Psychiatric Problems in Children and Adolescents Infected With HIV at Birth
Psychiatric Co-Morbidity in Perinatally HIV-Infected Children and Adolescents
2 other identifiers
observational
800
2 countries
32
Brief Summary
The purpose of this study is to determine whether HIV and anti-HIV drugs cause mental health problems or make mental health problems worse in children and adolescents who were infected with HIV at birth.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2005
32 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 3, 2005
CompletedFirst Posted
Study publicly available on registry
January 4, 2005
CompletedStudy Start
First participant enrolled
April 1, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2006
CompletedJanuary 21, 2011
January 1, 2011
1.4 years
January 3, 2005
January 20, 2011
Conditions
Keywords
Study Arms (1)
1
All HIV infected and uninfected participants and their caregivers.
Interventions
Measures and questionnaires regarding mental health, pain, and adherence to treatment. No actual treatment or intervention is given as part of this study.
Eligibility Criteria
Children and their caregivers from specific clinics.
You may qualify if:
- Acquired HIV through mother-to-child transmission
- HIV uninfected
- Living with same parent or primary caregiver for at least 12 months prior to study screening
- Willing and able to provide consent or assent
You may not qualify if:
- Acquired HIV through adult high-risk behavior, blood transfusion, or abuse
- IQ of 69 or lower, for participants whose primary language is English. More information on this criterion can be found in the protocol.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- International Maternal Pediatric Adolescent AIDS Clinical Trials Grouplead
- National Institute of Allergy and Infectious Diseases (NIAID)collaborator
- National Institute of Mental Health (NIMH)collaborator
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)collaborator
Study Sites (32)
Long Beach Memorial (Pediatric)
Long Beach, California, 90801, United States
Los Angeles County Medical Center/USC
Los Angeles, California, 90033, United States
UCLA Medical Center (Pediatric)
Los Angeles, California, 90095-1752, United States
4601 UCSD Mother, Child & Adolescent HIV Program
San Diego, California, 92103, United States
UCSF, Moffitt Hospital (Pediatric)
San Francisco, California, 94143-0105, United States
Harbor-UCLA Medical Center
Torrance, California, 90509, United States
Childrens Hospital (U. Colorado, Denver)
Denver, Colorado, 80218-1088, United States
Yale University School of Medicine
New Haven, Connecticut, 06504, United States
Howard University Hospital
Washington D.C., District of Columbia, 20060, United States
North Broward Hospital District
Fort Lauderdale, Florida, 33316, United States
University of Florida - Health Science Center
Jacksonville, Florida, 32209, United States
University of Miami (Pediatric)
Miami, Florida, 33136, United States
University of South Florida
St. Petersburg, Florida, 33701, United States
Chicago Childrens Memorial Hospital (Pediatric)
Chicago, Illinois, 60614, United States
University of Maryland (Pediatric)
Baltimore, Maryland, 21201, United States
Childrens Hospital of Boston
Boston, Massachusetts, 02115, United States
University of Massachusetts Medical School
Worcester, Massachusetts, 01655-0001, United States
New York University School of Medicine
New York, New York, 10016, United States
Metropolitan Hospital Center
New York, New York, 10029, United States
Mt. Sinai Medical Center
New York, New York, 10029, United States
State University of New York at Stony Brook
Stony Brook, New York, 11794-8111, United States
SUNY Upstate Medical University
Syracuse, New York, 13210, United States
Bronx Lebanon Hospital Center
The Bronx, New York, 10457, United States
Jacobi Medical Center
The Bronx, New York, 10461, United States
Duke University (Pediatric)
Durham, North Carolina, 27710, United States
Childrens Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104-4318, United States
St. Christophers Hosp. for Children, Philadelphia
Philadelphia, Pennsylvania, 19134, United States
St. Jude Childrens Research Hospital, Memphis
Memphis, Tennessee, 38105-2794, United States
Children's Hospital and Regional Medical Center/Seattle
Seattle, Washington, 98105, United States
Northwest Family Ctr./Harborview Medical Center
Seattle, Washington, 98105, United States
University of Washington Medical Ctr.
Seattle, Washington, 98105, United States
San Juan City Hospital
San Juan, Puerto Rico
Related Publications (7)
Bachanas PJ, Kullgren KA, Schwartz KS, Lanier B, McDaniel JS, Smith J, Nesheim S. Predictors of psychological adjustment in school-age children infected with HIV. J Pediatr Psychol. 2001 Sep;26(6):343-52. doi: 10.1093/jpepsy/26.6.343.
PMID: 11490035BACKGROUNDDe Luca A, Ciancio BC, Larussa D, Murri R, Cingolani A, Rizzo MG, Giancola ML, Ammassari A, Ortona L. Correlates of independent HIV-1 replication in the CNS and of its control by antiretrovirals. Neurology. 2002 Aug 13;59(3):342-7. doi: 10.1212/wnl.59.3.342.
PMID: 12177366BACKGROUNDGaughan DM, Hughes MD, Oleske JM, Malee K, Gore CA, Nachman S; Pediatric AIDS Clinical Trials Group 219C Team. Psychiatric hospitalizations among children and youths with human immunodeficiency virus infection. Pediatrics. 2004 Jun;113(6):e544-51. doi: 10.1542/peds.113.6.e544.
PMID: 15173535BACKGROUNDLwin R, Melvin D. Paediatric HIV infection. J Child Psychol Psychiatry. 2001 May;42(4):427-38.
PMID: 11383959BACKGROUNDMellins CA, Smith R, O'Driscoll P, Magder LS, Brouwers P, Chase C, Blasini I, Hittleman J, Llorente A, Matzen E; NIH NIAID/NICHD/NIDA-Sponsored Women and Infant Transmission Study Group. High rates of behavioral problems in perinatally HIV-infected children are not linked to HIV disease. Pediatrics. 2003 Feb;111(2):384-93. doi: 10.1542/peds.111.2.384.
PMID: 12563068BACKGROUNDChernoff M, Nachman S, Williams P, Brouwers P, Heston J, Hodge J, Di Poalo V, Deygoo NS, Gadow KD; IMPAACT P1055 Study Team. Mental health treatment patterns in perinatally HIV-infected youth and controls. Pediatrics. 2009 Aug;124(2):627-36. doi: 10.1542/peds.2008-2441. Epub 2009 Jul 13.
PMID: 19596734RESULTNachman S, Chernoff M, Williams P, Hodge J, Heston J, Gadow KD. Human immunodeficiency virus disease severity, psychiatric symptoms, and functional outcomes in perinatally infected youth. Arch Pediatr Adolesc Med. 2012 Jun 1;166(6):528-35. doi: 10.1001/archpediatrics.2011.1785.
PMID: 22312169DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Sharon Nachman, MD
Department of Pediatrics, Stony Brook University
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- NETWORK
Study Record Dates
First Submitted
January 3, 2005
First Posted
January 4, 2005
Study Start
April 1, 2005
Primary Completion
September 1, 2006
Study Completion
September 1, 2006
Last Updated
January 21, 2011
Record last verified: 2011-01