How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?

NCT00626847 | Completed

• 1 other identifier: IRB#07-826
• Study Type: observational
• Target: 97
• Locations: 1 country
• Sites: 1

Brief Summary

Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases. So far, research has only been able to find the genes responsible for glaucoma in a small percentage of people who have glaucoma. The purpose of this project is to study the genes in patients with and without glaucoma to find additional genes that may be responsible for causing glaucoma.

Conditions

Primary Open Angle Glaucoma

Keywords

primary open angle glaucoma; Nuclear Genetics; Mitochondrial DNA; POAG

Outcome Measures

Primary Outcomes (1)

• The investigators will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma.

  one blood draw

Study Arms (2)

1

Primary Open Angle Glaucoma (POAG)

2

Controls (Normals, patients without glaucoma)

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

glaucoma clinic

You may qualify if:

• yrs
• Caucasian or African American
• Male or female with POAG, PACG, PXFG,
• Normal

You may not qualify if:

• Other ophthamic co-morbidities
• Other ethnic groups
• Unable to understand and give informed consent

Sponsors & Collaborators

• Wills Eye: lead
• Jefferson Medical College of Thomas Jefferson University: collaborator
• Thomas Jefferson University: collaborator

Study Sites (1)

Wills Eye Glaucoma Service

Philadelphia, Pennsylvania, 19107, United States

Location

Related Publications (2)

• Abu-Amero KK, Azad TA, Spaeth GL, Myers J, Katz LJ, Moster M, Bosley TM. Unaltered myocilin expression in the blood of primary open angle glaucoma patients. Mol Vis. 2012;18:1004-9. Epub 2012 Apr 21.

  PMID: 22550394 RESULT

• Abu-Amero KK, Azad TA, Spaeth GL, Myers J, Katz LJ, Moster M, Bosley TM. Absence of altered expression of optineurin in primary open angle glaucoma patients. Mol Vis. 2012;18:1421-7. Epub 2012 Jun 1.

  PMID: 22690120 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

whole blood

MeSH Terms

Conditions

Glaucoma, Open-Angle

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases

Study Officials

• George L Spaeth, MD

  Wills Eye Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director Glaucoma Research Center Wills Eye; Director Medical Research and Education Glaucoma Service Foundation Wills Eye; Esposito Research Professor, Thomas Jefferson University

Study Record Dates

• First Submitted: February 20, 2008
• First Posted: February 29, 2008
• Study Start: March 1, 2008
• Primary Completion: August 1, 2009
• Study Completion: August 1, 2009
• Last Updated: November 21, 2016

Record last verified: 2016-11

Data Sharing

• IPD Sharing: Will share

Locations

US (1)