Network Osteoporosis Study

NCT00209469 | Unknown Phase 2

• 1 other identifier: GPRN1.OSTEO.PL.6.0
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 4

Brief Summary

This study is evaluating the use of the drug alendronate in preventing or reversing bone loss in children and adolescents receiving steroid medications.

Conditions

Osteopenia; Osteoporosis

Outcome Measures

Primary Outcomes (1)

• Mean change of individual AP spine BMD (gm/cm2) determined by dual energy X-ray absorptiometry (DXA) at 6, 12,18, 24 and 30 Months.

Interventions

alendronate sodium DRUG

Eligibility Criteria

• Age: 8 Years - 22 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Subjects must be diagnosed with either ulcerative colitis, Crohn's disease, systemic-onset juvenile rheumatoid arthritis, juvenile dermatomyositis, systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD) or vasculitis according to standard criteria where available, and according to treating physicians when not available.
• Subjects must have diminished AP lumbar spine (L1-L4) BMD by DXA (Hologic 4500) with a Z score ≤ -1.5 SD assessed within 8 weeks of the Baseline Visit.
• Subjects must have received daily, alternate day or weekly systemic glucocorticoid therapy for a minimum of six months total in their life-time.
• Subjects must be between the ages of 8 and 21 years, 11 months, at randomization. Although subjects younger than 8 years of age may be affected by osteoporosis, limited normative data prevents assignment of a BMD Z score for this group. Subjects through 21 years, 11 months will be included because many individuals with chronic disorders will have an immature skeleton, and even in healthy individuals there is significant accrual of bone mass into the 20's, making this a dynamic and critical time period for analysis.
• Females who have had at least one menstrual cycle must either be abstinent or must be using an effective method of birth control (e.g. intrauterine contraceptive device, oral contraceptive, diaphragm or condom with contraceptive jelly, cream, or foam). This will be documented at each visit. Additionally, they must test negative on a urine pregnancy test which will be administered at every visit. Subjects will be informed that because the drug remains in the body for many years, it is possible that a developing fetus could be harmed by the drug even if a woman stops taking the drug long before she becomes pregnant.

You may not qualify if:

• Current or recent (within 6 months) treatment with therapeutic doses of a bisphosphonate, calcitonin, human growth hormone, and heparin, all agents known to alter bone density
• A history of recent (within one year of screening) major upper gastrointestinal (GI) disease (above the jejunum), including, but not limited to, peptic ulcer, esophageal disease or active GI bleeding, or ever had surgery of the upper GI tract other than pyloroplasty. A history of abnormalities of the esophagus which delay esophageal emptying, such as stricture or achalasia
• Hyperthyroidism (suppressed thyroid stimulating hormone (TSH) and elevated free thyroxine (T4)), hyperparathyroidism (elevated parathyroid hormone (PTH)), malignancy, rickets, or osteomalacia (by history), all assessed within 8 weeks of the Baseline Visit.
• (OH) vitamin D below 20 g/L
• Planned or current pregnancy and/or breastfeeding
• Renal dysfunction defined as dependence on dialysis or a creatinine clearance \< 35 ml/min, assessed within 4 weeks of the Baseline Visit. Creatinine clearance = \[(height in cm x 0.55)/plasma creatinine\] for all females and for males \< 13 years old; \[(height in cm x 0.70)/plasma creatinine\] for males  13 years old.
• Hepatic insufficiency defined as SGPT or SGOT greater than twice normal for age, assessed within 4 weeks of the Baseline Visit.
• Uncorrected hypocalcemia (ionized calcium\>10% below age-adjusted range), assessed within 4 weeks of the Baseline Visit.
• Known or suspected hypersensitivity to bisphosphonates
• Inability to follow instructions for dosing, including being unable to swallow the study medication with plain water first thing in the morning, stand or sit upright without any other food or beverage for at least 30 minutes following dosing and until their next meal
• Weight greater than 136 kg (300 lb), as the DXA is not reliable for subjects of this size
• Weight less than 17 kg (37 lb), assessed within 8 weeks of the Baseline Visit.
• Permanent foreign body (prosthetic, surgical clips, permanent earring/umbilical ring) in region of interest, or soft tissue calcinosis overlying the region of interest
• Inability to undergo dual energy X-ray absorptiometry or CT scan
• Developmental or cognitive delay which may interfere with cooperation and/or compliance with the procedures

Sponsors & Collaborators

• Glaser Pediatric Research Network: lead
• Elizabeth Glaser Pediatric AIDS Foundation: collaborator

Study Sites (4)

University of California, Los Angeles

Los Angeles, California, 90095, United States

Location

University of California, San Francisco

San Francisco, California, 94143, United States

Location

Stanford University

Stanford, California, 94305, United States

Location

Children's Hospital, Boston

Boston, Massachusetts, 02115, United States

Location

MeSH Terms

Conditions

Bone Diseases, Metabolic; Osteoporosis

Interventions

Alendronate

Condition Hierarchy (Ancestors)

Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Diphosphonates; Organophosphonates; Organophosphorus Compounds; Organic Chemicals

Study Officials

• Emily von Scheven, MD

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NETWORK

Study Record Dates

• First Submitted: September 12, 2005
• First Posted: September 21, 2005
• Study Start: July 1, 2002
• Study Completion: February 1, 2007
• Last Updated: September 21, 2005

Record last verified: 2005-09

Locations

US (4)