number of macula optical coherence tomography scans needed to detect glaucoma progression. Br J Ophthalmol. 2025 May 30;109(6):675-681. doi: 10.1136/bjo-2023-324916.

  PMID: 39663002 DERIVED

• Mohammadzadeh V, Liang Y, Moghimi S, Xie P, Nishida T, Mahmoudinezhad G, Eslani M, Walker E, Kamalipour A, Micheletti E, Wu JH, Christopher M, Zangwill LM, Javidi T, Weinreb RN. Detection of glaucoma progression on longitudinal series of en-face macular optical coherence tomography angiography images with a deep learning model. Br J Ophthalmol. 2024 Nov 22;108(12):1688-1693. doi: 10.1136/bjo-2023-324528.

  PMID: 39117359 DERIVED

• Nishida T, Moghimi S, Gunasegaran G, Walker E, Wu JH, Rahmatnejad K, Zangwill LM, Baxter SL, Weinreb RN. Association between metformin use with circumpapillary retinal nerve fibre layer thickness and capillary vessel density in glaucoma. Br J Ophthalmol. 2024 Dec 17;109(1):45-51. doi: 10.1136/bjo-2023-325035.

  PMID: 38839252 DERIVED

• Nishida T, Micheletti E, Latif K, Du KH, Weinreb RN, Moghimi S. Impact of smoking on choroidal microvasculature dropout in glaucoma: a cross-sectional study. BMJ Open Ophthalmol. 2023 Oct;8(1):e001421. doi: 10.1136/bmjophth-2023-001421.

  PMID: 37899137 DERIVED

• Mahmoudinezhad G, Nishida T, Weinreb RN, Baxter SL, Chang AC, Nikkhoy N, Walker E, Liebmann JM, Girkin CA, Moghimi S. Associations of smoking and alcohol consumption with the development of open angle glaucoma: a retrospective cohort study. BMJ Open. 2023 Oct 4;13(10):e072163. doi: 10.1136/bmjopen-2023-072163.

  PMID: 37793935 DERIVED

• Wu JH, Moghimi S, Nishida T, Walker E, Kamalipour A, Li E, Mahmoudinezhad G, Zangwill LM, Weinreb RN. Evaluation of the long-term variability of macular OCT/OCTA and visual field parameters. Br J Ophthalmol. 2024 Jan 29;108(2):211-216. doi: 10.1136/bjo-2022-322470.

  PMID: 36585126 DERIVED

• Mahmoudinezhad G, Moghimi S, Nishida T, Micheletti E, Du KH, Mohammadzadeh V, Wu JH, Kamalipour A, Weinreb RN. Intraocular pressure increases the rate of macular vessel density loss in glaucoma. Br J Ophthalmol. 2024 Jan 29;108(2):181-187. doi: 10.1136/bjo-2022-322261.

  PMID: 36535749 DERIVED

• Wu JH, Moghimi S, Nishida T, Mahmoudinezhad G, M Zangwill L, Weinreb RN. Association of macular vessel density and ganglion cell complex thickness with central visual field progression in glaucoma. Br J Ophthalmol. 2023 Nov 22;107(12):1828-1833. doi: 10.1136/bjo-2022-321870.

  PMID: 36150750 DERIVED

• Wu JH, Moghimi S, Nishida T, Mohammadzadeh V, Kamalipour A, Zangwill LM, Weinreb RN. Association of macular OCT and OCTA parameters with visual acuity in glaucoma. Br J Ophthalmol. 2023 Nov;107(11):1652-1657. doi: 10.1136/bjo-2022-321460. Epub 2022 Sep 9.

  PMID: 36126109 DERIVED

• Nishida T, Moghimi S, Hou H, Proudfoot JA, Chang AC, David RCC, Kamalipour A, El-Nimri N, Rezapour J, Bowd C, Zangwill LM, Weinreb RN. Long-term reproducibility of optical coherence tomography angiography in healthy and stable glaucomatous eyes. Br J Ophthalmol. 2023 May;107(5):657-662. doi: 10.1136/bjophthalmol-2021-320034. Epub 2021 Dec 21.

  PMID: 34933897 DERIVED

• Yang Z, Mansouri K, Moghimi S, Weinreb RN. Nocturnal Variability of Intraocular Pressure Monitored With Contact Lens Sensor Is Associated With Visual Field Loss in Glaucoma. J Glaucoma. 2021 Mar 1;30(3):e56-e60. doi: 10.1097/IJG.0000000000001727.

  PMID: 33137021 DERIVED

• Hu R, Marin-Franch I, Racette L. Prediction accuracy of a novel dynamic structure-function model for glaucoma progression. Invest Ophthalmol Vis Sci. 2014 Oct 30;55(12):8086-94. doi: 10.1167/iovs.14-14928.

