NCT00104039|Completed
Brain Changes in Children and Adolescents With Behavioral Problems
Investigating the Neuro-Cognitive Underpinnings of the Emotional Dysfunction Linked to Childhood Behavioral Disturbance
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Investigating the Neuro-Cognitive Underpinnings of the Emotional Dysfunction Linked to Childhood Behavioral Disturbance
Sponsor study identifier
Secondary identifiers
observational
318
1 country
1
Study Start
February 17, 2005
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
July 21, 2016
Date type not reportedThis date has not been verified as actual or estimated.
Purpose: This study will examine brain activity in children age 10-18 with disruptive behavior problems, including conduct disorder (CD), oppositional defiant disorder (ODD), and attention deficit hyperactivity disorder (ADHD), compared with children without behavioral problems. Our goal is to examine differences in how emotions, social situations, and problem-solving situations are processed in the brain across these groups of children.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 21, 2016
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 17, 2005
Date type not reportedThis date has not been verified as actual or estimated.
February 19, 2005
Actual (reported)February 21, 2005
Actual (reported)July 21, 2016
Date type not reportedThis date has not been verified as actual or estimated.
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Ambrogi Lorenzini CG, Baldi E, Bucherelli C, Sacchetti B, Tassoni G. Neural topography and chronology of memory consolidation: a review of functional inactivation findings. Neurobiol Learn Mem. 1999 Jan;71(1):1-18. doi: 10.1006/nlme.1998.3865.
Aron AR, Fletcher PC, Bullmore ET, Sahakian BJ, Robbins TW. Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans. Nat Neurosci. 2003 Feb;6(2):115-6. doi: 10.1038/nn1003. No abstract available.
James J Blair, Ph.D.
National Institute of Mental Health (NIMH)
318 participants (actual enrollment reported by the registry).
First Submitted
February 19, 2005
First Posted
February 21, 2005
Study Start
February 17, 2005
Date type not reportedThis date has not been verified as actual or estimated.
Psychosocial Treatment for Attention Deficit Hyperactivity Disorder in Adults
Contact the study team to confirm eligibility.
Babinski LM, Hartsough CS, Lambert NM. Childhood conduct problems, hyperactivity-impulsivity, and inattention as predictors of adult criminal activity. J Child Psychol Psychiatry. 1999 Mar;40(3):347-55.
Hwang S, Meffert H, Parsley I, Tyler PM, Erway AK, Botkin ML, Pope K, Blair RJR. Segregating sustained attention from response inhibition in ADHD: An fMRI study. Neuroimage Clin. 2019;21:101677. doi: 10.1016/j.nicl.2019.101677. Epub 2019 Jan 15.
Tyler PM, White SF, Thompson RW, Blair RJR. Applying a Cognitive Neuroscience Perspective to Disruptive Behavior Disorders: Implications for Schools. Dev Neuropsychol. 2019 Jan-Feb;44(1):17-42. doi: 10.1080/87565641.2017.1334782. Epub 2018 Feb 12.
White SF, Thornton LC, Leshin J, Clanton R, Sinclair S, Coker-Appiah D, Meffert H, Hwang S, Blair JR. Looming Threats and Animacy: Reduced Responsiveness in Youth with Disrupted Behavior Disorders. J Abnorm Child Psychol. 2018 May;46(4):741-754. doi: 10.1007/s10802-017-0335-0.
White SF, VanTieghem M, Brislin SJ, Sypher I, Sinclair S, Pine DS, Hwang S, Blair RJ. Neural Correlates of the Propensity for Retaliatory Behavior in Youths With Disruptive Behavior Disorders. Am J Psychiatry. 2016 Mar 1;173(3):282-90. doi: 10.1176/appi.ajp.2015.15020250. Epub 2015 Oct 6.
Study Completion
July 21, 2016
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
November 5, 2019
Record last verified: 2016-07-21
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