NCT00213798

Brief Summary

The majority of lung cancer patients have a tumor-derived genetic alteration in circulating plasma DNA that could be exploited as a diagnostic tool. The aim of this study is to evaluate if plasma DNA can be used as a valuable non invasive test to monitor disease progression without assessing the tumor.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Dec 2003

Longer than P75 for not_applicable

Geographic Reach
1 country

4 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2003

Completed
1.8 years until next milestone

First Submitted

Initial submission to the registry

September 13, 2005

Completed
8 days until next milestone

First Posted

Study publicly available on registry

September 21, 2005

Completed
5.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2011

Completed
Last Updated

December 22, 2025

Status Verified

December 1, 2025

First QC Date

September 13, 2005

Last Update Submit

December 15, 2025

Conditions

Non-Small Cell Lung CarcinomaSmall Cell Lung Cancer

Keywords

Lung cancerplasma DNAallelotypingfollow-upProspective StudyNon-Small Cell Lung CancerSmall Cell Lung Cancer

Interventions

Biopsy samplesPROCEDURE

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Presence of lung tumor to use fiberoscopy or surgical intervention for diagnosis.
  • No lung instability.
  • Individuals give all informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Service de Pneumologie, Hôpital Lyautey

Strasbourg, 67000, France

Location

Service de Chirurgie Thoracique, Hôpital Civil

Strasbourg, 67091, France

Location

Service de Pneumologie, Hôpital Civil

Strasbourg, 67091, France

Location

Service de Pneumologie, Hôpital de Hautepierre

Strasbourg, 67098, France

Location

Related Publications (1)

  • Beau-Faller M, Gaub MP, Schneider A, Ducrocq X, Massard G, Gasser B, Chenard MP, Kessler R, Anker P, Stroun M, Weitzenblum E, Pauli G, Wihlm JM, Quoix E, Oudet P. Plasma DNA microsatellite panel as sensitive and tumor-specific marker in lung cancer patients. Int J Cancer. 2003 Jun 20;105(3):361-70. doi: 10.1002/ijc.11079.

    PMID: 12704670RESULT

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell LungSmall Cell Lung CarcinomaLung Neoplasms

Condition Hierarchy (Ancestors)

Carcinoma, BronchogenicBronchial NeoplasmsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract Diseases

Study Officials

  • Michèle BEAU-FALLER, MD

    Service de Pneumologie, Hôpital de Hautepierre

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
SCREENING
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 13, 2005

First Posted

September 21, 2005

Study Start

December 1, 2003

Study Completion

August 1, 2011

Last Updated

December 22, 2025

Record last verified: 2025-12

Locations

FR(4)