  PMID: 25358735 DERIVED

• Balasubramanian M, Arias-Castro E, Medeiros FA, Kriegman DJ, Bowd C, Weinreb RN, Holst M, Sample PA, Zangwill LM. Detecting glaucoma progression from localized rates of retinal changes in parametric and nonparametric statistical framework with type I error control. Invest Ophthalmol Vis Sci. 2014 Mar 19;55(3):1684-95. doi: 10.1167/iovs.13-13246.

  PMID: 24519427 DERIVED

• Tatham AJ, Meira-Freitas D, Weinreb RN, Marvasti AH, Zangwill LM, Medeiros FA. Estimation of retinal ganglion cell loss in glaucomatous eyes with a relative afferent pupillary defect. Invest Ophthalmol Vis Sci. 2014 Jan 29;55(1):513-22. doi: 10.1167/iovs.13-12921.

  PMID: 24282221 DERIVED

• Lisboa R, Mansouri K, Zangwill LM, Weinreb RN, Medeiros FA. Likelihood ratios for glaucoma diagnosis using spectral-domain optical coherence tomography. Am J Ophthalmol. 2013 Nov;156(5):918-926.e2. doi: 10.1016/j.ajo.2013.06.017. Epub 2013 Aug 20.

  PMID: 23972303 DERIVED

• Tatham AJ, Weinreb RN, Zangwill LM, Liebmann JM, Girkin CA, Medeiros FA. Estimated retinal ganglion cell counts in glaucomatous eyes with localized retinal nerve fiber layer defects. Am J Ophthalmol. 2013 Sep;156(3):578-587.e1. doi: 10.1016/j.ajo.2013.04.015. Epub 2013 Jun 7.

  PMID: 23746612 DERIVED

• Tatham AJ, Weinreb RN, Zangwill LM, Liebmann JM, Girkin CA, Medeiros FA. The relationship between cup-to-disc ratio and estimated number of retinal ganglion cells. Invest Ophthalmol Vis Sci. 2013 May 7;54(5):3205-14. doi: 10.1167/iovs.12-11467.

  PMID: 23557744 DERIVED

• Lisboa R, Paranhos A Jr, Weinreb RN, Zangwill LM, Leite MT, Medeiros FA. Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma. Invest Ophthalmol Vis Sci. 2013 May 13;54(5):3417-25. doi: 10.1167/iovs.13-11676.

  PMID: 23532529 DERIVED

• Balasubramanian M, Kriegman DJ, Bowd C, Holst M, Weinreb RN, Sample PA, Zangwill LM. Localized glaucomatous change detection within the proper orthogonal decomposition framework. Invest Ophthalmol Vis Sci. 2012 Jun 14;53(7):3615-28. doi: 10.1167/iovs.11-8847.

  PMID: 22491406 DERIVED

• Bowd C, Lee I, Goldbaum MH, Balasubramanian M, Medeiros FA, Zangwill LM, Girkin CA, Liebmann JM, Weinreb RN. Predicting glaucomatous progression in glaucoma suspect eyes using relevance vector machine classifiers for combined structural and functional measurements. Invest Ophthalmol Vis Sci. 2012 Apr 30;53(4):2382-9. doi: 10.1167/iovs.11-7951.

  PMID: 22427577 DERIVED

• Medeiros FA, Zangwill LM, Mansouri K, Lisboa R, Tafreshi A, Weinreb RN. Incorporating risk factors to improve the assessment of rates of glaucomatous progression. Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2199-207. doi: 10.1167/iovs.11-8639.

  PMID: 22410555 DERIVED

• Mansouri K, Leite MT, Weinreb RN, Tafreshi A, Zangwill LM, Medeiros FA. Association between corneal biomechanical properties and glaucoma severity. Am J Ophthalmol. 2012 Mar;153(3):419-427.e1. doi: 10.1016/j.ajo.2011.08.022. Epub 2011 Oct 21.

  PMID: 22018707 DERIVED

• Medeiros FA, Leite MT, Zangwill LM, Weinreb RN. Combining structural and functional measurements to improve detection of glaucoma progression using Bayesian hierarchical models. Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5794-803. doi: 10.1167/iovs.10-7111.

  PMID: 21693614 DERIVED

Related Links

• Official website at UCSD

MeSH Terms

Conditions

Glaucoma, Open-Angle; Myopia; Glaucoma

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases; Refractive Errors

Study Officials

• Linda Zangwill, PhD

  University of California, San Diego

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Veronica Inpirom

CONTACT

858-822-4669; vrubio@health.ucsd.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 14, 2005
• First Posted: September 22, 2005
• Study Start: April 1, 1995
• Primary Completion (Estimated): July 1, 2030
• Study Completion (Estimated): July 1, 2030
• Last Updated: October 24, 2025

Record last verified: 2025-10

Locations

US (1)