Effectiveness of the DASH Diet at Reducing High Blood Pressure
Cardiovascular and Renal Hemodynamics and the DASH Diet
2 other identifiers
interventional
44
0 countries
N/A
Brief Summary
The purpose of this study is to test the effects of the DASH diet in patients with isolated systolic hypertension.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable cardiovascular-diseases
Started Jan 2006
Longer than P75 for not_applicable cardiovascular-diseases
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 20, 2005
CompletedFirst Posted
Study publicly available on registry
July 22, 2005
CompletedStudy Start
First participant enrolled
January 1, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2014
CompletedJanuary 13, 2016
January 1, 2016
3.4 years
July 20, 2005
January 12, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
Changes in central aortic stiffness, diastolic relaxation, renal blood flow,and vascular response to Ang II
Measured at 4 weeks
Study Arms (2)
1
ACTIVE COMPARATORDietary Approaches to Stop Hypertension (DASH)
2
PLACEBO COMPARATORControl diet
Interventions
Eligibility Criteria
You may qualify if:
- Isolated systolic hypertension: systolic blood pressure (SBP) in the range of 140-179 mm Hg and diastolic blood pressure (DBP) less than 90 mm Hg
- Body mass index (BMI) less than 40
- Current use of fewer than two blood pressure medications (which will be withdrawn prior to study)
You may not qualify if:
- Major concomitant diseases that may include but are not limited to active pulmonary disease within the past 6 months
- History of cardiovascular disorders such as angina, heart attack, heart failure, or stent placement
- Active gastrointestinal disease, including prior gastrointestinal surgery
- Renal disease with serum creatinine greater than 1.5 mg/dl (men) or 1.4 mg/dl (women)
- Insulin-dependent diabetes mellitus
- Current pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Maris SA, Williams JS, Sun B, Brown S, Mitchell GF, Conlin PR. Interactions of the DASH Diet with the Renin-Angiotensin-Aldosterone System. Curr Dev Nutr. 2019 Jul 31;3(9):nzz091. doi: 10.1093/cdn/nzz091. eCollection 2019 Sep.
PMID: 31528838DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Paul R. Conlin, MD
Brigham and Women's Hospital
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
July 20, 2005
First Posted
July 22, 2005
Study Start
January 1, 2006
Primary Completion
June 1, 2009
Study Completion
October 1, 2014
Last Updated
January 13, 2016
Record last verified: 2016-01