Computerized Cognitive Training in the Elderly

NCT00146263 | Withdrawn

• 1 other identifier: BMHC-4018CTIL
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Background: The aging of the population has lead to a significant increase in the number of older people suffering from cognitive impairment and dementia. The present lack of effective drug therapy for these conditions makes it imperative to investigate other potential therapeutic interventions. Cognitive training has been described as possibly useful in improving cognitive function in elderly subjects with mild impairment and early dementia. However, there have been few well-designed studies to date and the results are equivocal. Most studies have relied on the use of paper-based neuropsychological assessment instruments with limited accuracy and reproducibility. The investigators have developed a validated computerized neuropsychological assessment battery with increased test-retest reliability. The purpose of this study is to assess the efficacy of a computerized training program on cognitive function in older persons with normal cognition, mild cognitive impairment, and early dementia. Description: A randomized prospective AB/BA crossover study. Methods: Eligible males and females aged 60 years and older following initial computerized neuropsychological assessment will be randomized to receive either a 12-session computerized cognitive training program, or no treatment. Repeat neuropsychological assessment will be followed by a 4-week no treatment phase, reassessment and crossover phase.

Conditions

Dementia

Keywords

mild cognitive impairment; dementia; Alzheimer's Disease; cognitive training

Outcome Measures

Primary Outcomes (1)

• Computerized cognitive assessment using the Mindstreams battery

  Changes in cognitive function including memory, executive function, visual spatial and attention.

  12 weeks

Study Arms (2)

Savyon

ACTIVE COMPARATOR

Computerized cognitive training using the Savyon software

Behavioral: Savyon

Control

PLACEBO COMPARATOR

Usual activity

Behavioral: Control

Interventions

Savyon BEHAVIORAL

Computerized cognitive training

Savyon

Control BEHAVIORAL

Usual activity

Control

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age: above 60 years old

You may not qualify if:

• Visual impairment
• Educational inability to perform training

Sponsors & Collaborators

• Beersheva Mental Health Center: lead

Study Sites (1)

Beersheva Mental Health Center

Beersheva, Israel

Location

MeSH Terms

Conditions

Dementia; Cognitive Dysfunction; Alzheimer Disease

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Cognition Disorders; Tauopathies; Neurodegenerative Diseases

Study Officials

• Tzvi Dwolatzky, MD

  Ben-Gurion University of the Negev

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 4, 2005
• First Posted: September 7, 2005
• Study Start: September 1, 2005
• Primary Completion: December 1, 2007
• Study Completion: December 1, 2007
• Last Updated: February 27, 2020

Record last verified: 2020-02

Data Sharing

• IPD Sharing: Will not share

Locations

IL (1)