Metabolic Syndrome and Insulin Resistance in Primary Aldosteronism

NCT00173082 | Unknown

• 1 other identifier: 9461700402
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Primary aldosteronism (PA) is occasionally associated with impaired glucose tolerance. Glucose intolerance, in general metabolic syndrome is caused by suppression of insulin release from the pancreas and suppression of insulin sensitivity of the target tissues. Several studies have suggested that impaired glucose tolerance in primary aldosteronism is due to an inability of the beta cells to release insulin by potassium depletion. It was suggested glucose intolerance in PA is caused by the suppression of insulin release related to hypopotassemia and compensatory increase of insulin sensitivity is observed in PA. The increased insulin secretory capacity associated with correction of negative potassium balance may account for the increase in plasma leptin after curing primary aldosteronism. The conclusion with respect to the possible causal relationship between diabetes mellitus (DM) and PA, however, can be obtained after the evaluation of the effect of surgical /pharmacological treatment of PA.

Conditions

Primary Aldosteronism

Keywords

primary aldosteronism; Insulin resistance; Metabolic syndrome; OGTT

Interventions

Glucose tolerance test PROCEDURE

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age more than 18 years old
• Aldosteronism patients

You may not qualify if:

• Patients with pregnancy

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan

RECRUITING

Related Publications (3)

• Corry DB, Tuck ML. The effect of aldosterone on glucose metabolism. Curr Hypertens Rep. 2003 Apr;5(2):106-9. doi: 10.1007/s11906-003-0065-2.

  PMID: 12642008 BACKGROUND

• Widimsky J Jr, Strauch B, Sindelka G, Skrha J. Can primary hyperaldosteronism be considered as a specific form of diabetes mellitus? Physiol Res. 2001;50(6):603-7.

  PMID: 11829322 BACKGROUND

• Kreze A Sr, Kreze-Spirova E, Mikulecky M. Diabetes mellitus in primary aldosteronism. Bratisl Lek Listy. 2000;101(4):187-90.

  PMID: 10914461 BACKGROUND

MeSH Terms

Conditions

Hyperaldosteronism; Insulin Resistance; Metabolic Syndrome

Interventions

Glucose Tolerance Test

Condition Hierarchy (Ancestors)

Adrenocortical Hyperfunction; Adrenal Gland Diseases; Endocrine System Diseases; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Blood Chemical Analysis; Clinical Chemistry Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Endocrine; Investigative Techniques

Study Officials

• Kwan-Dun Wu, MD, PhD

  National Taiwan University Hospital

  STUDY CHAIR

• Vin-cent Wu, MD

  National Taiwan University Hospital

  STUDY DIRECTOR

Central Study Contacts

Vin-cent Wu, MD

CONTACT

+886-2-23562082; kdw@ha.mc.ntu.edu.tw

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 12, 2005
• First Posted: September 15, 2005
• Study Start: June 1, 2005
• Study Completion: July 1, 2008
• Last Updated: November 29, 2007

Record last verified: 2007-11

Locations

TW (1)