Prevalence of Primary Aldosteronism in Young Adults With Acute Stroke

NCT04203420 | Completed

• 1 other identifier: PASTROKE
• Study Type: observational
• Target: 116
• Locations: 1 country
• Sites: 1

Brief Summary

The guideline requires clinical works to screen for primary aldosteronism(PA) in young adults with family history of stroke at early onset. But the prevalence of PA in young adults with stroke onset before 45 years old had never been investigated. The study aimed to discover the prevalence as well as the clinical characteristics between patients with PA and those without PA during stroke attack. In order to fulfill this objective, investigators intended to conduct a cross-sectional study by taking screening and confirmatory tests among young adults who once admitted due to early onset of acute stroke.

Conditions

Primary Aldosteronism

Outcome Measures

Primary Outcomes (1)

• prevalence of PA

  to find out the proportion of PA patients in young adults with early onset of acute stroke

  through study completion, an average of 2 years

Study Arms (2)

patients with PA

patients who finally been diagnosed with primary aldosteronism

Other: screening and confirmatory tests

patients without PA

patients who finally been diagnosed without primary aldosteronism

Other: screening and confirmatory tests

Interventions

screening and confirmatory tests OTHER

screening test is a blood test of the ratio of plasma aldosterone concentration(PAC) and direct renin concentration(DRC), confirmatory test is Captopril Challenge test

patients with PA; patients without PA

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

patients who were once admitted in the First affiliated hospital of CQMU during Jan.2006 to Feb.2019 with stroke onset less than two weeks. Age between 18 to 45y.

You may qualify if:

• \- patients who were once admitted in the First affiliated hospital of Chongqing Medical university(CQMU), with stroke onset less than two weeks

You may not qualify if:

• death, serious sequela with motor, comprehensive or linguistic dysfunction, patients unwilling to join in, etiology of trauma, infective or tumor disease, patients with impaired cardiac, renal or liver function during admission-

Sponsors & Collaborators

• Chongqing Medical University: lead

Study Sites (1)

The First Affilated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Location

MeSH Terms

Conditions

Hyperaldosteronism

Interventions

Mass Screening

Condition Hierarchy (Ancestors)

Adrenocortical Hyperfunction; Adrenal Gland Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques and Procedures; Diagnosis; Health Surveys; Surveys and Questionnaires; Data Collection; Epidemiologic Methods; Investigative Techniques; Diagnostic Services; Preventive Health Services; Health Services; Health Care Facilities Workforce and Services; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Public Health Practice

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Department of Endocrinology

Study Record Dates

• First Submitted: December 13, 2019
• First Posted: December 18, 2019
• Study Start: July 1, 2017
• Primary Completion: November 1, 2019
• Study Completion: December 13, 2019
• Last Updated: December 18, 2019

Record last verified: 2019-12

Locations

CN (1)