NCT00241813

Brief Summary

This study will examine the effects of two behavioral stress reduction programs, mindfulness meditation (MM) and the lifeskills program (LP), and a health education control program (CTL) on blood pressure.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
283

participants targeted

Target at P50-P75 for not_applicable cardiovascular-diseases

Timeline
Completed

Started Jan 2005

Longer than P75 for not_applicable cardiovascular-diseases

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2005

Completed
10 months until next milestone

First Submitted

Initial submission to the registry

October 17, 2005

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 19, 2005

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2009

Completed
Last Updated

December 17, 2012

Status Verified

December 1, 2012

Enrollment Period

4.9 years

First QC Date

October 17, 2005

Last Update Submit

December 13, 2012

Conditions

Outcome Measures

Primary Outcomes (1)

  • Resting SBP and 24-hour ambulatory SBP

    Measured after 12-week intervention and at 12-week follow-up

Secondary Outcomes (6)

  • Overnight urine NE excretion

    Measured after 12-week intervention and at 12-week follow-up

  • Overnight sodium excretion

    Measured after 12-week intervention and at 12-week follow-up

  • SBP reactivity to behavioral stressors

    Measured after 12-week intervention and at 12-week follow-up

  • Self-reported hostility and anger

    Measured after 12-week intervention and at 12-week follow-up

  • Percent of endothelium-dependent arterial vasodilation to reactive hyperemia

    Measured after 12-week intervention and at 12-week follow-up

  • +1 more secondary outcomes

Study Arms (4)

Health Education Control Program (CTL)

ACTIVE COMPARATOR

Health Education Control Program (CTL)

Behavioral: Health Education Control Program (CTL)

Mindfulness Meditation

EXPERIMENTAL

Mindfulness Meditation (MM) Program

Behavioral: Mindfulness Meditation (MM) Program

Lifeskills

EXPERIMENTAL

Lifeskills Program (LP)

Behavioral: Lifeskills Program (LP)

MM plus LP

EXPERIMENTAL

Mindfulness Meditation (MM) Program plus Lifeskills Program (LP)

Behavioral: Mindfulness Meditation (MM) ProgramBehavioral: Lifeskills Program (LP)

Interventions

Participants will take part in a mindfulness meditation (MM) program.

MM plus LPMindfulness Meditation

Participants will take part in a health education control program (CTL)

Health Education Control Program (CTL)

Participants will take part in a lifeskills program (LP).

LifeskillsMM plus LP

Eligibility Criteria

Age14 Years - 17 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • In ninth grade
  • SBP ranging from greater than or equal to 50th percentile to less than or equal to 95th percentile on three occasions

You may not qualify if:

  • Clinical Hypertension

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

Location

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Interventions

Mindfulness

Condition Hierarchy (Ancestors)

Vascular Diseases

Intervention Hierarchy (Ancestors)

Cognitive Behavioral TherapyBehavior TherapyPsychotherapyBehavioral Disciplines and Activities

Study Officials

  • Frank A. Treiber, Ph.D.

    Medical University of South Carolina

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 17, 2005

First Posted

October 19, 2005

Study Start

January 1, 2005

Primary Completion

December 1, 2009

Study Completion

December 1, 2009

Last Updated

December 17, 2012

Record last verified: 2012-12

Locations